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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33208

FusionGeneSummary for SENP5_TCTEX1D2

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP5_TCTEX1D2
Fusion gene ID: 33208
HgeneTgene
Gene symbol

SENP5

TCTEX1D2

Gene ID

205564

255758

Gene nameSUMO specific peptidase 5Tctex1 domain containing 2
Synonyms-SRTD17
Cytomap

3q29

3q29

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5tctex1 domain-containing protein 2
Modification date2018052320180519
UniProtAcc

Q96HI0

Q8WW35

Ensembl transtripts involved in fusion geneENST00000445299, ENST00000323460, 
ENST00000419026, ENST00000489744, 
ENST00000491186, ENST00000325318, 
Fusion gene scores* DoF score8 X 6 X 7=3367 X 5 X 6=210
# samples 99
** MAII scorelog2(9/336*10)=-1.90046432644909
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(9/210*10)=-1.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SENP5 [Title/Abstract] AND TCTEX1D2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-78-7147-01ASENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-intronENST00000445299ENST00000491186SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
5UTR-intronENST00000445299ENST00000325318SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
5UTR-intronENST00000323460ENST00000491186SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
5UTR-intronENST00000323460ENST00000325318SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
5UTR-intronENST00000419026ENST00000491186SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
5UTR-intronENST00000419026ENST00000325318SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
intron-intronENST00000489744ENST00000491186SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-
intron-intronENST00000489744ENST00000325318SENP5chr3

196594944

+TCTEX1D2chr3

196033883

-

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FusionProtFeatures for SENP5_TCTEX1D2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP5

Q96HI0

TCTEX1D2

Q8WW35

Protease that catalyzes two essential functions in theSUMO pathway: processing of full-length SUMO3 to its mature formand deconjugation of SUMO2 and SUMO3 from targeted proteins. Hasweak proteolytic activity against full-length SUMO1 or SUMO1conjugates. Required for cell division.{ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. Required for proper retrograde ciliary transport.{ECO:0000269|PubMed:26044572}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SENP5_TCTEX1D2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SENP5_TCTEX1D2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SENP5PASK, SUMO3, SUMO2, RABGAP1, ASGR2, NPM1, ZCCHC7, SKAP1, CASQ2, C1orf186, ZNF131, CAMK2D, DKK3, SSSCA1, MIS18A, MAPK8IP1, LOXL3TCTEX1D2PPP2CB, CSNK2B, TK1, BRCA1, GTF2F2, ABHD17A, DYNLT1, WDR60, COMMD10, WDR34, VWA2, DEFB121, ABHD17B, CLMN, ABTB2, SNX6, SNX2, DYNLT3, DYNLRB1, TIPRL, PAFAH1B1, DYNLRB2, MAPRE2, DYNLL1, VIM


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SENP5_TCTEX1D2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SENP5_TCTEX1D2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource