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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33214

FusionGeneSummary for SENP6_OOEP

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP6_OOEP
Fusion gene ID: 33214
HgeneTgene
Gene symbol

SENP6

OOEP

Gene ID

26054

441161

Gene nameSUMO specific peptidase 6oocyte expressed protein
SynonymsSSP1|SUSP1C6orf156|FLOPED|HOEP19|KHDC2
Cytomap

6q14.1

6q13

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 62810017C20RikSUMO-1-specific protease 1SUMO1/sentrin specific peptidase 6SUMO1/sentrin specific protease 6sentrin/SUMO-specific protease SENP6oocyte-expressed protein homologKH homology domain containing 2KH homology domain-containing protein 2oocyte and embryo protein 19oocyte expressed protein homolog (dog)oocyte- and embryo-specific protein 19
Modification date2018052320180329
UniProtAcc

Q9GZR1

A6NGQ2

Ensembl transtripts involved in fusion geneENST00000370010, ENST00000370014, 
ENST00000447266, ENST00000541192, 
ENST00000327284, ENST00000436928, 
ENST00000370363, ENST00000370359, 
Fusion gene scores* DoF score9 X 9 X 6=4865 X 2 X 3=30
# samples 95
** MAII scorelog2(9/486*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(5/30*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SENP6 [Title/Abstract] AND OOEP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP6

GO:0070646

protein modification by small protein removal

20212317


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-HC-7210-01ASENP6chr6

76344527

+OOEPchr6

74079108

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000370010ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000370010ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000370014ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000370014ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000447266ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000447266ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-
intron-3CDSENST00000541192ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
intron-3CDSENST00000541192ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000327284ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
Frame-shitENST00000327284ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-
intron-3CDSENST00000436928ENST00000370363SENP6chr6

76344527

+OOEPchr6

74079108

-
intron-3CDSENST00000436928ENST00000370359SENP6chr6

76344527

+OOEPchr6

74079108

-

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FusionProtFeatures for SENP6_OOEP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP6

Q9GZR1

OOEP

A6NGQ2

Protease that deconjugates SUMO1, SUMO2 and SUMO3 fromtargeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 andSUMO3 precursors. Deconjugates SUMO1 from RXRA, leading totranscriptional activation. Involved in chromosome alignment andspindle assembly, by regulating the kinetochore CENPH-CENPI-CENPKcomplex. Desumoylates PML and CENPI, protecting them fromdegradation by the ubiquitin ligase RNF4, which targetspolysumoylated proteins for proteasomal degradation. Desumoylatesalso RPA1, thus preventing recruitment of RAD51 to the DNA damagefoci to initiate DNA repair through homologous recombination.{ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875,ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. As a member of the subcortical maternal complex (SCMC),plays an essential role for zygotes to progress beyond the firstembryonic cell divisions. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SENP6_OOEP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SENP6_OOEP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SENP6RUVBL2, KAT5, SUMO2, COPS5, LMNA, SP1, SUMO1, PLA2G2A, FHL3, EXO1, PRPF19, ZDBF2OOEP


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SENP6_OOEP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SENP6_OOEP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource