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Fusion gene ID: 3320 |
FusionGeneSummary for ATP1B2_SLC37A3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP1B2_SLC37A3 | Fusion gene ID: 3320 | Hgene | Tgene | Gene symbol | ATP1B2 | SLC37A3 | Gene ID | 482 | 84255 |
| Gene name | ATPase Na+/K+ transporting subunit beta 2 | solute carrier family 37 member 3 | |
| Synonyms | AMOG | - | |
| Cytomap | 17p13.1 | 7q34 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/potassium-transporting ATPase subunit beta-2ATPase, Na+/K+ transporting, beta 2 polypeptideNa, K-ATPase beta-2 polypeptideadhesion molecule in gliaadhesion molecule on gliasodium pump subunit beta-2sodium-potassium ATPase subunit beta 2 (non- | sugar phosphate exchanger 3solute carrier family 37 (glycerol-3-phosphate transporter), member 3 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P14415 | Q8NCC5 | |
| Ensembl transtripts involved in fusion gene | ENST00000250111, | ENST00000340308, ENST00000447932, ENST00000326232, ENST00000429996, ENST00000461089, | |
| Fusion gene scores | * DoF score | 3 X 3 X 2=18 | 4 X 3 X 4=48 |
| # samples | 3 | 4 | |
| ** MAII score | log2(3/18*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: ATP1B2 [Title/Abstract] AND SLC37A3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP1B2 | GO:0006883 | cellular sodium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0010107 | potassium ion import | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0030007 | cellular potassium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0032781 | positive regulation of ATPase activity | 10636900 |
| Hgene | ATP1B2 | GO:0036376 | sodium ion export across plasma membrane | 10636900|19542013 |
| Hgene | ATP1B2 | GO:0050821 | protein stabilization | 10636900 |
| Hgene | ATP1B2 | GO:0086009 | membrane repolarization | 19542013 |
| Hgene | ATP1B2 | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 10636900 |
| Hgene | ATP1B2 | GO:1903278 | positive regulation of sodium ion export across plasma membrane | 10636900 |
| Hgene | ATP1B2 | GO:1903288 | positive regulation of potassium ion import | 10636900 |
| Tgene | SLC37A3 | GO:0015760 | glucose-6-phosphate transport | 21949678 |
| Tgene | SLC37A3 | GO:0035435 | phosphate ion transmembrane transport | 21949678 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A8BM-01A | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000250111 | ENST00000340308 | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
| Frame-shift | ENST00000250111 | ENST00000447932 | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
| Frame-shift | ENST00000250111 | ENST00000326232 | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
| 5CDS-intron | ENST00000250111 | ENST00000429996 | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
| 5CDS-intron | ENST00000250111 | ENST00000461089 | ATP1B2 | chr17 | 7554948 | + | SLC37A3 | chr7 | 140037149 | - |
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FusionProtFeatures for ATP1B2_SLC37A3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP1B2 | SLC37A3 |
| This is the non-catalytic component of the activeenzyme, which catalyzes the hydrolysis of ATP coupled with theexchange of Na(+) and K(+) ions across the plasma membrane. Theexact function of the beta-2 subunit is not known. Mediates cell adhesion of neurons and astrocytes, andpromotes neurite outgrowth. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ATP1B2 | chr17:7554948 | chr7:140037149 | ENST00000250111 | + | 1 | 7 | 1_39 | 37 | 291 | Topological domain | Cytoplasmic |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 452_472 | 442 | 495 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 357_377 | 341 | 444 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 386_406 | 341 | 444 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 428_448 | 341 | 444 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 452_472 | 341 | 444 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 428_448 | 426 | 479 | Transmembrane | Helical |
| Tgene | >SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 452_472 | 426 | 479 | Transmembrane | Helical |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >ATP1B2 | chr17:7554948 | chr7:140037149 | ENST00000250111 | + | 1 | 7 | 193_290 | 37 | 291 | Region | Note=immunoglobulin-like |
| Hgene | >ATP1B2 | chr17:7554948 | chr7:140037149 | ENST00000250111 | + | 1 | 7 | 68_290 | 37 | 291 | Topological domain | Extracellular |
| Hgene | >ATP1B2 | chr17:7554948 | chr7:140037149 | ENST00000250111 | + | 1 | 7 | 40_67 | 37 | 291 | Transmembrane | Helical%3B Signal-anchor for type II membrane protein |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 113_133 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 147_167 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 16_36 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 177_197 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 209_229 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 297_317 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 333_353 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 357_377 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 386_406 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 428_448 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000326232 | - | 12 | 15 | 81_101 | 442 | 495 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 113_133 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 147_167 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 16_36 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 177_197 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 209_229 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 297_317 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 333_353 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000340308 | - | 9 | 12 | 81_101 | 341 | 444 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 113_133 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 147_167 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 16_36 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 177_197 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 209_229 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 297_317 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 333_353 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 357_377 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 386_406 | 426 | 479 | Transmembrane | Helical |
| Tgene | SLC37A3 | chr17:7554948 | chr7:140037149 | ENST00000447932 | - | 11 | 14 | 81_101 | 426 | 479 | Transmembrane | Helical |
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FusionGeneSequence for ATP1B2_SLC37A3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_ATP1B2_ENST00000250111_chr17_7554948_+_SLC37A3_ENST00000340308_chr7_140037149_-_140aa MVIQKEKKSCGQVVEEWKEFVWNPRTHQFMGRTGTSWVFSVSDPGQARMDVGFLLFHSHDKLYNCVYLAINSEGNILSRAKETGSHIEGV |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_ATP1B2_ENST00000250111_chr17_7554948_+_SLC37A3_ENST00000340308_chr7_140037149_-_420nt ATGGTCATCCAGAAAGAGAAGAAGAGCTGCGGGCAGGTGGTTGAGGAGTGGAAGGAGTTCGTGTGGAACCCGAGGACGCACCAGTTTATG GGCCGCACCGGGACCAGCTGGGTATTTAGTGTCTCTGATCCGGGACAAGCTAGGATGGATGTGGGTTTTCTACTTTTTCATTCTCATGAC AAGTTGTACAATTGTGTTTATCTCGCCATTAATAGTGAGGGAAATATTCTCTCTCGTGCTAAGGAGACAGGCTCACATATTGAGGGAGTG ACCGGTGCCCGCGAGACAGAAAGAACAATGTCAGCCACATCAGGACCGCTGGGGCTTCGAGTCTGCCCTAATTTGGGTTTGTCTAGGAGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_ATP1B2_ENST00000250111_chr17_7554948_+_SLC37A3_ENST00000340308_chr7_140037149_-_2338nt CCACCTCTCTCTGCCTTTTTGTACCCCGCTTTTTTTCTGCGTTCTGCTCGGTTTTTGTAGCCGTCTGTTTTTGCACCCCATTTCGTTTTG TTTCTAGACGGTTTGGTGGGGGGTGAAGCTGCATTCATACCCCTTCCTCTTGTTATTCTCCCCTGCTCTGACAGCACCCCTTTTCATCGC AGTTGGGGGGCCTAGGATCGGTGCATCTTCCGCCGCGCTGCCAGCACCCCGCAGCGCGTGGTCGTGCACCCCGGAATCTGCAGCAGCTGC ATATCTGAGGGGGGTCTCCTTTGCCCGCGCCGCCTTCGCTCCCCGTGCTTTTGGGTGTGTGGAGGGCTTCAGCGCGCGGCGCCCCCGCTT CTCCGCAACCCCCCGCCCCGCGCCCGGACTCGCCCCGCGCCACCAAGATGGTCATCCAGAAAGAGAAGAAGAGCTGCGGGCAGGTGGTTG AGGAGTGGAAGGAGTTCGTGTGGAACCCGAGGACGCACCAGTTTATGGGCCGCACCGGGACCAGCTGGGTATTTAGTGTCTCTGATCCGG GACAAGCTAGGATGGATGTGGGTTTTCTACTTTTTCATTCTCATGACAAGTTGTACAATTGTGTTTATCTCGCCATTAATAGTGAGGGAA ATATTCTCTCTCGTGCTAAGGAGACAGGCTCACATATTGAGGGAGTGACCGGTGCCCGCGAGACAGAAAGAACAATGTCAGCCACATCAG GACCGCTGGGGCTTCGAGTCTGCCCTAATTTGGGTTTGTCTAGGAGCTCCAGCCTGATCTTGGATTGTCAGGCGTCTCTCAACACTGCCA GCCACCTGAGATGCTGACCAGCAGTGAAGGCTGCACTAGTTTTCTACACTACAGGAATTACTGTTGATGATTTTTGCTGTTGTTTCATGA ATGTGCCGAGTGACTTCTGACTCTGCCAGCATCTTTGACCTCTGACTCTGCCCGCGTCTTTGTTTGGCCTATTGAGGTTTAGCGTTTTAA CCTTAACTGTTGTTTTGGACTTGAACTTTCTCTAGCCTTGAAAATGGAGTGAACAGGAGGCAAAGCCACGCGTGGTTTGTGTTGGTGGTA TGTTCCACAAATGGAAGAGATCATTGCATTTTGCTTTGGTAATGAGTTTACAGAGAGTGGGTCATCTTTGAAGCATCAAATCCTGATCAA ATGCTCAAGCTGGACCGAGCTGCAAGCCTGCCTTGGACAAAGAATCCCTCTGTTCACTGTGGTGGGAAAGATCACACTACATGCCTGTTG ATTGGCTCAGTCACTCTGTGTCTGATCTAAACGTCATTCAGCCCTAGAAGCATGAATTGCTTCAAATTATTGTCAACTTGTTCTCTTCCA TTTTCATTCAAATTAACTTTGACTCCTGGAAGTATTGAGTCTTCCTTTCAAGGACCATAAGGTACATCAGTTATCTTGAACATTCTGACG TGTAAAGGACCATAAGGTACATCATTTATCTTGAACATTCCGACGTGTAACTCACAGCCGAAGCACTCCATCCCAGATTTGTTGTCTGGG AACTTAGGATCCTCTAGGAAGCTAATCTGCTTAGTCTATTTTTAGAGGATTGATCTCTGGCACAAGCAGCTTCCTGGAGTTACCTCAGCA GAAGACTAGAATTAGAGAAAAGGGAAAGACCTTTTCTTCTAGTAAGTGTCAAGTACAGATGCTCTTTGACTTATGATGGGGTTATGTCCC AGTAAACCCATTGGAAGTCAAATGCATTTAATACCCCTGACTGGACACCACAGCTTAGCCTCGTCCACCCTAAATGTACTCAGAACACTT AGAATTGCCCACAGTTGGGCAGAATCATCTAACACAAACTCTATTTTATAATCGAGTGTTGAATATATCATGTAATTTATTGAATATTGT ACATTATGTTGAAATTGCAACCATTTCACACCATTGTAAAGTCCAAAAATCAGAAGCTGAGGACTGTCTGTACATGACATTGAATCACAT GAATGGATTACTAGGGCCTGAGGGGTGTCCGTTCTTTAGAAAAATGTAGAGTATATATATCTTCAGGGCTGTGAATTCCATACTAGTTAT CAATATTTTAAGATCATTCTGTATATACATATTTTAAATTATGCAAGCAAACTAGGAGGAGAATGTGCAATTTTGAGGGATACCTAATTT GCATTCGGTTAGGGGATATTTTTCAACCTCTTGCTTTATACTCTGATATGGGGTGTGTTTATGAACTTGTTAATGTTATTTAATCATGCA |
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FusionGenePPI for ATP1B2_SLC37A3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP1B2 | COPG2, ATP1A1, ATP5F1, RPL26, RPLP2, RPS18, RPS8, RTN4 | SLC37A3 | FOXJ1, ZNF177, SPRYD7, ATRAID, CAV1, CLTCL1, APOB, SLC25A46, MTX3, RNASEL, TUBGCP2, ATP12A, CYB5R3, DNAJC19, ARL15, SLC25A30, SLC5A3, NR2F2, DAAM1, HSD17B7, CSNK1G3, NRAS |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP1B2_SLC37A3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP1B2_SLC37A3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATP1B2 | C0017638 | Glioma | 1 | CTD_human |
| Hgene | ATP1B2 | C0279626 | Squamous cell carcinoma of esophagus | 1 | CTD_human |
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