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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33055

FusionGeneSummary for SEC24C_CCT5

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC24C_CCT5
Fusion gene ID: 33055
HgeneTgene
Gene symbol

SEC24C

CCT5

Gene ID

9632

22948

Gene nameSEC24 homolog C, COPII coat complex componentchaperonin containing TCP1 subunit 5
Synonyms-CCT-epsilon|CCTE|HEL-S-69|PNAS-102|TCP-1-epsilon
Cytomap

10q22.2

5p15.2

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec24CSEC24 family, member CSEC24 related gene family, member CSEC24-related protein CT-complex protein 1 subunit epsilonchaperonin containing TCP1, subunit 5 (epsilon)epididymis secretory protein Li 69
Modification date2018052220180523
UniProtAcc

P53992

P48643

Ensembl transtripts involved in fusion geneENST00000535742, ENST00000546025, 
ENST00000345254, ENST00000540668, 
ENST00000339365, ENST00000411652, 
ENST00000496827, 		ENST00000280326, 
ENST00000503026, ENST00000515390, 
ENST00000515676, ENST00000506600, 
Fusion gene scores* DoF score3 X 3 X 3=2749 X 6 X 16=4704
# samples 353
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(53/4704*10)=-3.1498237953858
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC24C [Title/Abstract] AND CCT5 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC24C

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCESCTCGA-JW-A5VI-01ASEC24Cchr10

75531919

+CCT5chr5

10250033

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000535742ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000535742ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000535742ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000535742ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000535742ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-3CDSENST00000546025ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000546025ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000546025ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000546025ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000546025ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
Frame-shiftENST00000345254ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000345254ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000345254ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000345254ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000345254ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-3CDSENST00000540668ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000540668ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000540668ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000540668ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000540668ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
Frame-shiftENST00000339365ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000339365ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000339365ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000339365ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
5CDS-intronENST00000339365ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-3CDSENST00000411652ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000411652ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000411652ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000411652ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000411652ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-3CDSENST00000496827ENST00000280326SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000496827ENST00000503026SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000496827ENST00000515390SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000496827ENST00000515676SEC24Cchr10

75531919

+CCT5chr5

10250033

+
intron-intronENST00000496827ENST00000506600SEC24Cchr10

75531919

+CCT5chr5

10250033

+

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FusionProtFeatures for SEC24C_CCT5


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC24C

P53992

CCT5

P48643

Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex (PubMed:10214955, PubMed:17499046, PubMed:18843296,PubMed:20427317). Plays a central role in cargo selection withinthe COPII complex and together with SEC24D may have a differentspecificity compared to SEC24A and SEC24B (PubMed:17499046,PubMed:20427317, PubMed:18843296). May more specifically packageGPI-anchored proteins through the cargo receptor TMED10(PubMed:20427317). May also be specific for IxM motif-containingcargos like the SNAREs GOSR2 and STX5 (PubMed:18843296).{ECO:0000269|PubMed:10214955, ECO:0000269|PubMed:17499046,ECO:0000269|PubMed:18843296, ECO:0000269|PubMed:20427317}. Molecular chaperone; assists the folding of proteinsupon ATP hydrolysis. As part of the BBS/CCT complex may play arole in the assembly of BBSome, a complex involved in ciliogenesisregulating transports vesicles to the cilia. Known to play a role,in vitro, in the folding of actin and tubulin.{ECO:0000269|PubMed:20080638}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC24C_CCT5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC24C_CCT5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC24CSEC23B, SEC23A, SIRT7, SPP1, CUL3, CAND1, APP, SEC24D, SEC24A, DTNA, AHCYL1, HSPA8, SNRPF, NDUFS1, CPLX1, CLNS1A, COG3, USP9X, PSMA5, COPA, PICALM, ZFYVE19, NOTCH2, MED15, SERPINH1, PSMD1, PPIL3, FN1, TP63, ITGA4, FBXO7, ATP6V1B2, CSDE1, OTUD6B, SBNO1, AP2B1, CRMP1, PBDC1, GMPR2, PARVA, SUPT5H, XPO7, ZYX, SSRP1, WWOX, MOS, WIPF1, MOV10, NXF1, OBSL1, CD2AP, SH3KBP1, NTRK1, EWSR1, CNTRL, STIL, XPO1, CDC42, CLTC, GAK, SEC16A, GTSE1, CENPQ, CDC5L, G3BP1, BRCA1CCT5XRN1, THEG, SSSCA1, HDAC3, ACTB, TBC1D17, IKBKAP, IMMT, TP53, PPP4C, CTTNBP2, MOB4, PPP2CA, STK24, STRN, STRN3, TRAF3IP3, PPP2CB, PPP2R2C, IGBP1, TCP1, ACTA2, ACTA1, GPN1, HNRNPH1, RPAP2, RPAP3, CDK9, RFWD2, SRRM2, SRRM1, WDR82, H2AFX, UBC, MYC, PPP2R2A, PPP2R2B, PPP2R2D, PPP2R4, AGO4, HDAC5, PCK1, VHL, SIRT7, FBXO25, CUL3, CUL4A, CDK2, GNB5, GNB1, RGS7, PDCL, GRB2, PACRG, CCT2, CCT3, CCT8, CCT6A, CCT4, CCT7, CCT6B, AHCYL1, IARS, TARS, PSMA6, PSMB1, VCP, SSR1, XPO1, SLU7, TXNL1, SRSF2, ATXN2, TRIM28, FN1, VCAM1, ATF2, PEX14, NOS2, FAM86B2, METTL21B, ITGA4, PAN2, HDAC6, FBXW4, TERT, FBXO6, CDK5, ILK, CDC20, LGALS3BP, NEDD1, TUBG1, HUWE1, FUS, CUL7, OBSL1, RNF2, SIRT6, IKBKE, IRAK1, SGK2, TSSK6, TYK2, WDR76, POC1A, PEX7, RPS6KB2, DCAF7, UNK, ACTR2, AHNAK, HSPE1, PIN4, STUB1, NTRK1, BTRC, B9D1, MKS1, CETN2, CDK1, DDB2, HDAC1, PDK3, NSMAF, NIPSNAP1, PRPF4, BUB3, WRAP53, RFWD3, KIF21A, SEH1L, KBTBD7, TUBA1C, ARMC6, GAN, CRY2, ALKBH3, MCM2, SNW1, CDC5L, TTC27, NLE1, CDC73, CRBN, PPM1J, KLHDC8A, DNAI2, HCFC2, WDR77, DCAF11, KDM4B, KLHL33, KLHDC2, TXNDC9, WDR86, TBL1Y, DCAF8, THOC3, WDTC1, GANAB, ODF1, DCAF5, SEC31B, TSSC1, WDR83, CYLD, WDR92, TRIM25, MCPH1, HEY1, BRCA1, YAP1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC24C_CCT5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC24C_CCT5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC24CC0005586Bipolar Disorder1PSYGENET
HgeneSEC24CC0041696Unipolar Depression1PSYGENET
HgeneSEC24CC1269683Major Depressive Disorder1PSYGENET
TgeneCCT5C0019693HIV Infections1CTD_human
TgeneCCT5C1458155Mammary Neoplasms1CTD_human
TgeneCCT5C1850395Neuropathy, Hereditary Sensory, with Spastic Paraplegia, Autosomal Recessive1CTD_human;ORPHANET;UNIPROT