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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33161

FusionGeneSummary for SEMA4D_RGS3

check button Fusion gene summary
Fusion gene informationFusion gene name: SEMA4D_RGS3
Fusion gene ID: 33161
HgeneTgene
Gene symbol

SEMA4D

RGS3

Gene ID

10507

5998

Gene namesemaphorin 4Dregulator of G protein signaling 3
SynonymsC9orf164|CD100|COLL4|M-sema-G|SEMAJ|coll-4C2PA|RGP3
Cytomap

9q22.2

9q32

Type of geneprotein-codingprotein-coding
Descriptionsemaphorin-4DA8BB18GR3sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4Dregulator of G-protein signaling 3regulator of G-protein signalling 3
Modification date2018052720180519
UniProtAcc

Q92854

P49796

Ensembl transtripts involved in fusion geneENST00000339861, ENST00000420987, 
ENST00000455551, ENST00000343780, 
ENST00000450295, ENST00000438547, 
ENST00000356444, ENST00000422704, 
ENST00000420101, ENST00000469653, 
ENST00000374140, ENST00000350696, 
ENST00000317613, ENST00000343817, 
ENST00000394646, ENST00000374136, 
ENST00000462143, ENST00000463806, 
ENST00000342620, ENST00000374134, 
ENST00000462403, 
Fusion gene scores* DoF score2 X 3 X 2=124 X 4 X 2=32
# samples 34
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEMA4D [Title/Abstract] AND RGS3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEMA4D

GO:0001934

positive regulation of protein phosphorylation

16055703

HgeneSEMA4D

GO:0007162

negative regulation of cell adhesion

15218527

HgeneSEMA4D

GO:0030335

positive regulation of cell migration

16055703

HgeneSEMA4D

GO:0071526

semaphorin-plexin signaling pathway

15218527


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVPRADTCGA-XQ-A8TA-01ASEMA4Dchr9

92112834

-RGS3chr9

116241771

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000339861ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000339861ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000339861ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000339861ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420987ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420987ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420987ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420987ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000455551ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000455551ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000455551ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000455551ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000343780ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000343780ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000343780ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000343780ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000450295ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000450295ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000450295ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000450295ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000438547ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000438547ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000438547ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000438547ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000356444ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000356444ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000356444ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000356444ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000422704ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000422704ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-3CDSENST00000422704ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
5UTR-intronENST00000422704ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420101ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420101ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000420101ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000420101ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000469653ENST00000374140SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000469653ENST00000350696SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-3CDSENST00000469653ENST00000317613SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000343817SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000394646SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000374136SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000462143SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000463806SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000342620SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000374134SEMA4Dchr9

92112834

-RGS3chr9

116241771

+
intron-intronENST00000469653ENST00000462403SEMA4Dchr9

92112834

-RGS3chr9

116241771

+

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FusionProtFeatures for SEMA4D_RGS3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEMA4D

Q92854

RGS3

P49796

Cell surface receptor for PLXN1B and PLXNB2 that playsan important role in cell-cell signaling. Promotes reorganizationof the actin cytoskeleton and plays a role in axonal growth coneguidance in the developing central nervous system. Regulatesdendrite and axon branching and morphogenesis. Promotes themigration of cerebellar granule cells and of endothelial cells.Plays a role in the immune system; induces B-cells to aggregateand improves their viability (in vitro). Promotes signaling viaSRC and PTK2B/PYK2, which then mediates activation ofphosphatidylinositol 3-kinase and of the AKT1 signaling cascade.Interaction with PLXNB1 mediates activation of RHOA.{ECO:0000269|PubMed:16055703, ECO:0000269|PubMed:19788569,ECO:0000269|PubMed:20877282, ECO:0000269|PubMed:8876214}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEMA4D_RGS3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEMA4D_RGS3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEMA4DCD72, PTPRC, SEMA4D, PLXNB1, ELAVL1, CRK, SCGB2A2, SCGB1D1, VCAM1, ST8SIA4RGS3GNAI3, GNA11, YWHAB, YWHAZ, ISG15, IRF5, ARRB1, ACD, APP, GNAI2, HES4, PLSCR1, GORASP2, CRAT, UACA, SKAP2, CEP72, RBAK, EFNB2, ATG9A, ZKSCAN8, ZNF24, REL, KCTD2, ZNF324B, CORO2A, ISCA1, EFNB1, CEP44, EFNB3, ZNF646, ZNF446, CKAP4, KLHL24, ZSCAN30, SEPT10, ZNF397, SEPT2, PDLIM7, ZNF460, KLHL23, KCTD17, KIAA0232, ISCA2, SEPT8


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEMA4D_RGS3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEMA4D_RGS3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneRGS3C0023893Liver Cirrhosis, Experimental1CTD_human