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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33264

FusionGeneSummary for SERINC5_ZFYVE16

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC5_ZFYVE16
Fusion gene ID: 33264
HgeneTgene
Gene symbol

SERINC5

ZFYVE16

Gene ID

256987

9765

Gene nameserine incorporator 5zinc finger FYVE-type containing 16
SynonymsC5orf12|TPO1PPP1R69
Cytomap

5q14.1

5q14.1

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 5zinc finger FYVE domain-containing protein 16endosome-associated FYVE-domain proteinprotein phosphatase 1, regulatory subunit 69zinc finger, FYVE domain containing 16
Modification date2018052320180523
UniProtAcc

Q86VE9

Q7Z3T8

Ensembl transtripts involved in fusion geneENST00000507668, ENST00000512972, 
ENST00000509193, ENST00000512721, 
ENST00000513907, 		ENST00000338008, 
ENST00000510158, ENST00000505560, 
ENST00000512442, 
Fusion gene scores* DoF score7 X 5 X 5=1753 X 4 X 3=36
# samples 63
** MAII scorelog2(6/175*10)=-1.54432051622381
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/36*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERINC5 [Title/Abstract] AND ZFYVE16 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERINC5

GO:0009597

detection of virus

26416733|26416734

HgeneSERINC5

GO:0045087

innate immune response

26416733|26416734

HgeneSERINC5

GO:0051607

defense response to virus

26416733|26416734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVKIRCTCGA-BP-5202-01ASERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
TCGALDKIRCTCGA-BP-5202-01ASERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000507668ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000507668ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-5UTRENST00000507668ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000507668ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512972ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512972ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-5UTRENST00000512972ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512972ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000509193ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000509193ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-5UTRENST00000509193ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000509193ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512721ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512721ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-5UTRENST00000512721ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-intronENST00000512721ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5UTR-intronENST00000513907ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5UTR-intronENST00000513907ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5UTR-5UTRENST00000513907ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5UTR-intronENST00000513907ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79723311

+
5CDS-5UTRENST00000507668ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000507668ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000507668ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-intronENST00000507668ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512972ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512972ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512972ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-intronENST00000512972ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000509193ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000509193ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000509193ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-intronENST00000509193ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512721ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512721ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-5UTRENST00000512721ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5CDS-intronENST00000512721ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5UTR-5UTRENST00000513907ENST00000338008SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5UTR-5UTRENST00000513907ENST00000510158SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5UTR-5UTRENST00000513907ENST00000505560SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+
5UTR-intronENST00000513907ENST00000512442SERINC5chr5

79498705

-ZFYVE16chr5

79729928

+

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FusionProtFeatures for SERINC5_ZFYVE16


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERINC5

Q86VE9

ZFYVE16

Q7Z3T8

Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734). Enhancesthe incorporation of serine into phosphatidylserine andsphingolipids. May play a role in providing serine molecules forthe formation of myelin glycosphingolipids in oligodendrocytes (Bysimilarity). {ECO:0000250|UniProtKB:Q63175,ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}. May be involved in regulating membrane trafficking inthe endosomal pathway. Overexpression induces endosomeaggregation. Required to target TOM1 to endosomes.{ECO:0000269|PubMed:11546807, ECO:0000269|PubMed:14613930}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SERINC5_ZFYVE16


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SERINC5_ZFYVE16


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SERINC5TRIM25ZFYVE16TOM1, APP, PSMC3, PPP1CA, RNF11, PPP1CC, MED4, CDH1, PTPN23


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERINC5_ZFYVE16


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERINC5_ZFYVE16


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZFYVE16C0023893Liver Cirrhosis, Experimental1CTD_human