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Fusion gene ID: 3314 |
FusionGeneSummary for ATP1B1_IL26 |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: ATP1B1_IL26 | Fusion gene ID: 3314 | Hgene | Tgene | Gene symbol | ATP1B1 | IL26 | Gene ID | 481 | 55801 |
| Gene name | ATPase Na+/K+ transporting subunit beta 1 | interleukin 26 | |
| Synonyms | ATP1B | AK155|IL-26 | |
| Cytomap | 1q24.2 | 12q15 | |
| Type of gene | protein-coding | protein-coding | |
| Description | sodium/potassium-transporting ATPase subunit beta-1ATPase, Na+/K+ transporting, beta 1 polypeptideBeta 1-subunit of Na(+),K(+)-ATPaseNa, K-ATPase beta-1 polypeptideadenosinetriphosphatasesodium pump subunit beta-1sodium-potassium ATPase subunit beta | interleukin-26 | |
| Modification date | 20180523 | 20180519 | |
| UniProtAcc | P05026 | Q9NPH9 | |
| Ensembl transtripts involved in fusion gene | ENST00000367816, ENST00000367815, ENST00000499679, ENST00000367813, | ENST00000229134, | |
| Fusion gene scores | * DoF score | 9 X 8 X 6=432 | 4 X 2 X 1=8 |
| # samples | 12 | 4 | |
| ** MAII score | log2(12/432*10)=-1.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(4/8*10)=2.32192809488736 | |
| Context | PubMed: ATP1B1 [Title/Abstract] AND IL26 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ATP1B1 | GO:0006883 | cellular sodium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B1 | GO:0010107 | potassium ion import | 10636900|19542013 |
| Hgene | ATP1B1 | GO:0030007 | cellular potassium ion homeostasis | 10636900|19542013 |
| Hgene | ATP1B1 | GO:0032781 | positive regulation of ATPase activity | 10636900 |
| Hgene | ATP1B1 | GO:0036376 | sodium ion export across plasma membrane | 10636900|19542013 |
| Hgene | ATP1B1 | GO:0046034 | ATP metabolic process | 23954377 |
| Hgene | ATP1B1 | GO:0050821 | protein stabilization | 10636900 |
| Hgene | ATP1B1 | GO:0072659 | protein localization to plasma membrane | 18522992 |
| Hgene | ATP1B1 | GO:0086009 | membrane repolarization | 19542013 |
| Hgene | ATP1B1 | GO:1901018 | positive regulation of potassium ion transmembrane transporter activity | 10636900 |
| Hgene | ATP1B1 | GO:1903278 | positive regulation of sodium ion export across plasma membrane | 10636900 |
| Hgene | ATP1B1 | GO:1903288 | positive regulation of potassium ion import | 10636900 |
| Tgene | IL26 | GO:0032874 | positive regulation of stress-activated MAPK cascade | 18483078 |
| Tgene | IL26 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 18483078 |
| Tgene | IL26 | GO:0046427 | positive regulation of JAK-STAT cascade | 18483078 |
| Tgene | IL26 | GO:0050680 | negative regulation of epithelial cell proliferation | 18483078 |
| Tgene | IL26 | GO:0050715 | positive regulation of cytokine secretion | 18483078 |
| Tgene | IL26 | GO:0051897 | positive regulation of protein kinase B signaling | 18483078 |
| Tgene | IL26 | GO:0070374 | positive regulation of ERK1 and ERK2 cascade | 18483078 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A1KU-01A | ATP1B1 | chr1 | 169080736 | + | IL26 | chr12 | 68619063 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| Frame-shift | ENST00000367816 | ENST00000229134 | ATP1B1 | chr1 | 169080736 | + | IL26 | chr12 | 68619063 | - |
| Frame-shift | ENST00000367815 | ENST00000229134 | ATP1B1 | chr1 | 169080736 | + | IL26 | chr12 | 68619063 | - |
| Frame-shift | ENST00000499679 | ENST00000229134 | ATP1B1 | chr1 | 169080736 | + | IL26 | chr12 | 68619063 | - |
| Frame-shift | ENST00000367813 | ENST00000229134 | ATP1B1 | chr1 | 169080736 | + | IL26 | chr12 | 68619063 | - |
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FusionProtFeatures for ATP1B1_IL26 |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ATP1B1 | IL26 |
| This is the non-catalytic component of the activeenzyme, which catalyzes the hydrolysis of ATP coupled with theexchange of Na(+) and K(+) ions across the plasma membrane. Thebeta subunit regulates, through assembly of alpha/betaheterodimers, the number of sodium pumps transported to the plasmamembrane. {ECO:0000269|PubMed:19694409}. Involved in cell adhesion and establishing epithelialcell polarity. {ECO:0000269|PubMed:19694409}. | May play a role in local mechanisms of mucosal immunityand seems to have a proinflammatory function. May play a role ininflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3(ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha andIL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1.Decreases proliferation of intestinal epithelial cells. Isinhibited by heparin. {ECO:0000269|PubMed:14764663,ECO:0000269|PubMed:15178681, ECO:0000269|PubMed:18483078}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for ATP1B1_IL26 |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for ATP1B1_IL26 |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| ATP1B1 | FXYD1, LRIF1, NDRG2, HLA-DRA, HLA-DRB1, HLA-DRB3, HLA-DRB4, HLA-DRB5, KMT2B, TRMT2A, DDAH2, PSME1, CRIP2, EZH2, ELAVL1, NEDD4L, USP4, GCH1, BARD1, BRCA1, PAXIP1, ATP4A, EGFR, CCDC8, ACAA2, ACAT1, ATP1A1, ACO2, ATP6V1E1, DLD, HADHA, HADHB, HNRNPA2B1, HNRNPA3, HSD17B10, ILVBL, LMAN1, MRPS35, PDHA1, RAB1A, RTN4, SDHA, ATP2A2, ATP5F1, ATP5L, CANX, COX6B1, CPT2, CTSD, CYC1, DLAT, EIF4H, FUBP1, HSD17B12, MTCH1, MTCH2, NDUFA12, NDUFA2, NDUFS1, NDUFS3, NDUFV1, PSMD6, RAB1B, RPL26, RPS19, TOMM40, UQCRB, UQCRFS1, UQCRQ, VDAC1, NTRK1, TSC22D2, PDCD5, TRIM25 | IL26 | APP |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for ATP1B1_IL26 |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for ATP1B1_IL26 |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | ATP1B1 | C0023467 | Leukemia, Myelocytic, Acute | 1 | CTD_human |
| Hgene | ATP1B1 | C0236969 | Substance-Related Disorders | 1 | CTD_human |
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