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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33042

FusionGeneSummary for SEC23B_SEC23B

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC23B_SEC23B
Fusion gene ID: 33042
HgeneTgene
Gene symbol

SEC23B

SEC23B

Gene ID

10483

10483

Gene nameSec23 homolog B, coat complex II componentSec23 homolog B, coat complex II component
SynonymsCDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23BCDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23B
Cytomap

20p11.23

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23Bprotein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23B
Modification date2018052320180523
UniProtAcc

Q15437

Q15437

Ensembl transtripts involved in fusion geneENST00000262544, ENST00000336714, 
ENST00000377475, ENST00000377465, 
ENST00000494645, 
ENST00000262544, 
ENST00000336714, ENST00000377475, 
ENST00000377465, ENST00000494645, 
Fusion gene scores* DoF score8 X 7 X 8=4484 X 5 X 3=60
# samples 108
** MAII scorelog2(10/448*10)=-2.16349873228288
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/60*10)=0.415037499278844
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC23B [Title/Abstract] AND SEC23B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AW361690SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
ChiTaRS3.1BG222141SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000262544ENST00000262544SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000262544ENST00000336714SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000262544ENST00000377475SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000262544ENST00000377465SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-intronENST00000262544ENST00000494645SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000336714ENST00000262544SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000336714ENST00000336714SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000336714ENST00000377475SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000336714ENST00000377465SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-intronENST00000336714ENST00000494645SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377475ENST00000262544SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377475ENST00000336714SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377475ENST00000377475SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377475ENST00000377465SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-intronENST00000377475ENST00000494645SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377465ENST00000262544SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377465ENST00000336714SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377465ENST00000377475SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000377465ENST00000377465SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-intronENST00000377465ENST00000494645SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000494645ENST00000262544SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000494645ENST00000336714SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000494645ENST00000377475SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-3CDSENST00000494645ENST00000377465SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
intron-intronENST00000494645ENST00000494645SEC23Bchr20

18506428

-SEC23Bchr20

18523009

-
Frame-shitENST00000262544ENST00000262544SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
Frame-shitENST00000262544ENST00000336714SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
Frame-shitENST00000262544ENST00000377475SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
Frame-shitENST00000262544ENST00000377465SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
5CDS-intronENST00000262544ENST00000494645SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000336714ENST00000262544SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000336714ENST00000336714SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000336714ENST00000377475SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000336714ENST00000377465SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
5CDS-intronENST00000336714ENST00000494645SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377475ENST00000262544SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377475ENST00000336714SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377475ENST00000377475SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377475ENST00000377465SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
5CDS-intronENST00000377475ENST00000494645SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377465ENST00000262544SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377465ENST00000336714SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377465ENST00000377475SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
In-frameENST00000377465ENST00000377465SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
5CDS-intronENST00000377465ENST00000494645SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
intron-3CDSENST00000494645ENST00000262544SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
intron-3CDSENST00000494645ENST00000336714SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
intron-3CDSENST00000494645ENST00000377475SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
intron-3CDSENST00000494645ENST00000377465SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-
intron-intronENST00000494645ENST00000494645SEC23Bchr20

18541377

+SEC23Bchr20

18535026

-

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FusionProtFeatures for SEC23B_SEC23B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC23B

Q15437

SEC23B

Q15437

Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000250|UniProtKB:Q15436}. Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000250|UniProtKB:Q15436}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC23B_SEC23B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC23B_SEC23B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC23B_SEC23B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC23B_SEC23B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC23BC1306589Congenital dyserythropoietic anemia, type II2ORPHANET;UNIPROT
HgeneSEC23BC0002876Congenital dyserythropoietic anemia1CTD_human
HgeneSEC23BC4225179COWDEN SYNDROME 71UNIPROT
TgeneSEC23BC1306589Congenital dyserythropoietic anemia, type II2ORPHANET;UNIPROT
TgeneSEC23BC0002876Congenital dyserythropoietic anemia1CTD_human
TgeneSEC23BC4225179COWDEN SYNDROME 71UNIPROT