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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33104

FusionGeneSummary for SEC63_SCML4

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC63_SCML4
Fusion gene ID: 33104
HgeneTgene
Gene symbol

SEC63

SCML4

Gene ID

11231

256380

Gene nameSEC63 homolog, protein translocation regulatorScm polycomb group protein like 4
SynonymsDNAJC23|ERdj2|PCLD2|PRO2507|SEC63LdJ47M23.1
Cytomap

6q21

6q21

Type of geneprotein-codingprotein-coding
Descriptiontranslocation protein SEC63 homologSEC63 protein translocation regulatorSEC63-like proteinsex comb on midleg-like protein 4sex comb on midleg like 4
Modification date2018052320180519
UniProtAcc

Q9UGP8

Q8N228

Ensembl transtripts involved in fusion geneENST00000369002, ENST00000460009, 
ENST00000369022, ENST00000369020, 
ENST00000369025, ENST00000369021, 
ENST00000479803, 
Fusion gene scores* DoF score6 X 7 X 4=1683 X 3 X 3=27
# samples 83
** MAII scorelog2(8/168*10)=-1.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC63 [Title/Abstract] AND SCML4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-BH-A1FE-01ASEC63chr6

108279090

-SCML4chr6

108071017

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000369002ENST00000369022SEC63chr6

108279090

-SCML4chr6

108071017

-
5CDS-5UTRENST00000369002ENST00000369020SEC63chr6

108279090

-SCML4chr6

108071017

-
5CDS-intronENST00000369002ENST00000369025SEC63chr6

108279090

-SCML4chr6

108071017

-
5CDS-intronENST00000369002ENST00000369021SEC63chr6

108279090

-SCML4chr6

108071017

-
5CDS-intronENST00000369002ENST00000479803SEC63chr6

108279090

-SCML4chr6

108071017

-
5UTR-5UTRENST00000460009ENST00000369022SEC63chr6

108279090

-SCML4chr6

108071017

-
5UTR-5UTRENST00000460009ENST00000369020SEC63chr6

108279090

-SCML4chr6

108071017

-
5UTR-intronENST00000460009ENST00000369025SEC63chr6

108279090

-SCML4chr6

108071017

-
5UTR-intronENST00000460009ENST00000369021SEC63chr6

108279090

-SCML4chr6

108071017

-
5UTR-intronENST00000460009ENST00000479803SEC63chr6

108279090

-SCML4chr6

108071017

-

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FusionProtFeatures for SEC63_SCML4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC63

Q9UGP8

SCML4

Q8N228

Required for integral membrane and secreted preproteintranslocation across the endoplasmic reticulum membrane. Putative Polycomb group (PcG) protein. PcG proteins actby forming multiprotein complexes, which are required to maintainthe transcriptionally repressive state of homeotic genesthroughout development (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC63_SCML4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC63_SCML4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC63GSTK1, IRF1, PMF1, SPA17, GPR183, RFX3, GPRC5D, SKAP1, ACADM, RPS5, ABCC1, DDOST, KPNA4, SEC61A1, NTRK1, TP53, OFD1, TCTN2, TCTN3, NPHP1, RPGRIP1L, EVC2, TCTN1, TMEM17, TMEM216, HSPA5, SENP3, CDKN3, YIPF3, HTR2C, ARFGAP1, BIN3, GPRC5B, TPTE, NR3C1, TRIM25SCML4UBR1, FBXO11, KDM5C


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC63_SCML4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC63_SCML4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC63C0022680Polycystic Kidney Diseases1CTD_human
HgeneSEC63C0158683Polycystic liver disease1CTD_human;HPO;ORPHANET