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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33091

FusionGeneSummary for SEC61G_IKZF1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC61G_IKZF1
Fusion gene ID: 33091
HgeneTgene
Gene symbol

SEC61G

IKZF1

Gene ID

23480

10320

Gene nameSec61 translocon gamma subunitIKAROS family zinc finger 1
SynonymsSSS1CVID13|Hs.54452|IK1|IKAROS|LYF1|LyF-1|PPP1R92|PRO0758|ZNFN1A1
Cytomap

7p11.2

7p12.2

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec61 subunit gammaSec61 gamma subunitprotein transport protein SEC61 gamma subunitDNA-binding protein IkarosCLL-associated antigen KW-6ikaros family zinc finger protein 1lymphoid transcription factor LyF-1protein phosphatase 1, regulatory subunit 92zinc finger protein, subfamily 1A, 1 (Ikaros)
Modification date2018052220180527
UniProtAcc

P60059

Q13422

Ensembl transtripts involved in fusion geneENST00000395535, ENST00000352861, 
ENST00000415949, ENST00000450622, 
ENST00000440768, ENST00000359197, 
ENST00000343574, ENST00000331340, 
ENST00000349824, ENST00000357364, 
ENST00000346667, ENST00000438033, 
ENST00000439701, ENST00000413698, 
ENST00000492782, 
Fusion gene scores* DoF score8 X 5 X 3=1206 X 6 X 3=108
# samples 86
** MAII scorelog2(8/120*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC61G [Title/Abstract] AND IKZF1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-DU-A5TY-01ASEC61Gchr7

54825188

-IKZF1chr7

50435704

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000395535ENST00000440768SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000359197SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000343574SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000331340SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000349824SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000357364SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000346667SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000438033SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000439701SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000395535ENST00000413698SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-3UTRENST00000395535ENST00000492782SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000440768SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000359197SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000343574SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000331340SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000349824SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000357364SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000346667SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000438033SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000439701SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000352861ENST00000413698SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-3UTRENST00000352861ENST00000492782SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000440768SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000359197SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000343574SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000331340SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000349824SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000357364SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000346667SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000438033SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000439701SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000415949ENST00000413698SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-3UTRENST00000415949ENST00000492782SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000440768SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000359197SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000343574SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000331340SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000349824SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000357364SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000346667SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000438033SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000439701SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-intronENST00000450622ENST00000413698SEC61Gchr7

54825188

-IKZF1chr7

50435704

+
5CDS-3UTRENST00000450622ENST00000492782SEC61Gchr7

54825188

-IKZF1chr7

50435704

+

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FusionProtFeatures for SEC61G_IKZF1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC61G

P60059

IKZF1

Q13422

Necessary for protein translocation in the endoplasmicreticulum. {ECO:0000250}. Transcription regulator of hematopoietic celldifferentiation (PubMed:17934067). Binds gamma-satellite DNA(PubMed:17135265, PubMed:19141594). Plays a role in thedevelopment of lymphocytes, B- and T-cells. Binds and activatesthe enhancer (delta-A element) of the CD3-delta gene. Repressor ofthe TDT (fikzfterminal deoxynucleotidyltransferase) gene duringthymocyte differentiation. Regulates transcription throughassociation with both HDAC-dependent and HDAC-independentcomplexes. Targets the 2 chromatin-remodeling complexes, NuRD andBAF (SWI/SNF), in a single complex (PYR complex), to the beta-globin locus in adult erythrocytes. Increases normal apoptosis inadult erythroid cells. Confers early temporal competence toretinal progenitor cells (RPCs) (By similarity). Function isisoform-specific and is modulated by dominant-negative inactiveisoforms (PubMed:17135265, PubMed:17934067).{ECO:0000250|UniProtKB:Q03267, ECO:0000269|PubMed:10204490,ECO:0000269|PubMed:17135265, ECO:0000269|PubMed:17934067,ECO:0000269|PubMed:19141594}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC61G_IKZF1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC61G_IKZF1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC61GAURKA, TUBGCP3, SFTPC, CREB3, SEC61A1IKZF1UBE2I, AP2M1, CTBP1, RBBP8, SIN3A, NCOR2, TBP, GTF2B, SIN3B, HDAC1, CHD4, HDAC2, HDAC4, HDAC5, HDAC7, HDAC3, IKZF4, IKZF5, IKZF2, GATA1, SMARCE1, NUDT21, CSNK1G1, CDK2AP2, IKZF3, RBBP4, CHD3, SMARCA4, NOTCH1, HDAC11, TDG, CRBN, ANKRD11, PRKAB2, BYSL, CKS1B, CTBP2, DCX, DDX6, FGF12, PIN1, PSMA1, PSMA4, RAD51D, SDCBP, SNRPF, DYRK2, AP1M1, MTA1, WTAP, MORF4L2, RWDD2B, IKZF1, MCRS1, MAD2L2, GLRX3, NEK6, MORF4L1, PNKP, SNW1, ISCU, LSM4, FAM50B, ZNF581, SYT17, C1orf109, C19orf66, LMO3, CBX8, SH2D4A, KIF9, GMCL1P1, AEN, C8orf33, SCNM1, NOC4L, ARMC7, FAM214B, FAM161A, SPATC1L, FRMD6, ZNF417, ZMAT2, ALKBH3, CEP57L1, C1orf174, FAM74A4, SH3BP2, MPPED2, NFATC2, NFATC1, MIB2, KLHDC10, POC1A, FOXK2, FOXK1, WDR76, APPBP2, ANKRD27, ZMYND19, KLHDC3, NFS1, MTA3, CUL2, BTBD1, HSD17B4, WDR26, GATAD2A, MKLN1, GATAD2B, RMND5A, RANBP10, MTA2, ARMC8, GALC, POTEI


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC61G_IKZF1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC61G_IKZF1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneIKZF1C0009324Ulcerative Colitis1CTD_human
TgeneIKZF1C0023485Precursor B-Cell Lymphoblastic Leukemia-Lymphoma1CTD_human
TgeneIKZF1C0024141Lupus Erythematosus, Systemic1CTD_human
TgeneIKZF1C0024299Lymphoma1CTD_human
TgeneIKZF1C1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human
TgeneIKZF1C4225173IMMUNODEFICIENCY, COMMON VARIABLE, 131ORPHANET;UNIPROT