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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33255

FusionGeneSummary for SERINC3_SERINC3

check button Fusion gene summary
Fusion gene informationFusion gene name: SERINC3_SERINC3
Fusion gene ID: 33255
HgeneTgene
Gene symbol

SERINC3

SERINC3

Gene ID

10955

10955

Gene nameserine incorporator 3serine incorporator 3
SynonymsAIGP1|DIFF33|SBBI99|TDE|TDE1|TMS-1AIGP1|DIFF33|SBBI99|TDE|TDE1|TMS-1
Cytomap

20q13.12

20q13.12

Type of geneprotein-codingprotein-coding
Descriptionserine incorporator 3tumor differentially expressed protein 1serine incorporator 3tumor differentially expressed protein 1
Modification date2018052320180523
UniProtAcc

Q13530

Q13530

Ensembl transtripts involved in fusion geneENST00000255175, ENST00000342374, 
ENST00000541235, ENST00000468234, 
ENST00000255175, ENST00000342374, 
ENST00000541235, ENST00000468234, 
Fusion gene scores* DoF score5 X 5 X 4=1008 X 8 X 3=192
# samples 58
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SERINC3 [Title/Abstract] AND SERINC3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSERINC3

GO:0009597

detection of virus

26416733|26416734

HgeneSERINC3

GO:0045087

innate immune response

26416733|26416734

HgeneSERINC3

GO:0051607

defense response to virus

26416733|26416734

TgeneSERINC3

GO:0009597

detection of virus

26416733|26416734

TgeneSERINC3

GO:0045087

innate immune response

26416733|26416734

TgeneSERINC3

GO:0051607

defense response to virus

26416733|26416734


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CA842753SERINC3chr20

43129046

+SERINC3chr20

43133514

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000255175ENST00000255175SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000255175ENST00000342374SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000255175ENST00000541235SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-intronENST00000255175ENST00000468234SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000342374ENST00000255175SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000342374ENST00000342374SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000342374ENST00000541235SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-intronENST00000342374ENST00000468234SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000541235ENST00000255175SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000541235ENST00000342374SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000541235ENST00000541235SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-intronENST00000541235ENST00000468234SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000468234ENST00000255175SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000468234ENST00000342374SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-3CDSENST00000468234ENST00000541235SERINC3chr20

43129046

+SERINC3chr20

43133514

-
intron-intronENST00000468234ENST00000468234SERINC3chr20

43129046

+SERINC3chr20

43133514

-

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FusionProtFeatures for SERINC3_SERINC3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SERINC3

Q13530

SERINC3

Q13530

Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734).{ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}. Restriction factor required to restrict infectivity oflentiviruses, such as HIV-1: acts by inhibiting an early step ofviral infection. Impairs the penetration of the viral particleinto the cytoplasm (PubMed:26416733, PubMed:26416734).{ECO:0000269|PubMed:26416733, ECO:0000269|PubMed:26416734}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SERINC3_SERINC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SERINC3_SERINC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SERINC3_SERINC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SERINC3_SERINC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSERINC3C0033578Prostatic Neoplasms1CTD_human
TgeneSERINC3C0033578Prostatic Neoplasms1CTD_human