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Fusion gene ID: 33212 |
FusionGeneSummary for SENP6_GPR124 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SENP6_GPR124 | Fusion gene ID: 33212 | Hgene | Tgene | Gene symbol | SENP6 | GPR124 | Gene ID | 26054 | 25960 |
| Gene name | SUMO specific peptidase 6 | adhesion G protein-coupled receptor A2 | |
| Synonyms | SSP1|SUSP1 | GPR124|TEM5 | |
| Cytomap | 6q14.1 | 8p11.23 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sentrin-specific protease 62810017C20RikSUMO-1-specific protease 1SUMO1/sentrin specific peptidase 6SUMO1/sentrin specific protease 6sentrin/SUMO-specific protease SENP6 | adhesion G protein-coupled receptor A2G-protein coupled receptor 124tumor endothelial marker 5 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9GZR1 | ||
| Ensembl transtripts involved in fusion gene | ENST00000370010, ENST00000370014, ENST00000447266, ENST00000541192, ENST00000327284, ENST00000436928, | ENST00000315215, ENST00000412232, | |
| Fusion gene scores | * DoF score | 9 X 9 X 6=486 | 1 X 1 X 1=1 |
| # samples | 9 | 1 | |
| ** MAII score | log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(1/1*10)=3.32192809488736 | |
| Context | PubMed: SENP6 [Title/Abstract] AND GPR124 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SENP6 | GO:0070646 | protein modification by small protein removal | 20212317 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | BRCA | TCGA-D8-A27R-01A | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000370010 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000370010 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000370014 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000370014 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000447266 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000447266 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| intron-3CDS | ENST00000541192 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| intron-3CDS | ENST00000541192 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000327284 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| Frame-shift | ENST00000327284 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| intron-3CDS | ENST00000436928 | ENST00000315215 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
| intron-3CDS | ENST00000436928 | ENST00000412232 | SENP6 | chr6 | 76373234 | + | GPR124 | chr8 | 37672414 | + |
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FusionProtFeatures for SENP6_GPR124 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SENP6 | GPR124 |
| Protease that deconjugates SUMO1, SUMO2 and SUMO3 fromtargeted proteins. Processes preferentially poly-SUMO2 and poly-SUMO3 chains, but does not efficiently process SUMO1, SUMO2 andSUMO3 precursors. Deconjugates SUMO1 from RXRA, leading totranscriptional activation. Involved in chromosome alignment andspindle assembly, by regulating the kinetochore CENPH-CENPI-CENPKcomplex. Desumoylates PML and CENPI, protecting them fromdegradation by the ubiquitin ligase RNF4, which targetspolysumoylated proteins for proteasomal degradation. Desumoylatesalso RPA1, thus preventing recruitment of RAD51 to the DNA damagefoci to initiate DNA repair through homologous recombination.{ECO:0000269|PubMed:16912044, ECO:0000269|PubMed:17000875,ECO:0000269|PubMed:18799455, ECO:0000269|PubMed:20212317,ECO:0000269|PubMed:20705237, ECO:0000269|PubMed:21148299}. | Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SENP6_GPR124 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SENP6_GPR124 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SENP6 | RUVBL2, KAT5, SUMO2, COPS5, LMNA, SP1, SUMO1, PLA2G2A, FHL3, EXO1, PRPF19, ZDBF2 | GPR124 | DLG1, RYK |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SENP6_GPR124 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SENP6_GPR124 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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