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Fusion gene ID: 33263 |
FusionGeneSummary for SERINC5_TTC39A |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SERINC5_TTC39A | Fusion gene ID: 33263 | Hgene | Tgene | Gene symbol | SERINC5 | TTC39A | Gene ID | 256987 | 22996 |
| Gene name | serine incorporator 5 | tetratricopeptide repeat domain 39A | |
| Synonyms | C5orf12|TPO1 | C1orf34|DEME-6 | |
| Cytomap | 5q14.1 | 1p32.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine incorporator 5 | tetratricopeptide repeat protein 39ATPR repeat protein 39Adifferentially expressed in MCF7 with estradiol protein 6testicular tissue protein Li 213 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q86VE9 | Q5SRH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000507668, ENST00000512972, ENST00000509193, ENST00000512721, ENST00000513907, | ENST00000447632, ENST00000413473, ENST00000262675, ENST00000451380, ENST00000371750, ENST00000371747, ENST00000262676, ENST00000530004, ENST00000534098, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 5 X 4 X 3=60 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SERINC5 [Title/Abstract] AND TTC39A [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SERINC5 | GO:0009597 | detection of virus | 26416733|26416734 |
| Hgene | SERINC5 | GO:0045087 | innate immune response | 26416733|26416734 |
| Hgene | SERINC5 | GO:0051607 | defense response to virus | 26416733|26416734 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | PRAD | TCGA-CH-5771-01A | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000507668 | ENST00000447632 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| Frame-shift | ENST00000507668 | ENST00000413473 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000507668 | ENST00000262675 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000507668 | ENST00000451380 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000507668 | ENST00000371750 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000507668 | ENST00000371747 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000507668 | ENST00000262676 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000507668 | ENST00000530004 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000507668 | ENST00000534098 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| In-frame | ENST00000512972 | ENST00000447632 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| In-frame | ENST00000512972 | ENST00000413473 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512972 | ENST00000262675 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512972 | ENST00000451380 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512972 | ENST00000371750 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512972 | ENST00000371747 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512972 | ENST00000262676 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000512972 | ENST00000530004 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000512972 | ENST00000534098 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| Frame-shift | ENST00000509193 | ENST00000447632 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| Frame-shift | ENST00000509193 | ENST00000413473 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000509193 | ENST00000262675 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000509193 | ENST00000451380 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000509193 | ENST00000371750 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000509193 | ENST00000371747 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000509193 | ENST00000262676 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000509193 | ENST00000530004 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000509193 | ENST00000534098 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| Frame-shift | ENST00000512721 | ENST00000447632 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| Frame-shift | ENST00000512721 | ENST00000413473 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512721 | ENST00000262675 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512721 | ENST00000451380 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512721 | ENST00000371750 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512721 | ENST00000371747 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-5UTR | ENST00000512721 | ENST00000262676 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000512721 | ENST00000530004 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| 5CDS-intron | ENST00000512721 | ENST00000534098 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-3CDS | ENST00000513907 | ENST00000447632 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-3CDS | ENST00000513907 | ENST00000413473 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-5UTR | ENST00000513907 | ENST00000262675 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-5UTR | ENST00000513907 | ENST00000451380 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-5UTR | ENST00000513907 | ENST00000371750 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-5UTR | ENST00000513907 | ENST00000371747 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-5UTR | ENST00000513907 | ENST00000262676 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-intron | ENST00000513907 | ENST00000530004 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
| intron-intron | ENST00000513907 | ENST00000534098 | SERINC5 | chr5 | 79462206 | - | TTC39A | chr1 | 51787497 | - |
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FusionProtFeatures for SERINC5_TTC39A |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SERINC5 | TTC39A |
| Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734). Enhancesthe incorporation of serine into phosphatidylserine andsphingolipids. May play a role in providing serine molecules forthe formation of myelin glycosphingolipids in oligodendrocytes (Bysimilarity). {ECO:0000250|UniProtKB:Q63175,ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SERINC5_TTC39A |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000447632_chr1_51787497_-_885aa MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSA VYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKW NKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSGLLQSGVISCY VTYLTFSALSSKPAEVGLLRAASMRPWTSAXPPWTSSSPTSSQKHSATSSPEPRKACTTHXHMPPSWRCRPXXPLTLRTSCLPATXXRRH RCCVRGTGGSLLXQIPSAAWXTAPRWANSLKRKSTLRSAMQSACCSEQPXPSCRVPHTEGQSGPEPCMIPLTPAAAHLGQAVSIFSSCRT RTWXASSKAASKFETATRPTRSWTALFSPHNTARVRTTRTLKEEXSLVXGPSTXHCPCFLLGSXGCWSLWGFQETRTMGCCSWRRERQGT ASALCSVSCSCCATTPSSPSCSVLGTSTSRRPRSSXSPTXTGTLRVPSSCSLQGGLKSLKATLMQPSGVSRSAVRPSSTGSSSTTCATGS XCGASPTRASGRCPTSTPTCSARRTAGPRPPTFTXRPPTSACLGRRTTSRSGTTKWNYFELCQAXSSRLLGNLYPQRSLPSGSPGATSPP TLSRCQCLLWKXCTSGTATPXLGSSRNSRMGYLRLSLRLKRCWRKAQRTSTQWMTSAWXNCXKACVXNTWAVSRRPRRILGASLPMKRRL >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000413473_chr1_51787497_-_850aa MSAQCCAGQLACCCGSAGCSLCCDCCPRIRQSLSTRFMYALYFILVVVLCCIMMSTTVAHKMKEHIPFFEDMCKGIKAGDTCEKLVGYSA VYRVCFGMACFFFIFCLLTLKINNSKSCRAHIHNGFWFFKLLLLGAMCSGAFFIPDQDTFLNAWRYVGAVGGFLFIGIQLLLLVEFAHKW NKNWTAGTASNKLWYASLALVTLIMYSIATGGLVLMAVFYTQKDSCMENKILLGVNGGLCLLISLVAISPWVQNRQPHSGLLQSGVISCY VTYLTFSALSSKPAEVGLLRAASMRPWTSAXPPWTSSSPTSSQKHSATSSPEPRKACTTHXHMPPSWRCRPXXPLTLRTSCLPATXXRRH RCCVRGTGGSLLXQIPSAAWXTAPRWANSLKRKSTLRSAMQSACCSEQPXPSCRTRTWXASSKAASKFETATRPTRSWTALFSPHNTARV RTTRTLKEEXSLVXGPSTXHCPCFLLGSXGCWSLWGFQETRTMGCCSWRRERQGTASALCSVSCSCCATTPSSPSCSVLGTSTSRRPRSS XSPTXTGTLRVPSSCSLQGGLKSLKATLMQPSGVSRSAVRPSSTGSSSTTCATGSXCGASPTRASGRCPTSTPTCSARRTAGPRPPTFTX RPPTSACLGRRTTSRSGTTKWNYFELCQAXSSRLLGNLYPQRSLPSGSPGATSPPTLSRCQCLLWKXCTSGTATPXLGSSRNSRMGYLRL SLRLKRCWRKAQRTSTQWMTSAWXNCXKACVXNTWAVSRRPRRILGASLPMKRRLNMTTTXSQTPCWSWPCCLWSKTETKRPSNFWNLPS |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000447632_chr1_51787497_-_2657nt ATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAGGATTCGG CAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGTGGCTCAC AAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATATTCTGCC GTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTGTAGAGCT CATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGACACCTTT CTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACATAAGTGG AACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCATTGCCACT GGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGGCCTGTGC CTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAGCTGCTAT GTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCA TGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTACCACTCAC TGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAGGAGGCAC AGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAATTCACTG AAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGGTTCCTCACACGGAGGGG CAGTCAGGCCCAGAGCCTTGCATGATCCCTCTCACGCCTGCAGCTGCCCACCTGGGCCAGGCCGTCAGCATCTTTTCCTCCTGCAGGACG AGAACATGGTGAGCTTCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAGTCCTCAC AATACTGCAAGGGTGAGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATGCTTCCTA CTAGGATCCTGAGGCTGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCAGGGCACA GCTTCCGCTCTGTGCTCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAACATCGAGG AGGCCGAGAAGCTCTTGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTCATTAAAG GCAACATTGATGCAGCCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTACTGGGAGC TGATGTGGTGCTTCACCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCCAAGGCCA CCTACATTTACATGAAGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTATTTCGAG CTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTCTCCTCCA ACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTCACGGATG GGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTGGTGAAAT TGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAGAAGATTA AATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATCAAACTTT TGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCCAAGTCTT >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000413473_chr1_51787497_-_2552nt ATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAGGATTCGG CAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGTGGCTCAC AAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATATTCTGCC GTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTGTAGAGCT CATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGACACCTTT CTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACATAAGTGG AACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCATTGCCACT GGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGGCCTGTGC CTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAGCTGCTAT GTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGACCAGTGCA TGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTACCACTCAC TGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAGGAGGCAC AGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAATTCACTG AAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGACGAGAACATGGTGAGCT TCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAGTCCTCACAATACTGCAAGGGTG AGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATGCTTCCTACTAGGATCCTGAGGC TGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCAGGGCACAGCTTCCGCTCTGTGC TCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAACATCGAGGAGGCCGAGAAGCTCT TGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTCATTAAAGGCAACATTGATGCAG CCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTACTGGGAGCTGATGTGGTGCTTCA CCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCCAAGGCCACCTACATTTACATGA AGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTATTTCGAGCTGTGCCAGGCCTGA AGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATCTCGCTGC CAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTTGAGATTA TCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAAGGCCTGT GTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGACCACTACT TGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCTGCCAAGC AAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAGAACAGCA |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000447632_chr1_51787497_-_3653nt AGCTGCGGCTGAGCCCAGCGCTCGAGGCGCGAGGCAGCCAGGAGGGCCCGTGCGGCGCGGGGAGCCAGCGAGCGCGCCTTCGGCATTGGC CGCCGCGATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAG GATTCGGCAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGT GGCTCACAAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATA TTCTGCCGTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTG TAGAGCTCATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGA CACCTTTCTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACA TAAGTGGAACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCAT TGCCACTGGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGG CCTGTGCCTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAG CTGCTATGTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGAC CAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTAC CACTCACTGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAG GAGGCACAGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAA TTCACTGAAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGGTTCCTCACAC GGAGGGGCAGTCAGGCCCAGAGCCTTGCATGATCCCTCTCACGCCTGCAGCTGCCCACCTGGGCCAGGCCGTCAGCATCTTTTCCTCCTG CAGGACGAGAACATGGTGAGCTTCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAG TCCTCACAATACTGCAAGGGTGAGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATG CTTCCTACTAGGATCCTGAGGCTGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCA GGGCACAGCTTCCGCTCTGTGCTCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAAC ATCGAGGAGGCCGAGAAGCTCTTGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTC ATTAAAGGCAACATTGATGCAGCCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTAC TGGGAGCTGATGTGGTGCTTCACCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCC AAGGCCACCTACATTTACATGAAGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTA TTTCGAGCTGTGCCAGGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTC TCCTCCAACCCTATCTCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTC ACGGATGGGATACTTGAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTG GTGAAATTGTTGAAAGGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAG AAGATTAAATATGACCACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATC AAACTTTTGGAATCTGCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCC AAGTCTTCCCTAGAGAACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAGCAGTTCCGGGCTGGAAGACAGAGACA GCTGGACAGAGCTCCTGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGGGTCCACCGGCACTCCAGTTGGATGGC ACAACATAGTGTATCCGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTGCCAAGGGCAGAGCAGGTGGAGCCCTC TGCCTGCCCTATCACACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAACAGTTTACATTTTCCTTAGAAATACAT TGATGGGATCACAGTTGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCACCTATTATCATCTGGAGGTAAATCTC TTTATATGATGATGCCAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGACGGAAGGTCCTTCAGAGGACCTGAGGA ATGCCTGGGAGAGGCTAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACAGACACCCACTACCTTACTACTCACAC TTCATTTCACTCCTTTTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAAATCTGAGCTCTTCTGTAGAAAAATCA ATCTCTACCAGTAGAAAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAGCCAGGAAATTTGGGGGGCAGGAGGAG GTTCTCAGAATCCAGTCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATGAAACATAAAAATCTTCTGTACTTCAC >In-frame_SERINC5_ENST00000512972_chr5_79462206_-_TTC39A_ENST00000413473_chr1_51787497_-_3548nt AGCTGCGGCTGAGCCCAGCGCTCGAGGCGCGAGGCAGCCAGGAGGGCCCGTGCGGCGCGGGGAGCCAGCGAGCGCGCCTTCGGCATTGGC CGCCGCGATGTCAGCTCAGTGCTGTGCGGGCCAGCTGGCCTGCTGCTGTGGGTCTGCAGGCTGCTCTCTCTGCTGTGATTGCTGCCCCAG GATTCGGCAGTCCCTCAGCACCCGCTTCATGTACGCCCTCTACTTCATTCTGGTCGTCGTCCTCTGCTGCATCATGATGTCAACAACCGT GGCTCACAAGATGAAAGAGCACATTCCTTTTTTTGAAGATATGTGTAAAGGCATTAAAGCTGGTGACACCTGTGAGAAGCTGGTGGGATA TTCTGCCGTGTATAGAGTCTGTTTTGGAATGGCTTGTTTCTTCTTTATCTTCTGTCTACTGACCTTGAAAATCAACAACAGCAAAAGTTG TAGAGCTCATATTCACAATGGCTTTTGGTTCTTTAAACTTCTGCTGTTGGGGGCCATGTGCTCAGGAGCTTTCTTCATTCCAGATCAGGA CACCTTTCTGAACGCCTGGCGCTATGTGGGAGCCGTCGGAGGCTTCCTCTTCATTGGCATCCAGCTCCTCCTGCTCGTGGAGTTTGCACA TAAGTGGAACAAGAACTGGACAGCAGGCACAGCCAGTAACAAGCTGTGGTACGCCTCCCTGGCCCTGGTGACGCTCATCATGTATTCCAT TGCCACTGGAGGCTTGGTTTTGATGGCAGTGTTTTATACACAGAAAGACAGCTGCATGGAAAACAAAATTCTGCTGGGAGTAAATGGAGG CCTGTGCCTGCTTATATCATTGGTAGCCATCTCACCCTGGGTCCAAAATCGACAGCCACACTCGGGGCTCTTACAATCAGGGGTCATAAG CTGCTATGTCACCTACCTCACCTTCTCAGCTCTGTCCAGCAAACCTGCAGAAGTAGGACTCCTGAGAGCAGCCTCCATGAGGCCCTGGAC CAGTGCATGACCGCCCTGGACCTCTTCCTCACCAACCAGTTCTCAGAAGCACTCAGCTACCTCAAGCCCAGAACCAAGGAAAGCATGTAC CACTCACTGACATATGCCACCATCCTGGAGATGCAGGCCATGATGACCTTTGACCCTCAGGACATCCTGCTTGCCGGCAACATGATGAAG GAGGCACAGATGCTGTGTCAGAGGCACCGGAGGAAGTCTTCTGTAACAGATTCCTTCAGCAGCCTGGTGAACCGCCCCACGCTGGGCCAA TTCACTGAAGAGGAAATCCACGCTGAGGTCTGCTATGCAGAGTGCCTGCTGCAGCGAGCAGCCCTGACCTTCCTGCAGGACGAGAACATG GTGAGCTTCATCAAAGGCGGCATCAAAGTTCGAAACAGCTACCAGACCTACAAGGAGCTGGACAGCCTTGTTCAGTCCTCACAATACTGC AAGGGTGAGAACCACCCGCACTTTGAAGGAGGAGTGAAGCTTGGTGTAGGGGCCTTCAACCTGACACTGTCCATGCTTCCTACTAGGATC CTGAGGCTGTTGGAGTTTGTGGGGTTTTCAGGAAACAAGGACTATGGGCTGCTGCAGCTGGAGGAGGGAGCGTCAGGGCACAGCTTCCGC TCTGTGCTCTGTGTCATGCTCCTGCTGTGCTACCACACCTTCCTCACCTTCGTGCTCGGTACTGGGAACGTCAACATCGAGGAGGCCGAG AAGCTCTTGAAGCCCTACCTGAACCGGTACCCTAAGGGTGCCATCTTCCTGTTCTTTGCAGGGAGGATTGAAGTCATTAAAGGCAACATT GATGCAGCCATCCGGCGTTTCGAGGAGTGCTGTGAGGCCCAGCAGCACTGGAAGCAGTTCCACCACATGTGCTACTGGGAGCTGATGTGG TGCTTCACCTACAAGGGCCAGTGGAAGATGTCCTACTTCTACGCCGACCTGCTCAGCAAGGAGAACTGCTGGTCCAAGGCCACCTACATT TACATGAAGGCCGCCTACCTCAGCATGTTTGGGAAGGAGGACCACAAGCCGTTCGGGGACGACGAAGTGGAATTATTTCGAGCTGTGCCA GGCCTGAAGCTCAAGATTGCTGGGAAATCTCTACCCACAGAGAAGTTTGCCATCCGGAAGTCCCGGCGCTACTTCTCCTCCAACCCTATC TCGCTGCCAGTGCCTGCTCTGGAAATGATGTACATCTGGAACGGCTACGCCGTGATTGGGAAGCAGCCGAAACTCACGGATGGGATACTT GAGATTATCACTAAGGCTGAAGAGATGCTGGAGAAAGGCCCAGAGAACGAGTACTCAGTGGATGACGAGTGCTTGGTGAAATTGTTGAAA GGCCTGTGTCTGAAATACCTGGGCCGTGTCCAGGAGGCCGAGGAGAATTTTAGGAGCATCTCTGCCAATGAAAAGAAGATTAAATATGAC CACTACTTGATCCCAAACGCCCTGCTGGAGCTGGCCCTGCTGCTTATGGAGCAAGACAGAAACGAAGAGGCCATCAAACTTTTGGAATCT GCCAAGCAAAACTACAAGAATTACTCCATGGAGTCAAGGACACACTTTCGAATCCAGGCAGCCACACTCCAAGCCAAGTCTTCCCTAGAG AACAGCAGCAGATCCATGGTCTCATCAGTGTCCTTGTAGCTTTGTGCAGCAGTTCCGGGCTGGAAGACAGAGACAGCTGGACAGAGCTCC TGAAAACATTTCAAAATACCCCCTCCCCCTGCCCTGCCCTGCCTTTGGGGTCCACCGGCACTCCAGTTGGATGGCACAACATAGTGTATC CGTGCAGAAGCCGAGCTGGCATTTTCACCAGTGTAGCCAAGGGCCTTTGCCAAGGGCAGAGCAGGTGGAGCCCTCTGCCTGCCCTATCAC ACATACGGGTACTTGCTTTTCACTGTGATGTTTAAGAGAATGTATGAACAGTTTACATTTTCCTTAGAAATACATTGATGGGATCACAGT TGGCTTTAAAAACCAACAACAATCAACCACCTGTAAGTCTTTGTCTTCACCTATTATCATCTGGAGGTAAATCTCTTTATATGATGATGC CAAAGGGCAAATTGCTTTTCAAATTCAGCAAGTTCTCAGCTTGTGTGACGGAAGGTCCTTCAGAGGACCTGAGGAATGCCTGGGAGAGGC TAAGCCTCAGGCTTCAATGCTTCTGGGGTTGGGCATGAGGATGTACACAGACACCCACTACCTTACTACTCACACTTCATTTCACTCCTT TTGTAAATTTCCAATTTAAAAATCAAGCACGTCTTTTTAGTGAGATAAAATCTGAGCTCTTCTGTAGAAAAATCAATCTCTACCAGTAGA AAATGCCAGGGCTTGATGGAAGAGCTGTGTAGCCCTTTCTATGCCAAAGCCAGGAAATTTGGGGGGCAGGAGGAGGTTCTCAGAATCCAG TCTGTATCTTTGCTGTATGCCAAACTGAAACCACTGGGAATAATTTATGAAACATAAAAATCTTCTGTACTTCACTCCAAGGTACATTTG |
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FusionGenePPI for SERINC5_TTC39A |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SERINC5 | TRIM25 | TTC39A | P2RY12 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SERINC5_TTC39A |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SERINC5_TTC39A |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | TTC39A | C0023903 | Liver neoplasms | 1 | CTD_human |
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