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Fusion gene ID: 33202 |
FusionGeneSummary for SENP5_KCNMB3 |
Fusion gene summary |
Fusion gene information | Fusion gene name: SENP5_KCNMB3 | Fusion gene ID: 33202 | Hgene | Tgene | Gene symbol | SENP5 | KCNMB3 | Gene ID | 205564 | 27094 |
Gene name | SUMO specific peptidase 5 | potassium calcium-activated channel subfamily M regulatory beta subunit 3 | |
Synonyms | - | BKBETA3|HBETA3|K(VCA)BETA-3|KCNMB2|KCNMBL|SLO-BETA-3|SLOBETA3 | |
Cytomap | 3q29 | 3q26.32 | |
Type of gene | protein-coding | protein-coding | |
Description | sentrin-specific protease 5SUMO1/sentrin specific peptidase 5SUMO1/sentrin specific protease 5sentrin/SUMO-specific protease SENP5 | calcium-activated potassium channel subunit beta-3BK channel beta subunit 3BK channel subunit beta-3MaxiK channel beta-subunit 3big potassium channel beta subunit 3calcium-activated potassium channel regulatory subunitcalcium-activated potassium cha | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q96HI0 | Q9NPA1 | |
Ensembl transtripts involved in fusion gene | ENST00000445299, ENST00000323460, ENST00000419026, ENST00000489744, | ENST00000486944, ENST00000497599, ENST00000392685, ENST00000314235, ENST00000349697, ENST00000485523, | |
Fusion gene scores | * DoF score | 8 X 6 X 7=336 | 2 X 2 X 2=8 |
# samples | 9 | 2 | |
** MAII score | log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
Context | PubMed: SENP5 [Title/Abstract] AND KCNMB3 [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | KCNMB3 | GO:0001508 | action potential | 10692449 |
Tgene | KCNMB3 | GO:0005513 | detection of calcium ion | 10692449 |
Tgene | KCNMB3 | GO:0006813 | potassium ion transport | 10692449 |
Tgene | KCNMB3 | GO:0019228 | neuronal action potential | 10692449 |
Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | HNSC | TCGA-TN-A7HJ-01A | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000445299 | ENST00000486944 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000445299 | ENST00000497599 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000445299 | ENST00000392685 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000445299 | ENST00000314235 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000445299 | ENST00000349697 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000445299 | ENST00000485523 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000486944 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000497599 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000392685 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000314235 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000349697 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000323460 | ENST00000485523 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000486944 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000497599 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000392685 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000314235 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000349697 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
5CDS-intron | ENST00000419026 | ENST00000485523 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000486944 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000497599 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000392685 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000314235 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000349697 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
intron-intron | ENST00000489744 | ENST00000485523 | SENP5 | chr3 | 196657771 | + | KCNMB3 | chr3 | 178962481 | - |
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FusionProtFeatures for SENP5_KCNMB3 |
Main function of each fusion partner protein. (from UniProt) |
Hgene | Tgene |
SENP5 | KCNMB3 |
Protease that catalyzes two essential functions in theSUMO pathway: processing of full-length SUMO3 to its mature formand deconjugation of SUMO2 and SUMO3 from targeted proteins. Hasweak proteolytic activity against full-length SUMO1 or SUMO1conjugates. Required for cell division.{ECO:0000269|PubMed:16608850, ECO:0000269|PubMed:16738315}. | Regulatory subunit of the calcium activated potassiumKCNMA1 (maxiK) channel. Modulates the calcium sensitivity andgating kinetics of KCNMA1, thereby contributing to KCNMA1 channeldiversity. Alters the functional properties of the currentexpressed by the KCNMA1 channel. Isoform 2, isoform 3 and isoform4 partially inactivate the current of KCNBMA. Isoform 4 induces afast and incomplete inactivation of KCNMA1 channel that isdetectable only at large depolarizations. In contrast, isoform 1does not induce detectable inactivation of KCNMA1. Two or moresubunits of KCNMB3 are required to block the KCNMA1 tetramer.{ECO:0000269|PubMed:10766764, ECO:0000269|PubMed:10864947}. |
Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SENP5_KCNMB3 |
For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SENP5_KCNMB3 |
Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SENP5 | PASK, SUMO3, SUMO2, RABGAP1, ASGR2, NPM1, ZCCHC7, SKAP1, CASQ2, C1orf186, ZNF131, CAMK2D, DKK3, SSSCA1, MIS18A, MAPK8IP1, LOXL3 | KCNMB3 |
- Retained PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
- Lost PPIs in in-frame fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
- Retained PPIs, but lost function due to frame-shift fusion. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SENP5_KCNMB3 |
Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | KCNMB3 | Q9NPA1 | DB01110 | Miconazole | Calcium-activated potassium channel subunit beta-3 | small molecule | approved|investigational|vet_approved |
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RelatedDiseases for SENP5_KCNMB3 |
Diseases associated with fusion partners. (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |