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Fusion gene ID: 3322 |
FusionGeneSummary for ATP1B3_GRK7 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP1B3_GRK7 | Fusion gene ID: 3322 | Hgene | Tgene | Gene symbol | ATP1B3 | GRK7 | Gene ID | 483 | 131890 |
| Gene name | ATPase Na+/K+ transporting subunit beta 3 | G protein-coupled receptor kinase 7 | |
| Synonyms | ATPB-3|CD298 | GPRK7 | |
| Cytomap | 3q23 | 3q23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/potassium-transporting ATPase subunit beta-3ATPase, Na+/K+ transporting, beta 3 polypeptideNa, K-ATPase beta-3 polypeptidesodium pump subunit beta-3sodium-potassium ATPase subunit beta 3 (non-catalytic)sodium/potassium-dependent ATPase subunit | rhodopsin kinaseg protein-coupled receptor kinase GRK7 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P54709 | Q8WTQ7 | |
| Ensembl transtripts involved in fusion gene | ENST00000286371, ENST00000539728, ENST00000462082, ENST00000484727, | ENST00000264952, | |
| Fusion gene scores | * DoF score | 2 X 2 X 1=4 | 1 X 3 X 1=3 |
| # samples | 4 | 3 | |
| ** MAII score | log2(4/4*10)=3.32192809488736 | log2(3/3*10)=3.32192809488736 | |
| Context | PubMed: ATP1B3 [Title/Abstract] AND GRK7 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | Kinase involved fusion gene, inframe and retained kinase domain. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP1B3 | GO:0006883 | cellular sodium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0010107 | potassium ion import | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0030007 | cellular potassium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0032781 | positive regulation of ATPase activity | 10636900 |
| Hgene | ATP1B3 | GO:0036376 | sodium ion export across plasma membrane | 10636900|19542013 |
| Hgene | ATP1B3 | GO:0050821 | protein stabilization | 10636900 |
| Hgene | ATP1B3 | GO:0072659 | protein localization to plasma membrane | 18522992 |
| Hgene | ATP1B3 | GO:0086009 | membrane repolarization | 19542013 |
| Hgene | ATP1B3 | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 10636900 |
| Hgene | ATP1B3 | GO:1903278 | positive regulation of sodium ion export across plasma membrane | 10636900 |
| Hgene | ATP1B3 | GO:1903288 | positive regulation of potassium ion import | 10636900 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUSC | TCGA-33-AASJ-01A | ATP1B3 | chr3 | 141634862 | + | GRK7 | chr3 | 141535556 | + |
| TCGA | LD | LUSC | TCGA-66-2771-01A | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141499216 | + |
| TCGA | LD | LUSC | TCGA-66-2792-01A | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141526487 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000286371 | ENST00000264952 | ATP1B3 | chr3 | 141634862 | + | GRK7 | chr3 | 141535556 | + |
| In-frame | ENST00000539728 | ENST00000264952 | ATP1B3 | chr3 | 141634862 | + | GRK7 | chr3 | 141535556 | + |
| intron-3CDS | ENST00000462082 | ENST00000264952 | ATP1B3 | chr3 | 141634862 | + | GRK7 | chr3 | 141535556 | + |
| intron-3CDS | ENST00000484727 | ENST00000264952 | ATP1B3 | chr3 | 141634862 | + | GRK7 | chr3 | 141535556 | + |
| Frame-shift | ENST00000286371 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141499216 | + |
| 5UTR-3CDS | ENST00000539728 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141499216 | + |
| 5UTR-3CDS | ENST00000462082 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141499216 | + |
| intron-3CDS | ENST00000484727 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141499216 | + |
| Frame-shift | ENST00000286371 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141526487 | + |
| 5UTR-3CDS | ENST00000539728 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141526487 | + |
| 5UTR-3CDS | ENST00000462082 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141526487 | + |
| intron-3CDS | ENST00000484727 | ENST00000264952 | ATP1B3 | chr3 | 141595752 | + | GRK7 | chr3 | 141526487 | + |
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FusionProtFeatures for ATP1B3_GRK7 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP1B3 | GRK7 |
| This is the non-catalytic component of the activeenzyme, which catalyzes the hydrolysis of ATP coupled with theexchange of Na(+) and K(+) ions across the plasma membrane. Theexact function of the beta-3 subunit is not known. | Retina-specific kinase involved in the shutoff of thephotoresponse and adaptation to changing light conditions via coneopsin phosphorylation, including rhodopsin (RHO).{ECO:0000269|PubMed:15946941}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATP1B3 | chr3:141634862 | chr3:141535556 | ENST00000286371 | + | 5 | 7 | 1_35 | 194 | 280 | Topological domain | Cytoplasmic |
| Hgene | ATP1B3 | chr3:141634862 | chr3:141535556 | ENST00000286371 | + | 5 | 7 | 36_56 | 194 | 280 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | >GRK7 | chr3:141634862 | chr3:141535556 | ENST00000264952 | + | 2 | 4 | 455_520 | 441 | 554 | Domain | Note=AGC-kinase C-terminal |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ATP1B3 | chr3:141634862 | chr3:141535556 | ENST00000286371 | + | 5 | 7 | 186_279 | 194 | 280 | Region | immunoglobulin-like |
| Hgene | >ATP1B3 | chr3:141634862 | chr3:141535556 | ENST00000286371 | + | 5 | 7 | 57_279 | 194 | 280 | Topological domain | Extracellular |
| Tgene | GRK7 | chr3:141634862 | chr3:141535556 | ENST00000264952 | + | 2 | 4 | 191_454 | 441 | 554 | Domain | Protein kinase |
| Tgene | GRK7 | chr3:141634862 | chr3:141535556 | ENST00000264952 | + | 2 | 4 | 56_176 | 441 | 554 | Domain | RGS |
| Tgene | GRK7 | chr3:141634862 | chr3:141535556 | ENST00000264952 | + | 2 | 4 | 197_205 | 441 | 554 | Nucleotide binding | ATP |
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FusionGeneSequence for ATP1B3_GRK7 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP1B3_GRK7 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP1B3 | PTP4A3, USP4, BARD1, BRCA1, PAXIP1, ADRB2, UPF2, KIAA0922, EMC1, ATP12A, TCTN2, HLA-C, PIGO, ALG9, KIAA2013, POMGNT2, MANEAL, REEP5, SCARB1, KIAA1715, TM9SF4, PCDH20, C4orf32, ABCA3, KIAA1467, TUBB8, HMGCR, TMEM259, FADS2, EFNB1, GLB1L2, ITGA7, RTN4, TM9SF2, PXYLP1, TMPPE, SEMA4C, ABHD3, POMT1, ARL6IP5, IMPAD1, GALNT7, SEMA4F, EMC7, RTN2, NRP2, BACE2, BTN2A2, TGFBR3, C10orf35, ITGB5, ACAA2, ACAT1, ANP32B, ATP1A1, ATP1A3, RPL26L1, ATP5F1, ATP6V0D1, ATP6V1E1, CPT2, CYB5B, CYC1, DLD, EEF2, HSD17B10, ITGA5, MTCH1, MTCH2, MYH2, NDUFA12, NDUFA2, NDUFA8, NDUFA9, NDUFB7, NDUFS1, NDUFS3, NDUFS5, OGDH, PSMD6, QARS, RAB1A, RAB1B, RPL10, RPL17, RPL22, RPL26, RPL35, RPLP2, RPS19, RPS8, RPS9, RTN3, TOMM40, UQCRB, VDAC1, VDAC2, VDAC3, EWSR1, GRN, TMX4, CGRRF1, TRIM25, BAALC | GRK7 | NEDD4, HSP90AA1 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP1B3_GRK7 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP1B3_GRK7 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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