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Fusion gene ID: 33151 |
FusionGeneSummary for SEMA4B_CERS3 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEMA4B_CERS3 | Fusion gene ID: 33151 | Hgene | Tgene | Gene symbol | SEMA4B | CERS3 | Gene ID | 10509 | 204219 |
| Gene name | semaphorin 4B | ceramide synthase 3 | |
| Synonyms | SEMAC|SemC | ARCI9|LASS3 | |
| Cytomap | 15q26.1 | 15q26.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | semaphorin-4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4Bsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4B | ceramide synthase 3LAG1 homolog, ceramide synthase 3LAG1 longevity assurance homolog 3dihydroceramide synthase 3 | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q9NPR2 | Q8IU89 | |
| Ensembl transtripts involved in fusion gene | ENST00000379122, ENST00000332496, ENST00000560263, ENST00000411539, | ENST00000284382, ENST00000538112, ENST00000394113, ENST00000560944, | |
| Fusion gene scores | * DoF score | 7 X 6 X 6=252 | 5 X 3 X 5=75 |
| # samples | 11 | 6 | |
| ** MAII score | log2(11/252*10)=-1.19592020997526 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(6/75*10)=-0.321928094887362 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: SEMA4B [Title/Abstract] AND CERS3 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | LD | LUAD | TCGA-J2-A4AD-01A | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000379122 | ENST00000284382 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| Frame-shift | ENST00000379122 | ENST00000538112 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| In-frame | ENST00000379122 | ENST00000394113 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| 5CDS-5UTR | ENST00000379122 | ENST00000560944 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| Frame-shift | ENST00000332496 | ENST00000284382 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| Frame-shift | ENST00000332496 | ENST00000538112 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| In-frame | ENST00000332496 | ENST00000394113 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| 5CDS-5UTR | ENST00000332496 | ENST00000560944 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| intron-3CDS | ENST00000560263 | ENST00000284382 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| intron-3CDS | ENST00000560263 | ENST00000538112 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| intron-3CDS | ENST00000560263 | ENST00000394113 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| intron-5UTR | ENST00000560263 | ENST00000560944 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| Frame-shift | ENST00000411539 | ENST00000284382 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| Frame-shift | ENST00000411539 | ENST00000538112 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| In-frame | ENST00000411539 | ENST00000394113 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
| 5CDS-5UTR | ENST00000411539 | ENST00000560944 | SEMA4B | chr15 | 90744967 | + | CERS3 | chr15 | 100943070 | - |
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FusionProtFeatures for SEMA4B_CERS3 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEMA4B | CERS3 |
| Inhibits axonal extension by providing local signals tospecify territories inaccessible for growing axons. {ECO:0000250}. | Has (dihydro)ceramide synthesis activity with relativelybroad substrate specificity, but a preference for C18:0 and othermiddle- to long-chain fatty acyl-CoAs (By similarity). It iscrucial for the synthesis of very long-chain ceramides in theepidermis, to maintain epidermal lipid homeostasis and terminaldifferentiation. {ECO:0000250, ECO:0000269|PubMed:23754960}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEMA4B_CERS3 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SEMA4B_ENST00000379122_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_98aa MGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLEHPGCEEXXRGLXRGRGRGRRRGYQRQRDGLFKERPQGXEAPH >In-frame_SEMA4B_ENST00000332496_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_103aa MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLEHPGCEEXXRGLXRGRGRGRRRGYQRQRDGLFKERPQG >In-frame_SEMA4B_ENST00000411539_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_103aa MLRTAMGLRSWLAAPWGALPPRPPLLLLLLLLLLLQPPPPTWALSPRISLPLEHPGCEEXXRGLXRGRGRGRRRGYQRQRDGLFKERPQG |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SEMA4B_ENST00000379122_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_295nt ATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTG CAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGA AGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCAT >In-frame_SEMA4B_ENST00000332496_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_310nt ATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTG CTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGA TGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGC >In-frame_SEMA4B_ENST00000411539_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_310nt ATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTG CTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGA TGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGC |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SEMA4B_ENST00000379122_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_795nt ATTTCCGGGGACGCCGCGCCGGACTGAGGCTGTGCGCCCGAGACTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACG AGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGATGACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCC CCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGC TCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCT GCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGG ATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGA ACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTG CAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCT >In-frame_SEMA4B_ENST00000332496_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_752nt CTCCGGGTCCCCAGGGGCTGCGCCGGGCCGGCCTGGCAAGGGGGACGAGTCAGTGGACACTCCAGGAAGAGCGGCCCCGCGGGGGGCGAT GACCGTGCGCTGACCCTGACTCACTCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACCGCGGGGCGGAGCTGCCGCCC GTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCACCGCGATGGGCCTGAGGAGC TGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCCTGCTGCAGCCGCCGCCTCCG ACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGATGACGAGGATTATGAAGAGGAAGAGGAAGA GGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCACCTCATTCCCAATGGCCAGCA TGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCTTCCAGGCCCCACACCGACCC CACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTGTTAACTTGTGTTAAAATGTT >In-frame_SEMA4B_ENST00000411539_chr15_90744967_+_CERS3_ENST00000394113_chr15_100943070_-_772nt CGCCCTCCGCCGCTTGCGGGTGAGCTCTGCCCAAGCCGAGGCTGCGGGGCCGGCGCCGGCGGGAGGACTGCGGTGCCCCGCGGAGGGGCT GAGTTTGCCAGGGCCCACTTGACCCTGTTTCCCACCTCCCGCCCCCCAGGTCCGGAGGCGGGGGCCCCCGGGGCGACTCGGGGGCGGACC GCGGGGCGGAGCTGCCGCCCGTGAGTCCGGCCGAGCCACCTGAGCCCGAGCCGCGGGACACCGTCGCTCCTGCTCTCCGAATGCTGCGCA CCGCGATGGGCCTGAGGAGCTGGCTCGCCGCCCCATGGGGCGCGCTGCCGCCTCGGCCACCGCTGCTGCTGCTCCTGCTGCTGCTGCTCC TGCTGCAGCCGCCGCCTCCGACCTGGGCGCTCAGCCCCCGGATCAGCCTGCCTCTGGAGCATCCAGGATGTGAGGAGTGATGACGAGGAT TATGAAGAGGAAGAGGAAGAGGAAGAAGAAGAGGCTACCAAAGGCAAAGAGATGGATTGTTTAAAGAACGGCCTCAGGGCTGAGAGGCAC CTCATTCCCAATGGCCAGCATGGCCATTAGCTGGAAGCCTACAGGACTCCCATGGCACAGCATGCTGCAAGTACTGTTGGCAGCCTGGCT TCCAGGCCCCACACCGACCCCACATTCTGCCCTTCCCTCTTTCTCACCACCGCCTTCCCTCCCACCTAAGATGTGTTTACCAAAATGTTG |
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FusionGenePPI for SEMA4B_CERS3 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SEMA4B | DCBLD2, AEN | CERS3 | PTPRE |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEMA4B_CERS3 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEMA4B_CERS3 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
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