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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33069

FusionGeneSummary for SEC31A_MEMO1

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC31A_MEMO1
Fusion gene ID: 33069
HgeneTgene
Gene symbol

SEC31A

MEMO1

Gene ID

22872

51072

Gene nameSEC31 homolog A, COPII coat complex componentmediator of cell motility 1
SynonymsABP125|ABP130|HSPC275|HSPC334|SEC31L1C2orf4|CGI-27|MEMO|NS5ATP7
Cytomap

4q21.22

2p22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec31ASEC31 homolog A, COPII coating complex componentSEC31-like protein 1SEC31-related protein Aweb1-like proteinyeast Sec31p homologprotein MEMO1C21orf19-like proteinHCV NS5A-transactivated protein 7hepatitis C virus NS5A-transactivated protein 7mediator of ErbB2-driven cell motility 1
Modification date2018052320180523
UniProtAcc

O94979

Q9Y316

Ensembl transtripts involved in fusion geneENST00000348405, ENST00000513858, 
ENST00000395310, ENST00000443462, 
ENST00000509142, ENST00000326950, 
ENST00000432794, ENST00000311785, 
ENST00000448323, ENST00000505472, 
ENST00000500777, ENST00000508502, 
ENST00000355196, ENST00000264405, 
ENST00000505984, ENST00000508479, 
ENST00000436790, 		ENST00000295065, 
ENST00000379383, ENST00000404530, 
ENST00000490459, ENST00000426310, 
ENST00000407893, 
Fusion gene scores* DoF score15 X 14 X 8=16806 X 6 X 2=72
# samples 186
** MAII scorelog2(18/1680*10)=-3.22239242133645
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC31A [Title/Abstract] AND MEMO1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC31A

GO:0051592

response to calcium ion

17196169

HgeneSEC31A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF751621SEC31Achr4

83819174

-MEMO1chr2

32094983

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000348405ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000348405ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000348405ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000348405ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000348405ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000348405ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000513858ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000513858ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000513858ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000513858ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000513858ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000513858ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000395310ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000395310ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000395310ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000395310ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000395310ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000395310ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000443462ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000443462ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000443462ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000443462ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000443462ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000443462ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000509142ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000509142ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000509142ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000509142ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000509142ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000509142ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000326950ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000326950ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000326950ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000326950ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000326950ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000326950ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000432794ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000432794ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000432794ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000432794ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000432794ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000432794ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000311785ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000311785ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000311785ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000311785ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000311785ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000311785ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000448323ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000448323ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000448323ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000448323ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000448323ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000448323ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505472ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505472ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505472ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000505472ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000505472ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000505472ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000500777ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000500777ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000500777ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000500777ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000500777ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000500777ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508502ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508502ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508502ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000508502ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000508502ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000508502ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000355196ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000355196ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000355196ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000355196ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000355196ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000355196ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000264405ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000264405ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000264405ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000264405ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000264405ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000264405ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505984ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505984ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000505984ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000505984ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000505984ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000505984ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508479ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508479ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000508479ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000508479ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000508479ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000508479ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000436790ENST00000295065SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000436790ENST00000379383SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-3CDSENST00000436790ENST00000404530SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000436790ENST00000490459SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-5UTRENST00000436790ENST00000426310SEC31Achr4

83819174

-MEMO1chr2

32094983

+
intron-intronENST00000436790ENST00000407893SEC31Achr4

83819174

-MEMO1chr2

32094983

+

Top

FusionProtFeatures for SEC31A_MEMO1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC31A

O94979

MEMO1

Q9Y316

May control cell migration by relaying extracellularchemotactic signals to the microtubule cytoskeleton. Mediator ofERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays animportant role in ERBB2-dependent stabilization of microtubules atthe cell cortex. It controls the localization of APC and CLASP2 tothe cell membrane, via the regulation of GSK3B activity. In turn,membrane-bound APC allows the localization of the MACF1 to thecell membrane, which is required for microtubule capture andstabilization. Is required for breast carcinoma cell migration.{ECO:0000269|PubMed:15156151, ECO:0000269|PubMed:20937854}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC31A_MEMO1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC31A_MEMO1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SEC31A_MEMO1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

RelatedDiseases for SEC31A_MEMO1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC31AC0079744Diffuse Large B-Cell Lymphoma1CTD_human