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Fusion gene ID: 33305 |
FusionGeneSummary for SERPINB5_CDH19 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SERPINB5_CDH19 | Fusion gene ID: 33305 | Hgene | Tgene | Gene symbol | SERPINB5 | CDH19 | Gene ID | 5268 | 28513 |
Gene name | serpin family B member 5 | cadherin 19 | |
Synonyms | PI5|maspin | CDH7|CDH7L2 | |
Cytomap | 18q21.33 | 18q22.1 | |
Type of gene | protein-coding | protein-coding | |
Description | serpin B5PI-5peptidase inhibitor 5protease inhibitor 5 (maspin)serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 5serpin peptidase inhibitor, clade B (ovalbumin), member 5 | cadherin-19cadherin 19, type 2 | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | P36952 | Q9H159 | |
Ensembl transtripts involved in fusion gene | ENST00000382771, ENST00000489441, ENST00000464346, | ENST00000262150, ENST00000540086, | |
Fusion gene scores | * DoF score | 2 X 2 X 2=8 | 3 X 2 X 3=18 |
# samples | 2 | 3 | |
** MAII score | log2(2/8*10)=1.32192809488736 | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: SERPINB5 [Title/Abstract] AND CDH19 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation | Tumor suppressor gene involved fusion gene, in-frame but not retained their domain. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | LUAD | TCGA-49-4490-01A | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
In-frame | ENST00000382771 | ENST00000262150 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
5CDS-intron | ENST00000382771 | ENST00000540086 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
In-frame | ENST00000489441 | ENST00000262150 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
5CDS-intron | ENST00000489441 | ENST00000540086 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
intron-3CDS | ENST00000464346 | ENST00000262150 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
intron-intron | ENST00000464346 | ENST00000540086 | SERPINB5 | chr18 | 61151829 | + | CDH19 | chr18 | 64178922 | - |
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FusionProtFeatures for SERPINB5_CDH19 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SERPINB5 | CDH19 |
Tumor suppressor. It blocks the growth, invasion, andmetastatic properties of mammary tumors. As it does not undergothe S (stressed) to R (relaxed) conformational transitioncharacteristic of active serpins, it exhibits no serine proteaseinhibitory activity. | Cadherins are calcium-dependent cell adhesion proteins.They preferentially interact with themselves in a homophilicmanner in connecting cells; cadherins may thus contribute to thesorting of heterogeneous cell types. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 149_256 | -83 | 491 | Domain | Cadherin 2 |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 257_370 | -83 | 491 | Domain | Cadherin 3 |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 371_470 | -83 | 491 | Domain | Cadherin 4 |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 44_148 | -83 | 491 | Domain | Cadherin 1 |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 470_581 | -83 | 491 | Domain | Cadherin 5 |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 618_772 | 486 | 773 | Topological domain | Cytoplasmic |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 44_596 | -83 | 491 | Topological domain | Extracellular |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 618_772 | -83 | 491 | Topological domain | Cytoplasmic |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 597_617 | 486 | 773 | Transmembrane | Helical |
Tgene | >CDH19 | chr18:61151829 | chr18:64178922 | ENST00000540086 | - | 0 | 10 | 597_617 | -83 | 491 | Transmembrane | Helical |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 149_256 | 486 | 773 | Domain | Cadherin 2 |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 257_370 | 486 | 773 | Domain | Cadherin 3 |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 371_470 | 486 | 773 | Domain | Cadherin 4 |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 44_148 | 486 | 773 | Domain | Cadherin 1 |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 470_581 | 486 | 773 | Domain | Cadherin 5 |
Tgene | CDH19 | chr18:61151829 | chr18:64178922 | ENST00000262150 | - | 8 | 12 | 44_596 | 486 | 773 | Topological domain | Extracellular |
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FusionGeneSequence for SERPINB5_CDH19 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
>In-frame_SERPINB5_ENST00000382771_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_343aa MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFT IIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFG FIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFIL >In-frame_SERPINB5_ENST00000489441_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_343aa MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQVGAKGDTANEIGQVIQTISAVDRDESIEEHHFYFNLSVEDTNNSSFT IIDNQDNTAVILTNRTGFNLQEEPVFYISILIADNGIPSLTSTNTLTIHVCDCGDSGSTQTCQYQELVLSMGFKTEVIIAILICIMIIFG FIFLTLGLKQRRKQILFPEKSEDFRENIFQYDDEGGGEEDTEAFDIAELRSSTIMRERKTRKTTSAEIRSLYRQSLQVGPDSAIFRKFIL |
* Fusion transcript sequences (only coding sequence (CDS) region). |
>In-frame_SERPINB5_ENST00000382771_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_1029nt ATGGATGCCCTGCAACTAGCAAATTCGGCTTTTGCCGTTGATCTGTTCAAACAACTATGTGAAAAGGAGCCACTGGGCAATGTCCTCTTC TCTCCAATCTGTCTCTCCACCTCTCTGTCACTTGCTCAAGTGGGTGCTAAAGGTGACACTGCAAATGAAATTGGACAGGTAATTCAGACT ATCAGTGCAGTGGATAGAGATGAATCCATAGAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGACACTAACAATTCAAGTTTTACA ATCATAGATAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTTCAAGAAGAACCTGTCTTCTACATCTCCATC TTAATTGCCGACAATGGAATCCCGTCACTTACAAGTACAAACACCCTTACCATCCATGTCTGTGACTGTGGTGACAGTGGGAGCACACAG ACCTGCCAGTACCAGGAGCTTGTGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCTATTCTCATTTGCATTATGATCATATTTGGG TTTATTTTTTTGACTTTGGGTTTAAAACAACGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGATTTCAGAGAGAATATATTCCAA TATGATGATGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGATATAGCAGAGCTGAGGAGTAGTACCATAATGCGGGAACGCAAGACT CGGAAAACCACAAGCGCTGAGATCAGGAGCCTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGCCATATTCAGGAAATTCATTCTG GAAAAGCTCGAAGAAGCTAATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACCTACGCTTTTGAGGGAACAGGGTCATTAGCT GGATCCCTGAGCTCCTTAGAATCAGCAGTCTCTGATCAGGATGAAAGCTATGATTACCTTAATGAGTTGGGACCTCGCTTTAAAAGATTA >In-frame_SERPINB5_ENST00000489441_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_1029nt ATGGATGCCCTGCAACTAGCAAATTCGGCTTTTGCCGTTGATCTGTTCAAACAACTATGTGAAAAGGAGCCACTGGGCAATGTCCTCTTC TCTCCAATCTGTCTCTCCACCTCTCTGTCACTTGCTCAAGTGGGTGCTAAAGGTGACACTGCAAATGAAATTGGACAGGTAATTCAGACT ATCAGTGCAGTGGATAGAGATGAATCCATAGAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGACACTAACAATTCAAGTTTTACA ATCATAGATAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTTCAAGAAGAACCTGTCTTCTACATCTCCATC TTAATTGCCGACAATGGAATCCCGTCACTTACAAGTACAAACACCCTTACCATCCATGTCTGTGACTGTGGTGACAGTGGGAGCACACAG ACCTGCCAGTACCAGGAGCTTGTGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCTATTCTCATTTGCATTATGATCATATTTGGG TTTATTTTTTTGACTTTGGGTTTAAAACAACGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGATTTCAGAGAGAATATATTCCAA TATGATGATGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGATATAGCAGAGCTGAGGAGTAGTACCATAATGCGGGAACGCAAGACT CGGAAAACCACAAGCGCTGAGATCAGGAGCCTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGCCATATTCAGGAAATTCATTCTG GAAAAGCTCGAAGAAGCTAATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACCTACGCTTTTGAGGGAACAGGGTCATTAGCT GGATCCCTGAGCTCCTTAGAATCAGCAGTCTCTGATCAGGATGAAAGCTATGATTACCTTAATGAGTTGGGACCTCGCTTTAAAAGATTA |
* Fusion transcript sequences (Full-length transcript). |
>In-frame_SERPINB5_ENST00000382771_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_5050nt GAACATGTTGGAGGCCTTTTGGAAGCTGTGCAGACAACAGTAACTTCAGCCTGAATCATTTCTTTCAATTGTGGACAAGCTGCCAAGAGG CTTGAGTAGGAGAGGAGTGCCGCCGAGGCGGGGCGGGGCGGGGCGTGGAGCTGGGCTGGCAGTGGGCGTGGCGGTGCTGCCCAGGTGAGC CACCGCTGCTTCTGCCCAGACACGGTCGCCTCCACATCCAGGTCTTTGTGCTCCTCGCTTGCCTGTTCCTTTTCCACGCATTTTCCAGGA TAACTGTGACTCCAGGCCCGCAATGGATGCCCTGCAACTAGCAAATTCGGCTTTTGCCGTTGATCTGTTCAAACAACTATGTGAAAAGGA GCCACTGGGCAATGTCCTCTTCTCTCCAATCTGTCTCTCCACCTCTCTGTCACTTGCTCAAGTGGGTGCTAAAGGTGACACTGCAAATGA AATTGGACAGGTAATTCAGACTATCAGTGCAGTGGATAGAGATGAATCCATAGAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGA CACTAACAATTCAAGTTTTACAATCATAGATAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTTCAAGAAGA ACCTGTCTTCTACATCTCCATCTTAATTGCCGACAATGGAATCCCGTCACTTACAAGTACAAACACCCTTACCATCCATGTCTGTGACTG TGGTGACAGTGGGAGCACACAGACCTGCCAGTACCAGGAGCTTGTGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCTATTCTCAT TTGCATTATGATCATATTTGGGTTTATTTTTTTGACTTTGGGTTTAAAACAACGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGA TTTCAGAGAGAATATATTCCAATATGATGATGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGATATAGCAGAGCTGAGGAGTAGTAC CATAATGCGGGAACGCAAGACTCGGAAAACCACAAGCGCTGAGATCAGGAGCCTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGC CATATTCAGGAAATTCATTCTGGAAAAGCTCGAAGAAGCTAATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACCTACGCTTT TGAGGGAACAGGGTCATTAGCTGGATCCCTGAGCTCCTTAGAATCAGCAGTCTCTGATCAGGATGAAAGCTATGATTACCTTAATGAGTT GGGACCTCGCTTTAAAAGATTAGCATGCATGTTTGGTTCTGCAGTGCAGTCAAATAATTAGGGCTTTTTACCATCAAAATTTTTAAAAGT GCTAATGTGTATTCGAACCCAATGGTAGTCTTAAAGAGTTTTGTGCCCTGGCTCTATGGCGGGGAAAGCCCTAGTCTATGGAGTTTTCTG ATTTCCCTGGAGTAAATACTCCATGGTTATTTTAAGCTACCTACATGCTGTCATTGAACAGAGATGTGGGGAGAAATGTAAACAATCAGC TCACAGGCATCAATACAACCAGATTTGAAGTAAAATAATTTAGGAAGATATTAAAAGTAGATGAGAGGACACAAGATGTAGTCGATCCTT ATGCGATTATATCATTATTTACTTAGGAAAGAGTAAAAATACCAAACGAGAAAATTTAAAGGAGCAAAAATTTGCAAGTCAAATAGAAAT GTACAAATCGAGATAACATTTACATTTCTATCATATTGACATGAAAATTGAAAATGTATAGTCAGAGAAATTTTCATGAATTATTCCATG AAGTATTGTTTCCTTTATTTAAAAAAAAAAAAAAAAAAAAAGAATGCTAGGTAATCTTCGTAGAAAACTAGAAAGTATGATAAACAACAG TTGGAGGAATCCATGGAAAATAGACGAGAAAATGTAAATAAGGCTTTCTGGGGATCACAGAACTTTTGTATGAATAAAAGCCTTATAAAA CCAGCTCTGGCATATGACTAAAATATTCCTCTACTATTTTTCAATGTCATCTAATGCAAACGCTCAACCTTTTTAAATGGTTAATGTGAG AAAGGCACTGAATTAAGATATCTTAGTGTTATTTTATTTACTCAATTTTCATCTTTCACACTGTAAGAATAAAATGTTTTTGTGGTTAAG TTCCTGATACTATATAGAGATAAACTTTAAAACTTTAACACCTAGGATAATGTGGGTGATTACATAAATGTTTAAAAACATTTACCTTAT ATGGAAAGCAGATTTCTGACTAAGATGCCATGATTCATTCTAGTTTGATATTTTAAAACTTTGCCAAGAGCACTCTTTAAAACTGATTTC AAATTTGAACAGATACTTGGTGTATACAAATTAATCAGAGTTATATAGTATAAATTTGTATTATTTTTGATATTACAACTTTGTATTAAA AAGGAAAATATATTTAGGTGTTTGTCATAGATTTTTTTTCATATGCAACTCAAAACACATTCTTATGTCAAAATACAATAGCAAAATACA AGTCAATATTTACTCATAATTAAATGCAAACTTTATGAAACTGGTGGAAAGTGTGGAAAAATTTAAGTAAATTTTTACCTCTACTAAAAA TTATTTAGACAACTTAAAGGAATACTGGATTCAAACTTCAGTTACTATTCACTGTAAATATTATGATCAACTGAACTGACTTACCATTCA TGGGATAAAACATGATACAATTCTCAGTATTTGCTTTTCTGTTAAGAGCTTGGAATATGACTGATGCTTCAGTGTCATTTTTTTATTATT GAATATAAAATTAGGTGCAATAGATACATTTATTGTAGCCTTAAGAAGGAAATCAATGCTAAGCTGTTGGGCATAAAACTTTACAGTAAC ATTAGATAACAAGATAATAAAACACTTTAATTTTAATCGACCTTTTAAGAATGATCTTTATTATTCTATCCAAATCAAGGTAGACTTCAA AATTTATGGTTTGAACAGGAAGAAAGTAGTGAATACAAAATTCTTAAAATTGGTTCATATGATCATTTTTTTATTAATAGCATGTGAGAC TAAGCTGAACCAAACTGGCCATATATGTTAAATCAAATAATTTGAGTAATTTTGAAATATTGATGAAGTAGTTAAATGGTTATAATATAT TTTATTGGTACTTTGAAATTTAAACATCTATATCACATAATAAAGAAAGTTTTTCATCAATCTGAAACAGGCACCATTAAATTGGTGACA CAAATATTATCATTTCACAAAAGCTTGAGAAAACCAGATTTGAAGTGAAATAATTTAGGAAGATATTAAAAGTGGATGAGAGGACATAAG ATGTAGTCAATCCTTAACGCAATGATACCATTATTAGGAAAGAGGAAAAATACCAAACAAGAGAAAATTTAAAGGAGCAAAAATTTGCAA GTCAAATAGAAATGCACAAATCGAGAGAACATTTACATTTCTATCACATTGACATGAAAATTGAAAATGTATAGTCAGAGAAATTTTCAT GAATTATTCCATGAAGTGTTGTTTCCTTTATTTAAAAAGAATGCTAGGTAATCTTAGTAGAAAACTAAAAAGTATGATAAACAACAGATG GAAGAATTCATGGAAAATAGACGAGAAAAAGTAAATAAGGCTTTCTGGAGATGACGGAAATTTTGTATGAATAAAAGCCTTATAAACAAT GAATACATTTGGATAAACAACTCATTAAAATGCACATTAATGGAATACCTGTACAAATAGTTTTAATACTTGTGTCCAGTGGCACTAAAG AGATATATTAAAATAGATTCTGGTTGAGTTGATTATAAGATTGTCAATCATAGGATACACAGGGAAAGCACAGACACGATTGCTCATCTC TTTGGTAGTCTAAAATATGTTCCTTTTAACCACATCAAAAGATACTATCTGATTCTAATACAGAAGGTGCAACTTCCTAGGAATTATACT TTGTATTATATTCAATAATTATTTTATGTTTTGCATCACATGGGTGTTGCAAGAACACAGCTCTTAAACTAAAAAGGCATTACATTAAGA ATTTATTTTTGTAAATTTTAATAAACTCTAAATTAATGCAAAATATTTATGAAAATAGCACAGCTTCACATTAATACCCACAGTACTTAA ATATCTCCCTTAGTTGACTCACAGCTTTGTATGTAAGCTTCAAATTTTTAATGGTAAAAATAAGAAAATTAGGACTAGCGAACTGCTAGT TGTTCCCTCAGTGCATGTGCTTGAGCCTAACAGATCTTTGTTTGAATTAGTTACTTTCAATTAAGCGAACATATAATATTTGTTAAACTG CTTAATCTTTCCAGATCTCACTTTGTAAAATGACGTCCAATCAACCTATTTCACATGGTTGTTATGAAGAATTAATAATAAGATATGTAA AACCAGCAGCACCAATAGTGCCTGACAAAATATAACTGCTCAATAAATAACAGTGAATTATTATAACAACAGCTAATGGTATTCTATTGG AACACATGGTCTGTTTCTTTTCCAATTCTGAGTGATCTCAACAGCCTCACGGCACATTGAAAATAAAAGTCAACTTCCTCACCTTCCCCA TAGGCCATGGACTTTCCCATCTCTACCCACTTGTGCAGTTTCTCCTCTTTCCTCTCTCCTCCTCAGTTACTAAAGCAATCTTCCTTCAAA CACTTCTATTTTCCATTACATCACTTCATTCAGGTTGGTGATCAGCTGCAACTTCCTCAGAAAGACCACTGCTGCTTCCAGTGACCCTGG CTTTGTCTTGCTTTGTATTAGATTACTCAGCTCCCTGGTATTATTGTTGTCTTTATCGCTTATTAGAATGTAACCCTTAATGGGCAAGAA ATTGTCAGTCTTGTTCATTTATCATCGTATAAAAAATGTTTCTAGCACACAGAAAGTGACCAATAAATATTTCTGGAATTAATGTAGTAA TGAATCCAATCTATTTTACTTAGTGACTTGTAGAAATTCTTTTGGTTTCCATTGACTATTTTTATAGAATATTAATATGGAATTAAAGTA >In-frame_SERPINB5_ENST00000489441_chr18_61151829_+_CDH19_ENST00000262150_chr18_64178922_-_4853nt AGACACGGTCGCCTCCACATCCAGGTCTTTGTGCTCCTCGCTTGCCTGTTCCTTTTCCACGCATTTTCCAGGATAACTGTGACTCCAGGC CCGCAATGGATGCCCTGCAACTAGCAAATTCGGCTTTTGCCGTTGATCTGTTCAAACAACTATGTGAAAAGGAGCCACTGGGCAATGTCC TCTTCTCTCCAATCTGTCTCTCCACCTCTCTGTCACTTGCTCAAGTGGGTGCTAAAGGTGACACTGCAAATGAAATTGGACAGGTAATTC AGACTATCAGTGCAGTGGATAGAGATGAATCCATAGAAGAGCACCATTTTTACTTTAATCTATCTGTAGAAGACACTAACAATTCAAGTT TTACAATCATAGATAATCAAGATAACACAGCTGTCATTTTGACTAATAGAACTGGTTTTAACCTTCAAGAAGAACCTGTCTTCTACATCT CCATCTTAATTGCCGACAATGGAATCCCGTCACTTACAAGTACAAACACCCTTACCATCCATGTCTGTGACTGTGGTGACAGTGGGAGCA CACAGACCTGCCAGTACCAGGAGCTTGTGCTTTCCATGGGATTCAAGACAGAAGTCATCATTGCTATTCTCATTTGCATTATGATCATAT TTGGGTTTATTTTTTTGACTTTGGGTTTAAAACAACGGAGAAAACAGATTCTATTTCCTGAGAAAAGTGAAGATTTCAGAGAGAATATAT TCCAATATGATGATGAAGGGGGTGGAGAAGAAGATACAGAGGCCTTTGATATAGCAGAGCTGAGGAGTAGTACCATAATGCGGGAACGCA AGACTCGGAAAACCACAAGCGCTGAGATCAGGAGCCTATACAGGCAGTCTTTGCAAGTTGGCCCCGACAGTGCCATATTCAGGAAATTCA TTCTGGAAAAGCTCGAAGAAGCTAATACTGATCCGTGTGCCCCTCCTTTTGATTCCCTCCAGACCTACGCTTTTGAGGGAACAGGGTCAT TAGCTGGATCCCTGAGCTCCTTAGAATCAGCAGTCTCTGATCAGGATGAAAGCTATGATTACCTTAATGAGTTGGGACCTCGCTTTAAAA GATTAGCATGCATGTTTGGTTCTGCAGTGCAGTCAAATAATTAGGGCTTTTTACCATCAAAATTTTTAAAAGTGCTAATGTGTATTCGAA CCCAATGGTAGTCTTAAAGAGTTTTGTGCCCTGGCTCTATGGCGGGGAAAGCCCTAGTCTATGGAGTTTTCTGATTTCCCTGGAGTAAAT ACTCCATGGTTATTTTAAGCTACCTACATGCTGTCATTGAACAGAGATGTGGGGAGAAATGTAAACAATCAGCTCACAGGCATCAATACA ACCAGATTTGAAGTAAAATAATTTAGGAAGATATTAAAAGTAGATGAGAGGACACAAGATGTAGTCGATCCTTATGCGATTATATCATTA TTTACTTAGGAAAGAGTAAAAATACCAAACGAGAAAATTTAAAGGAGCAAAAATTTGCAAGTCAAATAGAAATGTACAAATCGAGATAAC ATTTACATTTCTATCATATTGACATGAAAATTGAAAATGTATAGTCAGAGAAATTTTCATGAATTATTCCATGAAGTATTGTTTCCTTTA TTTAAAAAAAAAAAAAAAAAAAAAGAATGCTAGGTAATCTTCGTAGAAAACTAGAAAGTATGATAAACAACAGTTGGAGGAATCCATGGA AAATAGACGAGAAAATGTAAATAAGGCTTTCTGGGGATCACAGAACTTTTGTATGAATAAAAGCCTTATAAAACCAGCTCTGGCATATGA CTAAAATATTCCTCTACTATTTTTCAATGTCATCTAATGCAAACGCTCAACCTTTTTAAATGGTTAATGTGAGAAAGGCACTGAATTAAG ATATCTTAGTGTTATTTTATTTACTCAATTTTCATCTTTCACACTGTAAGAATAAAATGTTTTTGTGGTTAAGTTCCTGATACTATATAG AGATAAACTTTAAAACTTTAACACCTAGGATAATGTGGGTGATTACATAAATGTTTAAAAACATTTACCTTATATGGAAAGCAGATTTCT GACTAAGATGCCATGATTCATTCTAGTTTGATATTTTAAAACTTTGCCAAGAGCACTCTTTAAAACTGATTTCAAATTTGAACAGATACT TGGTGTATACAAATTAATCAGAGTTATATAGTATAAATTTGTATTATTTTTGATATTACAACTTTGTATTAAAAAGGAAAATATATTTAG GTGTTTGTCATAGATTTTTTTTCATATGCAACTCAAAACACATTCTTATGTCAAAATACAATAGCAAAATACAAGTCAATATTTACTCAT AATTAAATGCAAACTTTATGAAACTGGTGGAAAGTGTGGAAAAATTTAAGTAAATTTTTACCTCTACTAAAAATTATTTAGACAACTTAA AGGAATACTGGATTCAAACTTCAGTTACTATTCACTGTAAATATTATGATCAACTGAACTGACTTACCATTCATGGGATAAAACATGATA CAATTCTCAGTATTTGCTTTTCTGTTAAGAGCTTGGAATATGACTGATGCTTCAGTGTCATTTTTTTATTATTGAATATAAAATTAGGTG CAATAGATACATTTATTGTAGCCTTAAGAAGGAAATCAATGCTAAGCTGTTGGGCATAAAACTTTACAGTAACATTAGATAACAAGATAA TAAAACACTTTAATTTTAATCGACCTTTTAAGAATGATCTTTATTATTCTATCCAAATCAAGGTAGACTTCAAAATTTATGGTTTGAACA GGAAGAAAGTAGTGAATACAAAATTCTTAAAATTGGTTCATATGATCATTTTTTTATTAATAGCATGTGAGACTAAGCTGAACCAAACTG GCCATATATGTTAAATCAAATAATTTGAGTAATTTTGAAATATTGATGAAGTAGTTAAATGGTTATAATATATTTTATTGGTACTTTGAA ATTTAAACATCTATATCACATAATAAAGAAAGTTTTTCATCAATCTGAAACAGGCACCATTAAATTGGTGACACAAATATTATCATTTCA CAAAAGCTTGAGAAAACCAGATTTGAAGTGAAATAATTTAGGAAGATATTAAAAGTGGATGAGAGGACATAAGATGTAGTCAATCCTTAA CGCAATGATACCATTATTAGGAAAGAGGAAAAATACCAAACAAGAGAAAATTTAAAGGAGCAAAAATTTGCAAGTCAAATAGAAATGCAC AAATCGAGAGAACATTTACATTTCTATCACATTGACATGAAAATTGAAAATGTATAGTCAGAGAAATTTTCATGAATTATTCCATGAAGT GTTGTTTCCTTTATTTAAAAAGAATGCTAGGTAATCTTAGTAGAAAACTAAAAAGTATGATAAACAACAGATGGAAGAATTCATGGAAAA TAGACGAGAAAAAGTAAATAAGGCTTTCTGGAGATGACGGAAATTTTGTATGAATAAAAGCCTTATAAACAATGAATACATTTGGATAAA CAACTCATTAAAATGCACATTAATGGAATACCTGTACAAATAGTTTTAATACTTGTGTCCAGTGGCACTAAAGAGATATATTAAAATAGA TTCTGGTTGAGTTGATTATAAGATTGTCAATCATAGGATACACAGGGAAAGCACAGACACGATTGCTCATCTCTTTGGTAGTCTAAAATA TGTTCCTTTTAACCACATCAAAAGATACTATCTGATTCTAATACAGAAGGTGCAACTTCCTAGGAATTATACTTTGTATTATATTCAATA ATTATTTTATGTTTTGCATCACATGGGTGTTGCAAGAACACAGCTCTTAAACTAAAAAGGCATTACATTAAGAATTTATTTTTGTAAATT TTAATAAACTCTAAATTAATGCAAAATATTTATGAAAATAGCACAGCTTCACATTAATACCCACAGTACTTAAATATCTCCCTTAGTTGA CTCACAGCTTTGTATGTAAGCTTCAAATTTTTAATGGTAAAAATAAGAAAATTAGGACTAGCGAACTGCTAGTTGTTCCCTCAGTGCATG TGCTTGAGCCTAACAGATCTTTGTTTGAATTAGTTACTTTCAATTAAGCGAACATATAATATTTGTTAAACTGCTTAATCTTTCCAGATC TCACTTTGTAAAATGACGTCCAATCAACCTATTTCACATGGTTGTTATGAAGAATTAATAATAAGATATGTAAAACCAGCAGCACCAATA GTGCCTGACAAAATATAACTGCTCAATAAATAACAGTGAATTATTATAACAACAGCTAATGGTATTCTATTGGAACACATGGTCTGTTTC TTTTCCAATTCTGAGTGATCTCAACAGCCTCACGGCACATTGAAAATAAAAGTCAACTTCCTCACCTTCCCCATAGGCCATGGACTTTCC CATCTCTACCCACTTGTGCAGTTTCTCCTCTTTCCTCTCTCCTCCTCAGTTACTAAAGCAATCTTCCTTCAAACACTTCTATTTTCCATT ACATCACTTCATTCAGGTTGGTGATCAGCTGCAACTTCCTCAGAAAGACCACTGCTGCTTCCAGTGACCCTGGCTTTGTCTTGCTTTGTA TTAGATTACTCAGCTCCCTGGTATTATTGTTGTCTTTATCGCTTATTAGAATGTAACCCTTAATGGGCAAGAAATTGTCAGTCTTGTTCA TTTATCATCGTATAAAAAATGTTTCTAGCACACAGAAAGTGACCAATAAATATTTCTGGAATTAATGTAGTAATGAATCCAATCTATTTT |
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FusionGenePPI for SERPINB5_CDH19 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SERPINB5 | HDAC1, UCHL5, ISG15, KHDRBS3, FBXO32, WWOX, HDGFRP2, PLS1, SF3A1, HDLBP, EIF2S2, RAP1BL, ZC3H11A, ALDH2, NARS, ZRANB2, DDX46, EIF2A, UBA6, VRK1, RHOA, HMGCS1, NAA50, CBFB, RAB11B, GPR18, DDX19B, KIR3DS1, UGT1A10, SGOL2, MAPK9, LACC1, PYHIN1, RAB9B, RBM24, ITPA, PPIL3, PRDX6, ADA, C11orf54, GLOD4, SOD1, TPI1, KRAS, AKT1, BCAR3, CASP8, ESR1, PALB2, SMAD4, STK11, XRCC3, MT1H, EEF1A1, COL1A2, TKT, FCF1, TBC1D22B, CCDC82, CDK15, GDF5, CCNYL1, KIAA0907, CPLX3, GPBP1, SYT16, KIF3A, FRMD1, IL31RA, PDE4DIP, ACAD9, FBXL4, SNX3, HSP90AA1, GSTM3, HSPA5, GSTO1, HSP90AB1, TBP, PPIF, MDH1, LRRFIP1, ATIC, BASP1, GOLGA4 | CDH19 | FBXW7, FBXO45, CSRP2BP, MARK1, YEATS2, KLHDC3, MYCBP2, ZZZ3, TADA2A, MARK3, DDX11, MBIP, C15orf39, TADA3, TPP2, L3MBTL2, UBB, SETX, MGA, PUSL1, TOP2A, NCAPG, MARK2, PML |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SERPINB5_CDH19 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SERPINB5_CDH19 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SERPINB5 | C0009375 | Colonic Neoplasms | 1 | CTD_human |
Hgene | SERPINB5 | C0009404 | Colorectal Neoplasms | 1 | CTD_human |
Hgene | SERPINB5 | C0022548 | Keloid | 1 | CTD_human |
Hgene | SERPINB5 | C0027627 | Neoplasm Metastasis | 1 | CTD_human |
Hgene | SERPINB5 | C1134719 | Invasive Ductal Breast Carcinoma | 1 | CTD_human |
Hgene | SERPINB5 | C1458155 | Mammary Neoplasms | 1 | CTD_human |