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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33197

FusionGeneSummary for SENP3_ARHGAP27

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP3_ARHGAP27
Fusion gene ID: 33197
HgeneTgene
Gene symbol

SENP3

ARHGAP27

Gene ID

26168

201176

Gene nameSUMO specific peptidase 3Rho GTPase activating protein 27
SynonymsSMT3IP1|SSP3|Ulp1CAMGAP1|PP905|SH3D20|SH3P20
Cytomap

17p13.1

17q21.31

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 3SUMO-1-specific protease 3SUMO1/sentrin/SMT3 specific peptidase 3sentrin/SUMO-specific protease 3rho GTPase-activating protein 27CIN85-associated multi-domain-containing Rho GTPase-activating protein 1SH3 domain containing 20SH3 domain-containing protein 20rho-type GTPase-activating protein 27
Modification date2018052320180523
UniProtAcc

Q9H4L4

Q6ZUM4

Ensembl transtripts involved in fusion geneENST00000578868, ENST00000321337, 
ENST00000429205, 		ENST00000532038, 
ENST00000376922, ENST00000528384, 
ENST00000455881, ENST00000532891, 
ENST00000428638, ENST00000442348, 
ENST00000582826, ENST00000528273, 
ENST00000290470, 
Fusion gene scores* DoF score6 X 5 X 5=1503 X 3 X 2=18
# samples 62
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/18*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SENP3 [Title/Abstract] AND ARHGAP27 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDSARCTCGA-DX-A6YQ-01ASENP3chr17

7474967

+ARHGAP27chr17

43472567

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000578868ENST00000532038SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000578868ENST00000376922SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000578868ENST00000528384SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000455881SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000532891SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000428638SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000442348SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000582826SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000528273SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000578868ENST00000290470SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000321337ENST00000532038SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000321337ENST00000376922SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000321337ENST00000528384SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000455881SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000532891SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000428638SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000442348SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000582826SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000528273SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000321337ENST00000290470SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000429205ENST00000532038SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000429205ENST00000376922SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-3UTRENST00000429205ENST00000528384SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000455881SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000532891SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000428638SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000442348SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000582826SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000528273SENP3chr17

7474967

+ARHGAP27chr17

43472567

-
3UTR-intronENST00000429205ENST00000290470SENP3chr17

7474967

+ARHGAP27chr17

43472567

-

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FusionProtFeatures for SENP3_ARHGAP27


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP3

Q9H4L4

ARHGAP27

Q6ZUM4

Protease that releases SUMO2 and SUMO3 monomers fromsumoylated substrates, but has only weak activity against SUMO1conjugates. Deconjugates SUMO2 from MEF2D, which increases itstranscriptional activation capability. Deconjugates SUMO2 andSUMO3 from CDCA8. Redox sensor that, when redistributed intonucleoplasm, can act as an effector to enhance HIF1Atranscriptional activity by desumoylating EP300. Required for rRNAprocessing through deconjugation of SUMO2 and SUMO3 fromnucleophosmin, NPM1. Plays a role in the regulation of sumoylationstatus of ZNF148. Functions as a component of the Five Friends ofMethylated CHTOP (5FMC) complex; the 5FMC complex is recruited toZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 andsubsequent transactivation of ZNF148 target genes.{ECO:0000269|PubMed:15743823, ECO:0000269|PubMed:16608850,ECO:0000269|PubMed:18259216, ECO:0000269|PubMed:18946085,ECO:0000269|PubMed:19015314, ECO:0000269|PubMed:19680224,ECO:0000269|PubMed:22872859}. Rho GTPase-activating protein which may be involved inclathrin-mediated endocytosis. GTPase activators for the Rho-typeGTPases act by converting them to an inactive GDP-bound state. Hasactivity toward CDC42 and RAC1 (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SENP3_ARHGAP27


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SENP3_ARHGAP27


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SENP3SUMO2, PARP1, MEF2D, HIC1, PELP1, STUB1, HSP90AA1, MDM2, TP53, PIDD1, NR1H2, NPM1, RPLP0, RPS4X, RPS8, RPS11, RPS18, CDKN2A, TRIM63, TRIM54, USP21, USP15, MOV10, DHX15, ILF3, CHCHD4, CDK4, CDK6, LAS1L, SOX2, HECW2, RBBP5, WDR5, KMT2A, KMT2D, ASH2L, MEN1, EP300, HIF1A, NXF1, RNF2, CDCA8, RPL13, WDR18, HIST1H2BA, NTRK1, TEX10, IFI16, TCTN3, CEP164, DAXX, FOXQ1, CDC5L, CUL1, CUL3, XRCC5, SP1, UBE3A, XAB2, KPNB1, MCM4, NUP93, ELAC2, GTF3C4, NCBP1, TELO2, MAD1L1, MCM3, DDX27, UBTF, VCP, ZW10, TRIM28, MATR3, NSUN2, HNRNPUL1, RRP1B, ZC3H14, MCM5, NCAPH, MCM7, SSRP1, MRE11A, DDX17, PSMD2, COPG1, COPG2, PYGL, PYGB, GANAB, PDCD6IP, EEF2, HSP90B1, TRRAP, MOGS, VPS35, AP1G1, UFL1, RRM1, CSDE1, SEC63, QARS, ALDH18A1, MAGED1, PFKP, TFRC, GPHN, ACIN1, IMMT, HSP90AB1, TARS, ZNF746, NOL9, PHF19, TNFRSF13B, TRIM25ARHGAP27RAC1, CDC42, SH3KBP1, TRIM25


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SENP3_ARHGAP27


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SENP3_ARHGAP27


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource