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Fusion gene ID: 33160 |
FusionGeneSummary for SEMA4C_WNT5B |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEMA4C_WNT5B | Fusion gene ID: 33160 | Hgene | Tgene | Gene symbol | SEMA4C | WNT5B | Gene ID | 54910 | 81029 |
| Gene name | semaphorin 4C | Wnt family member 5B | |
| Synonyms | M-SEMA-F|SEMACL1|SEMAF|SEMAI | - | |
| Cytomap | 2q11.2 | 12p13.33 | |
| Type of gene | protein-coding | protein-coding | |
| Description | semaphorin-4CM-Sema Fsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C | protein Wnt-5bWNT-5B proteinwingless-type MMTV integration site family, member 5B | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9C0C4 | Q9H1J7 | |
| Ensembl transtripts involved in fusion gene | ENST00000305476, | ENST00000537031, ENST00000310594, ENST00000397196, ENST00000542408, ENST00000545747, | |
| Fusion gene scores | * DoF score | 4 X 4 X 4=64 | 5 X 2 X 3=30 |
| # samples | 6 | 5 | |
| ** MAII score | log2(6/64*10)=-0.0931094043914815 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(5/30*10)=0.736965594166206 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SEMA4C [Title/Abstract] AND WNT5B [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | SEMA4C | GO:0032874 | positive regulation of stress-activated MAPK cascade | 17498836 |
| Hgene | SEMA4C | GO:0042692 | muscle cell differentiation | 17498836 |
| Tgene | WNT5B | GO:0016055 | Wnt signaling pathway | 15731909 |
| Tgene | WNT5B | GO:0030335 | positive regulation of cell migration | 19486338 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | BRCA | TCGA-AO-A124-01A | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5CDS-5UTR | ENST00000305476 | ENST00000537031 | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
| 5CDS-5UTR | ENST00000305476 | ENST00000310594 | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
| 5CDS-5UTR | ENST00000305476 | ENST00000397196 | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
| 5CDS-intron | ENST00000305476 | ENST00000542408 | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
| 5CDS-intron | ENST00000305476 | ENST00000545747 | SEMA4C | chr2 | 97529419 | - | WNT5B | chr12 | 1740464 | + |
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FusionProtFeatures for SEMA4C_WNT5B |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEMA4C | WNT5B |
| Cell surface receptor for PLXNB2 that plays an importantrole in cell-cell signaling. PLXNB2 binding promotes downstreamactivation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.Required for normal brain development, axon guidance and cellmigration (By similarity). Probable signaling receptor which mayplay a role in myogenic differentiation through activation of thestress-activated MAPK cascade. {ECO:0000250,ECO:0000269|PubMed:17498836}. | Ligand for members of the frizzled family of seventransmembrane receptors. Probable developmental protein. May be asignaling molecule which affects the development of discreteregions of tissues. Is likely to signal over only few celldiameters (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA4C_WNT5B |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEMA4C_WNT5B |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SEMA4C | DLG4, DLG3, DLG2, FBXO6, KRT31, PNMA1, RCHY1, KRT40, NOTCH2NL, ATP1B3, SPACA1, MCOLN3, TMEM30A, ATP1B4, VSIG4, TNF, HTR3C, TMEM17, TMEM30B, TNFSF8, IL13RA2, TRIM25 | WNT5B | APPBP2, WNT5A, KLRG2 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA4C_WNT5B |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA4C_WNT5B |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | WNT5B | C0010606 | Adenoid Cystic Carcinoma | 1 | CTD_human |
| Tgene | WNT5B | C0023267 | Fibroid Tumor | 1 | CTD_human |
| Tgene | WNT5B | C0036095 | Salivary Gland Neoplasms | 1 | CTD_human |
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