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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33297

FusionGeneSummary for SERPINA3_SERPINA3

check button Fusion gene summary
Fusion gene informationFusion gene name: SERPINA3_SERPINA3
Fusion gene ID: 33297
HgeneTgene
Gene symbol

SERPINA3

SERPINA3

Gene ID

12

12

Gene nameserpin family A member 3serpin family A member 3
SynonymsAACT|ACT|GIG24|GIG25AACT|ACT|GIG24|GIG25
Cytomap

14q32.13

14q32.13

Type of geneprotein-codingprotein-coding
Descriptionalpha-1-antichymotrypsincell growth-inhibiting gene 24/25 proteingrowth-inhibiting protein 24growth-inhibiting protein 25serine (or cysteine) proteinase inhibitor, clade A, member 3serpin A3serpin peptidase inhibitor, clade A (alpha-1 antiproteinasealpha-1-antichymotrypsincell growth-inhibiting gene 24/25 proteingrowth-inhibiting protein 24growth-inhibiting protein 25serine (or cysteine) proteinase inhibitor, clade A, member 3serpin A3serpin peptidase inhibitor, clade A (alpha-1 antiproteinase
Modification date2018052320180523
UniProtAcc

P01011

P01011

Ensembl transtripts involved in fusion geneENST00000393078, ENST00000485588, 
ENST00000393080, ENST00000467132, 
ENST00000482740, 		ENST00000393078, 
ENST00000485588, ENST00000393080, 
ENST00000467132, ENST00000482740, 
Fusion gene scores* DoF score6 X 8 X 4=1924 X 6 X 1=24
# samples 108
** MAII scorelog2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/24*10)=1.73696559416621
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SERPINA3 [Title/Abstract] AND SERPINA3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE813446SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
ChiTaRS3.1AW994810SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
ChiTaRS3.1BE813450SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
ChiTaRS3.1BF924119SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
ChiTaRS3.1BF326784SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000393078ENST00000393078SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-intronENST00000393078ENST00000485588SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393078ENST00000393080SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393078ENST00000467132SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393078ENST00000482740SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
intron-3UTRENST00000485588ENST00000393078SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
intron-intronENST00000485588ENST00000485588SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
intron-3UTRENST00000485588ENST00000393080SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
intron-3UTRENST00000485588ENST00000467132SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
intron-3UTRENST00000485588ENST00000482740SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393080ENST00000393078SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-intronENST00000393080ENST00000485588SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393080ENST00000393080SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393080ENST00000467132SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000393080ENST00000482740SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000467132ENST00000393078SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-intronENST00000467132ENST00000485588SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000467132ENST00000393080SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000467132ENST00000467132SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000467132ENST00000482740SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000482740ENST00000393078SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-intronENST00000482740ENST00000485588SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000482740ENST00000393080SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000482740ENST00000467132SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
5CDS-3UTRENST00000482740ENST00000482740SERPINA3chr14

95090096

-SERPINA3chr14

95090209

+
Frame-shiftENST00000393078ENST00000393078SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393078ENST00000485588SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393078ENST00000393080SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393078ENST00000467132SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393078ENST00000482740SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-3CDSENST00000485588ENST00000393078SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000485588ENST00000485588SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000485588ENST00000393080SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000485588ENST00000467132SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000485588ENST00000482740SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
Frame-shiftENST00000393080ENST00000393078SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393080ENST00000485588SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393080ENST00000393080SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393080ENST00000467132SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000393080ENST00000482740SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
Frame-shiftENST00000467132ENST00000393078SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000467132ENST00000485588SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000467132ENST00000393080SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000467132ENST00000467132SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
5CDS-intronENST00000467132ENST00000482740SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-3CDSENST00000482740ENST00000393078SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000482740ENST00000485588SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000482740ENST00000393080SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000482740ENST00000467132SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
intron-intronENST00000482740ENST00000482740SERPINA3chr14

95081225

-SERPINA3chr14

95088754

-
3UTR-3CDSENST00000393078ENST00000393078SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393078ENST00000485588SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393078ENST00000393080SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393078ENST00000467132SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393078ENST00000482740SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
intron-3CDSENST00000485588ENST00000393078SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
intron-intronENST00000485588ENST00000485588SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
intron-intronENST00000485588ENST00000393080SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
intron-intronENST00000485588ENST00000467132SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
intron-intronENST00000485588ENST00000482740SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-3CDSENST00000393080ENST00000393078SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393080ENST00000485588SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393080ENST00000393080SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393080ENST00000467132SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000393080ENST00000482740SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-3CDSENST00000467132ENST00000393078SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000467132ENST00000485588SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000467132ENST00000393080SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000467132ENST00000467132SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000467132ENST00000482740SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-3CDSENST00000482740ENST00000393078SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000482740ENST00000485588SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000482740ENST00000393080SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000482740ENST00000467132SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+
3UTR-intronENST00000482740ENST00000482740SERPINA3chr14

95090209

-SERPINA3chr14

95090096

+

Top

FusionProtFeatures for SERPINA3_SERPINA3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERPINA3

P01011

SERPINA3

P01011


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SERPINA3_SERPINA3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SERPINA3_SERPINA3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SERPINA3_SERPINA3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSERPINA3P01011DB01593ZincAlpha-1-antichymotrypsinsmall moleculeapproved|investigational
TgeneSERPINA3P01011DB01593ZincAlpha-1-antichymotrypsinsmall moleculeapproved|investigational

Top

RelatedDiseases for SERPINA3_SERPINA3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERPINA3C0023794Lipoidosis3CTD_human
HgeneSERPINA3C0033578Prostatic Neoplasms1CTD_human
HgeneSERPINA3C0033975Psychotic Disorders1PSYGENET
HgeneSERPINA3C0349204Nonorganic psychosis1PSYGENET
TgeneSERPINA3C0023794Lipoidosis3CTD_human
TgeneSERPINA3C0033578Prostatic Neoplasms1CTD_human
TgeneSERPINA3C0033975Psychotic Disorders1PSYGENET
TgeneSERPINA3C0349204Nonorganic psychosis1PSYGENET