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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33189

FusionGeneSummary for SENP2_CLCN2

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP2_CLCN2
Fusion gene ID: 33189
HgeneTgene
Gene symbol

SENP2

CLCN2

Gene ID

59343

1181

Gene nameSUMO specific peptidase 2chloride voltage-gated channel 2
SynonymsAXAM2|SMT3IP2CIC-2|CLC2|ECA2|ECA3|EGI11|EGI3|EGMA|EJM6|EJM8|LKPAT|clC-2
Cytomap

3q27.2

3q27.1

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 2SMT3-specific isopeptidase 2SUMO1/sentrin/SMT3 specific peptidase 2SUMO1/sentrin/SMT3 specific protease 2sentrin (SUMO1) specific peptidase 2sentrin/SUMO-specific protease SENP2chloride channel protein 2chloride channel 2chloride channel, voltage-sensitive 2
Modification date2018052320180523
UniProtAcc

Q9HC62

P51788

Ensembl transtripts involved in fusion geneENST00000545472, ENST00000296257, 
ENST00000427465, ENST00000465201, 
ENST00000265593, ENST00000344937, 
ENST00000423355, ENST00000434054, 
ENST00000457512, ENST00000475279, 
Fusion gene scores* DoF score8 X 6 X 8=3842 X 2 X 2=8
# samples 92
** MAII scorelog2(9/384*10)=-2.09310940439148
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context

PubMed: SENP2 [Title/Abstract] AND CLCN2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSENP2

GO:0016926

protein desumoylation

20194620

HgeneSENP2

GO:0031397

negative regulation of protein ubiquitination

22028379


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-91-8499-01ASENP2chr3

185304302

+CLCN2chr3

184076919

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000545472ENST00000265593SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-3CDSENST00000545472ENST00000344937SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000545472ENST00000423355SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000545472ENST00000434054SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000545472ENST00000457512SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-intronENST00000545472ENST00000475279SENP2chr3

185304302

+CLCN2chr3

184076919

-
Frame-shiftENST00000296257ENST00000265593SENP2chr3

185304302

+CLCN2chr3

184076919

-
Frame-shiftENST00000296257ENST00000344937SENP2chr3

185304302

+CLCN2chr3

184076919

-
5CDS-5UTRENST00000296257ENST00000423355SENP2chr3

185304302

+CLCN2chr3

184076919

-
5CDS-5UTRENST00000296257ENST00000434054SENP2chr3

185304302

+CLCN2chr3

184076919

-
5CDS-5UTRENST00000296257ENST00000457512SENP2chr3

185304302

+CLCN2chr3

184076919

-
5CDS-intronENST00000296257ENST00000475279SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-3CDSENST00000427465ENST00000265593SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-3CDSENST00000427465ENST00000344937SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-5UTRENST00000427465ENST00000423355SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-5UTRENST00000427465ENST00000434054SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-5UTRENST00000427465ENST00000457512SENP2chr3

185304302

+CLCN2chr3

184076919

-
5UTR-intronENST00000427465ENST00000475279SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-3CDSENST00000465201ENST00000265593SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-3CDSENST00000465201ENST00000344937SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000465201ENST00000423355SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000465201ENST00000434054SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-5UTRENST00000465201ENST00000457512SENP2chr3

185304302

+CLCN2chr3

184076919

-
intron-intronENST00000465201ENST00000475279SENP2chr3

185304302

+CLCN2chr3

184076919

-

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FusionProtFeatures for SENP2_CLCN2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP2

Q9HC62

CLCN2

P51788

Protease that catalyzes two essential functions in theSUMO pathway. The first is the hydrolysis of an alpha-linkedpeptide bond at the C-terminal end of the small ubiquitin-likemodifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to themature form of the proteins. The second is the deconjugation ofSUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving anepsilon-linked peptide bond between the C-terminal glycine of themature SUMO and the lysine epsilon-amino group of the targetprotein. May down-regulate CTNNB1 levels and thereby modulate theWnt pathway. Deconjugates SUMO2 from MTA1. Plays a dynamic role inadipogenesis by desumoylating and promoting the stabilization ofCEBPB (PubMed:20194620). {ECO:0000250|UniProtKB:Q91ZX6,ECO:0000250|UniProtKB:Q9EQE1, ECO:0000269|PubMed:11896061,ECO:0000269|PubMed:12192048, ECO:0000269|PubMed:20194620,ECO:0000269|PubMed:21965678}. Voltage-gated chloride channel. Chloride channels haveseveral functions including the regulation of cell volume;membrane potential stabilization, signal transduction andtransepithelial transport. {ECO:0000269|PubMed:19153159,ECO:0000269|PubMed:19191339}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SENP2_CLCN2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SENP2_CLCN2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SENP2CDK5RAP2, NUP153, SUMO1, SUMO3, IKBKG, NEDD4L, ELAVL1, HIPK2, DAXX, TRIM63, APP, HNRNPK, TPD52, CDCA5, RANGAP1, SUMO2, ARL6IP1, AGTRAP, FUNDC1, CCDC155, SYNE4, TMEM239, FZR1, NUP43, NUP107, NUP133, TMEM17, TMEM216, NACC1, BCOR, MYC, CTDNEP1, USP28, PGK2, KPNA1, KPNB1, LMNACLCN2PPP1CA, ATXN1, EIF4G1, NVL, PEX10, SRP14, SRSF8, RAB11FIP2, KLHDC2, GPKOW, ZCCHC10, CCDC94, MUC13, SNIP1, ZNF668, FAM192A, TOE1, DNTTIP1, C1orf52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SENP2_CLCN2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgeneCLCN2P51788DB01046LubiprostoneChloride channel protein 2small moleculeapproved|investigational

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RelatedDiseases for SENP2_CLCN2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneCLCN2C0017638Glioma1CTD_human
TgeneCLCN2C2750893EPILEPSY, IDIOPATHIC GENERALIZED, SUSCEPTIBILITY TO, 111UNIPROT
TgeneCLCN2C3810242LEUKOENCEPHALOPATHY WITH ATAXIA1ORPHANET;UNIPROT