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Fusion gene ID: 33262 |
FusionGeneSummary for SERINC5_THBS4 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SERINC5_THBS4 | Fusion gene ID: 33262 | Hgene | Tgene | Gene symbol | SERINC5 | THBS4 | Gene ID | 256987 | 7060 |
| Gene name | serine incorporator 5 | thrombospondin 4 | |
| Synonyms | C5orf12|TPO1 | TSP-4|TSP4 | |
| Cytomap | 5q14.1 | 5q14.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | serine incorporator 5 | thrombospondin-4 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | Q86VE9 | P35443 | |
| Ensembl transtripts involved in fusion gene | ENST00000507668, ENST00000512972, ENST00000509193, ENST00000512721, ENST00000513907, | ENST00000350881, ENST00000511733, ENST00000504720, | |
| Fusion gene scores | * DoF score | 7 X 5 X 5=175 | 1 X 1 X 1=1 |
| # samples | 6 | 1 | |
| ** MAII score | log2(6/175*10)=-1.54432051622381 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SERINC5 [Title/Abstract] AND THBS4 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SERINC5 | GO:0009597 | detection of virus | 26416733|26416734 |
| Hgene | SERINC5 | GO:0045087 | innate immune response | 26416733|26416734 |
| Hgene | SERINC5 | GO:0051607 | defense response to virus | 26416733|26416734 |
| Tgene | THBS4 | GO:0001938 | positive regulation of endothelial cell proliferation | 12952849 |
| Tgene | THBS4 | GO:0050731 | positive regulation of peptidyl-tyrosine phosphorylation | 16099885 |
| Tgene | THBS4 | GO:0051451 | myoblast migration | 7519904 |
| Tgene | THBS4 | GO:0071603 | endothelial cell-cell adhesion | 12952849 |
| Tgene | THBS4 | GO:0090023 | positive regulation of neutrophil chemotaxis | 16099885 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUSC | TCGA-77-7142-01A | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000507668 | ENST00000350881 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| Frame-shift | ENST00000507668 | ENST00000511733 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| 5CDS-intron | ENST00000507668 | ENST00000504720 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| In-frame | ENST00000512972 | ENST00000350881 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| In-frame | ENST00000512972 | ENST00000511733 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| 5CDS-intron | ENST00000512972 | ENST00000504720 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| Frame-shift | ENST00000509193 | ENST00000350881 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| Frame-shift | ENST00000509193 | ENST00000511733 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| 5CDS-intron | ENST00000509193 | ENST00000504720 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| In-frame | ENST00000512721 | ENST00000350881 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| In-frame | ENST00000512721 | ENST00000511733 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| 5CDS-intron | ENST00000512721 | ENST00000504720 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| intron-3CDS | ENST00000513907 | ENST00000350881 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| intron-3CDS | ENST00000513907 | ENST00000511733 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
| intron-intron | ENST00000513907 | ENST00000504720 | SERINC5 | chr5 | 79470777 | - | THBS4 | chr5 | 79372678 | + |
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FusionProtFeatures for SERINC5_THBS4 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SERINC5 | THBS4 |
| Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734). Enhancesthe incorporation of serine into phosphatidylserine andsphingolipids. May play a role in providing serine molecules forthe formation of myelin glycosphingolipids in oligodendrocytes (Bysimilarity). {ECO:0000250|UniProtKB:Q63175,ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}. | Adhesive glycoprotein that mediates cell-to-cell andcell-to-matrix interactions and is involved in various processesincluding cellular proliferation, migration, adhesion andattachment, inflammatory response to CNS injury, regulation ofvascular inflammation and adaptive responses of the heart topressure overload and in myocardial function and remodeling. Bindsto structural extracellular matrix (ECM) proteins and modulatesthe ECM in response to tissue damage, contributing tocardioprotective and adaptive ECM remodeling. Plays a role in ERstress response, via its interaction with the activatingtranscription factor 6 alpha (ATF6) which produces adaptive ERstress response factors and protects myocardium from pressureoverload. May contribute to spinal presynaptic hypersensitivityand neuropathic pain states after peripheral nerve injury. Mayplay a role in regulating protective astrogenesis from thesubventricular zone (SVZ) niche after injury in a NOTCH1-dependentmanner (By similarity). {ECO:0000250,ECO:0000269|PubMed:19441079}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SERINC5_THBS4 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SERINC5_THBS4 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SERINC5 | TRIM25 | THBS4 | THBS3, APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SERINC5_THBS4 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SERINC5_THBS4 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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