FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact
Center for Computational Systems Medicine
leaf

FusionGeneSummary

leaf

FusionProtFeature

leaf

FusionGeneSequence

leaf

FusionGenePPI

leaf

RelatedDrugs

leaf

RelatedDiseases

Fusion gene ID: 33186

FusionGeneSummary for SENP1_SPDYA

check button Fusion gene summary
Fusion gene informationFusion gene name: SENP1_SPDYA
Fusion gene ID: 33186
HgeneTgene
Gene symbol

SENP1

SPDYA

Gene ID

29843

245711

Gene nameSUMO specific peptidase 1speedy/RINGO cell cycle regulator family member A
SynonymsSuPr-2RINGO3|RINGOA|SPDY1|SPY1
Cytomap

12q13.11

2p23.2

Type of geneprotein-codingprotein-coding
Descriptionsentrin-specific protease 1SUMO1/sentrin specific peptidase 1SUMO1/sentrin specific protease 1sentrin/SUMO-specific protease SENP1speedy protein ARINGO AhSpy/Ringo Arapid inducer of G2/M progression in oocytes Aspeedy homolog Aspeedy-1
Modification date2018052320180519
UniProtAcc

Q9P0U3

Q5MJ70

Ensembl transtripts involved in fusion geneENST00000339976, ENST00000004980, 
ENST00000448372, ENST00000551330, 
ENST00000549518, ENST00000549595, 
ENST00000547886, 		ENST00000462832, 
ENST00000379579, ENST00000334056, 
Fusion gene scores* DoF score5 X 5 X 2=504 X 4 X 1=16
# samples 64
** MAII scorelog2(6/50*10)=0.263034405833794
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SENP1 [Title/Abstract] AND SPDYA [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneSPDYA

GO:0000082

G1/S transition of mitotic cell cycle

11980914

TgeneSPDYA

GO:0006974

cellular response to DNA damage stimulus

12839962

TgeneSPDYA

GO:0008284

positive regulation of cell proliferation

11980914

TgeneSPDYA

GO:0045860

positive regulation of protein kinase activity

28666995


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BI462236SENP1chr12

48490119

-SPDYAchr2

29041912

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000339976ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000339976ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000339976ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000004980ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000004980ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000004980ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000448372ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000448372ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000448372ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000551330ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000551330ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000551330ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549518ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549518ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549518ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549595ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549595ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5CDS-3UTRENST00000549595ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+
5UTR-3UTRENST00000547886ENST00000462832SENP1chr12

48490119

-SPDYAchr2

29041912

+
5UTR-3UTRENST00000547886ENST00000379579SENP1chr12

48490119

-SPDYAchr2

29041912

+
5UTR-3UTRENST00000547886ENST00000334056SENP1chr12

48490119

-SPDYAchr2

29041912

+

Top

FusionProtFeatures for SENP1_SPDYA


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SENP1

Q9P0U3

SPDYA

Q5MJ70

Protease that catalyzes two essential functions in theSUMO pathway (PubMed:10652325, PubMed:15199155, PubMed:16253240,PubMed:16553580, PubMed:21829689, PubMed:21965678,PubMed:23160374, PubMed:24943844, PubMed:25406032,PubMed:29506078). The first is the hydrolysis of an alpha-linkedpeptide bond at the C-terminal end of the small ubiquitin-likemodifier (SUMO) propeptides, SUMO1, SUMO2 and SUMO3 leading to themature form of the proteins. The second is the deconjugation ofSUMO1, SUMO2 and SUMO3 from targeted proteins, by cleaving anepsilon-linked peptide bond between the C-terminal glycine of themature SUMO and the lysine epsilon-amino group of the targetprotein. Deconjugates SUMO1 from HIPK2 (PubMed:16253240).Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreasesits transcriptional repression activity (PubMed:21829689).Deconjugates SUMO1 from CLOCK, which decreases its transcriptionalactivation activity (PubMed:23160374). Deconjugates SUMO2 fromMTA1 (PubMed:21965678). Deconjugates SUMO1 from METTL3(PubMed:29506078). Desumoylates CCAR2 which decreases itsinteraction with SIRT1 (PubMed:25406032). Deconjugates SUMO1 fromGPS2 (PubMed:24943844). {ECO:0000269|PubMed:10652325,ECO:0000269|PubMed:15199155, ECO:0000269|PubMed:16253240,ECO:0000269|PubMed:16553580, ECO:0000269|PubMed:21829689,ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:23160374,ECO:0000269|PubMed:24943844, ECO:0000269|PubMed:25406032,ECO:0000269|PubMed:29506078}. Regulates the G1/S phase transition of the cell cycle bybinding and activating CDK1 and CDK2 (PubMed:12972555).Contributes to CDK2 activation without promoting CDK2phosphorylation, by inducing a conformation change of the CDK2 T-loop that obstructs the substrate-binding cleft prior to kinaseactivation (PubMed:28666995). Mediates cell survival during theDNA damage process through activation of CDK2 (PubMed:12839962).{ECO:0000269|PubMed:11980914, ECO:0000269|PubMed:12839962,ECO:0000269|PubMed:12972555, ECO:0000269|PubMed:28666995}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

FusionGeneSequence for SENP1_SPDYA


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

Top

FusionGenePPI for SENP1_SPDYA


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SENP1_SPDYA


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SENP1_SPDYA


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource