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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3322

FusionGeneSummary for ATP1B3_GRK7

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP1B3_GRK7
Fusion gene ID: 3322
HgeneTgene
Gene symbol

ATP1B3

GRK7

Gene ID

483

131890

Gene nameATPase Na+/K+ transporting subunit beta 3G protein-coupled receptor kinase 7
SynonymsATPB-3|CD298GPRK7
Cytomap

3q23

3q23

Type of geneprotein-codingprotein-coding
Descriptionsodium/potassium-transporting ATPase subunit beta-3ATPase, Na+/K+ transporting, beta 3 polypeptideNa, K-ATPase beta-3 polypeptidesodium pump subunit beta-3sodium-potassium ATPase subunit beta 3 (non-catalytic)sodium/potassium-dependent ATPase subunitrhodopsin kinaseg protein-coupled receptor kinase GRK7
Modification date2018052320180519
UniProtAcc

P54709

Q8WTQ7

Ensembl transtripts involved in fusion geneENST00000286371, ENST00000539728, 
ENST00000462082, ENST00000484727, 
ENST00000264952, 
Fusion gene scores* DoF score2 X 2 X 1=41 X 3 X 1=3
# samples 43
** MAII scorelog2(4/4*10)=3.32192809488736log2(3/3*10)=3.32192809488736
Context

PubMed: ATP1B3 [Title/Abstract] AND GRK7 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotationKinase involved fusion gene, inframe and retained kinase domain.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneATP1B3

GO:0006883

cellular sodium ion homeostasis

10636900|19542013

HgeneATP1B3

GO:0010107

potassium ion import

10636900|19542013

HgeneATP1B3

GO:0030007

cellular potassium ion homeostasis

10636900|19542013

HgeneATP1B3

GO:0032781

positive regulation of ATPase activity

10636900

HgeneATP1B3

GO:0036376

sodium ion export across plasma membrane

10636900|19542013

HgeneATP1B3

GO:0050821

protein stabilization

10636900

HgeneATP1B3

GO:0072659

protein localization to plasma membrane

18522992

HgeneATP1B3

GO:0086009

membrane repolarization

19542013

HgeneATP1B3

GO:1901018

positive regulation of potassium ion transmembrane transporter activity

10636900

HgeneATP1B3

GO:1903278

positive regulation of sodium ion export across plasma membrane

10636900

HgeneATP1B3

GO:1903288

positive regulation of potassium ion import

10636900


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLUSCTCGA-33-AASJ-01AATP1B3chr3

141634862

+GRK7chr3

141535556

+
TCGALDLUSCTCGA-66-2771-01AATP1B3chr3

141595752

+GRK7chr3

141499216

+
TCGALDLUSCTCGA-66-2792-01AATP1B3chr3

141595752

+GRK7chr3

141526487

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000286371ENST00000264952ATP1B3chr3

141634862

+GRK7chr3

141535556

+
In-frameENST00000539728ENST00000264952ATP1B3chr3

141634862

+GRK7chr3

141535556

+
intron-3CDSENST00000462082ENST00000264952ATP1B3chr3

141634862

+GRK7chr3

141535556

+
intron-3CDSENST00000484727ENST00000264952ATP1B3chr3

141634862

+GRK7chr3

141535556

+
Frame-shiftENST00000286371ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141499216

+
5UTR-3CDSENST00000539728ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141499216

+
5UTR-3CDSENST00000462082ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141499216

+
intron-3CDSENST00000484727ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141499216

+
Frame-shiftENST00000286371ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141526487

+
5UTR-3CDSENST00000539728ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141526487

+
5UTR-3CDSENST00000462082ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141526487

+
intron-3CDSENST00000484727ENST00000264952ATP1B3chr3

141595752

+GRK7chr3

141526487

+

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FusionProtFeatures for ATP1B3_GRK7


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP1B3

P54709

GRK7

Q8WTQ7

This is the non-catalytic component of the activeenzyme, which catalyzes the hydrolysis of ATP coupled with theexchange of Na(+) and K(+) ions across the plasma membrane. Theexact function of the beta-3 subunit is not known. Retina-specific kinase involved in the shutoff of thephotoresponse and adaptation to changing light conditions via coneopsin phosphorylation, including rhodopsin (RHO).{ECO:0000269|PubMed:15946941}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1B3chr3:141634862chr3:141535556ENST00000286371+571_35194280Topological domainCytoplasmic
HgeneATP1B3chr3:141634862chr3:141535556ENST00000286371+5736_56194280TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGRK7chr3:141634862chr3:141535556ENST00000264952+24455_520441554DomainNote=AGC-kinase C-terminal

- In-frame and not-retained protein feature among the 13 regional features.
>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATP1B3chr3:141634862chr3:141535556ENST00000286371+57186_279194280Regionimmunoglobulin-like
HgeneATP1B3chr3:141634862chr3:141535556ENST00000286371+5757_279194280Topological domainExtracellular
TgeneGRK7chr3:141634862chr3:141535556ENST00000264952+24191_454441554DomainProtein kinase
TgeneGRK7chr3:141634862chr3:141535556ENST00000264952+2456_176441554DomainRGS
TgeneGRK7chr3:141634862chr3:141535556ENST00000264952+24197_205441554Nucleotide bindingATP


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FusionGeneSequence for ATP1B3_GRK7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP1B3_GRK7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP1B3PTP4A3, USP4, BARD1, BRCA1, PAXIP1, ADRB2, UPF2, KIAA0922, EMC1, ATP12A, TCTN2, HLA-C, PIGO, ALG9, KIAA2013, POMGNT2, MANEAL, REEP5, SCARB1, KIAA1715, TM9SF4, PCDH20, C4orf32, ABCA3, KIAA1467, TUBB8, HMGCR, TMEM259, FADS2, EFNB1, GLB1L2, ITGA7, RTN4, TM9SF2, PXYLP1, TMPPE, SEMA4C, ABHD3, POMT1, ARL6IP5, IMPAD1, GALNT7, SEMA4F, EMC7, RTN2, NRP2, BACE2, BTN2A2, TGFBR3, C10orf35, ITGB5, ACAA2, ACAT1, ANP32B, ATP1A1, ATP1A3, RPL26L1, ATP5F1, ATP6V0D1, ATP6V1E1, CPT2, CYB5B, CYC1, DLD, EEF2, HSD17B10, ITGA5, MTCH1, MTCH2, MYH2, NDUFA12, NDUFA2, NDUFA8, NDUFA9, NDUFB7, NDUFS1, NDUFS3, NDUFS5, OGDH, PSMD6, QARS, RAB1A, RAB1B, RPL10, RPL17, RPL22, RPL26, RPL35, RPLP2, RPS19, RPS8, RPS9, RTN3, TOMM40, UQCRB, VDAC1, VDAC2, VDAC3, EWSR1, GRN, TMX4, CGRRF1, TRIM25, BAALCGRK7NEDD4, HSP90AA1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP1B3_GRK7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP1B3_GRK7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource