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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33257

FusionGeneSummary for SERINC3_WFDC11

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC3_WFDC11
Fusion gene ID: 33257
HgeneTgene
Gene symbol

SERINC3

WFDC11

Gene ID

10955

259239

Gene nameserine incorporator 3WAP four-disulfide core domain 11
SynonymsAIGP1|DIFF33|SBBI99|TDE|TDE1|TMS-1WAP11
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 3tumor differentially expressed protein 1protein WFDC11protease inhibitor WAP11
Modification date2018052320180329
UniProtAcc

Q13530

Q8NEX6

Ensembl transtripts involved in fusion geneENST00000255175, ENST00000342374, 
ENST00000541235, ENST00000468234, 
ENST00000356562, ENST00000324384, 
Fusion gene scores* DoF score5 X 5 X 4=1002 X 1 X 2=4
# samples 52
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/4*10)=2.32192809488736
Context

PubMed: SERINC3 [Title/Abstract] AND WFDC11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERINC3

GO:0009597

detection of virus

26416733|26416734

HgeneSERINC3

GO:0045087

innate immune response

26416733|26416734

HgeneSERINC3

GO:0051607

defense response to virus

26416733|26416734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDCOADTCGA-CM-6170-01ASERINC3chr20

43138532

-WFDC11chr20

44279290

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000255175ENST00000356562SERINC3chr20

43138532

-WFDC11chr20

44279290

-
5CDS-5UTRENST00000255175ENST00000324384SERINC3chr20

43138532

-WFDC11chr20

44279290

-
5CDS-5UTRENST00000342374ENST00000356562SERINC3chr20

43138532

-WFDC11chr20

44279290

-
5CDS-5UTRENST00000342374ENST00000324384SERINC3chr20

43138532

-WFDC11chr20

44279290

-
5CDS-5UTRENST00000541235ENST00000356562SERINC3chr20

43138532

-WFDC11chr20

44279290

-
5CDS-5UTRENST00000541235ENST00000324384SERINC3chr20

43138532

-WFDC11chr20

44279290

-
intron-5UTRENST00000468234ENST00000356562SERINC3chr20

43138532

-WFDC11chr20

44279290

-
intron-5UTRENST00000468234ENST00000324384SERINC3chr20

43138532

-WFDC11chr20

44279290

-

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FusionProtFeatures for SERINC3_WFDC11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERINC3

Q13530

WFDC11

Q8NEX6

Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734).{ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SERINC3_WFDC11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SERINC3_WFDC11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SERINC3XPO5, PHB2, SURF4, VDAC2, KDELR1, PTPLAD1, SLC16A1, KDELR2, ELAVL1, RPS15, BMP10WFDC11


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERINC3_WFDC11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERINC3_WFDC11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERINC3C0033578Prostatic Neoplasms1CTD_human