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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33224

FusionGeneSummary for SEPP1_C16orf45

check button Fusion gene summary
Fusion gene informationFusion gene name: SEPP1_C16orf45
Fusion gene ID: 33224
HgeneTgene
Gene symbol

SEPP1

C16orf45

Gene ID

89927

Gene namechromosome 16 open reading frame 45
SynonymsMINP
Cytomap

16p13.11

Type of geneprotein-coding
Descriptionuncharacterized protein C16orf45migration inhibitory protein
Modification date20180519
UniProtAcc

Q96MC5

Ensembl transtripts involved in fusion geneENST00000514985, ENST00000511224, 
ENST00000506577, ENST00000507920, 
ENST00000509276, 		ENST00000300006, 
ENST00000566490, ENST00000452191, 
ENST00000561692, ENST00000565913, 
Fusion gene scores* DoF score2 X 1 X 2=45 X 4 X 4=80
# samples 25
** MAII scorelog2(2/4*10)=2.32192809488736log2(5/80*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEPP1 [Title/Abstract] AND C16orf45 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLIHCTCGA-BC-A10X-01ASEPP1chr5

42799982

-C16orf45chr16

15675074

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000514985ENST00000300006SEPP1chr5

42799982

-C16orf45chr16

15675074

+
Frame-shiftENST00000514985ENST00000566490SEPP1chr5

42799982

-C16orf45chr16

15675074

+
Frame-shiftENST00000514985ENST00000452191SEPP1chr5

42799982

-C16orf45chr16

15675074

+
Frame-shiftENST00000514985ENST00000561692SEPP1chr5

42799982

-C16orf45chr16

15675074

+
5CDS-3UTRENST00000514985ENST00000565913SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000511224ENST00000300006SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000511224ENST00000566490SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000511224ENST00000452191SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000511224ENST00000561692SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3UTRENST00000511224ENST00000565913SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000506577ENST00000300006SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000506577ENST00000566490SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000506577ENST00000452191SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000506577ENST00000561692SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3UTRENST00000506577ENST00000565913SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000507920ENST00000300006SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000507920ENST00000566490SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000507920ENST00000452191SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000507920ENST00000561692SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3UTRENST00000507920ENST00000565913SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000509276ENST00000300006SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000509276ENST00000566490SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000509276ENST00000452191SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3CDSENST00000509276ENST00000561692SEPP1chr5

42799982

-C16orf45chr16

15675074

+
intron-3UTRENST00000509276ENST00000565913SEPP1chr5

42799982

-C16orf45chr16

15675074

+

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FusionProtFeatures for SEPP1_C16orf45


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEPP1

C16orf45

Q96MC5

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEPP1_C16orf45


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEPP1_C16orf45


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEPP1EGFR, THRA, MEOX2, EP300C16orf45ENO2, RAPGEF4, TCF12, BFSP1, CCDC101, ZYG11A, SPAG9, UBR3, POLE, ACTR10, POLE2, ACTR1B, ATE1, DCTN4, DCTN6, WDFY1, DCTN1, ACTR1A, TTC33, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEPP1_C16orf45


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEPP1_C16orf45


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource