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Fusion gene ID: 33040 |
FusionGeneSummary for SEC23B_NAPB |
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Fusion gene information | Fusion gene name: SEC23B_NAPB | Fusion gene ID: 33040 | Hgene | Tgene | Gene symbol | SEC23B | NAPB | Gene ID | 10483 | 63908 |
Gene name | Sec23 homolog B, coat complex II component | NSF attachment protein beta | |
Synonyms | CDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23B | SNAP-BETA|SNAPB | |
Cytomap | 20p11.23 | 20p11.21 | |
Type of gene | protein-coding | protein-coding | |
Description | protein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23B | beta-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, beta | |
Modification date | 20180523 | 20180523 | |
UniProtAcc | Q15437 | Q9H115 | |
Ensembl transtripts involved in fusion gene | ENST00000262544, ENST00000336714, ENST00000377475, ENST00000377465, ENST00000494645, | ENST00000377026, ENST00000398425, ENST00000432543, ENST00000472855, | |
Fusion gene scores | * DoF score | 8 X 7 X 8=448 | 2 X 1 X 2=4 |
# samples | 10 | 2 | |
** MAII score | log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
Context | PubMed: SEC23B [Title/Abstract] AND NAPB [Title/Abstract] AND fusion [Title/Abstract] | ||
Functional or gene categories assigned by FusionGDB annotation |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
![]() (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
TCGA | RV | SARC | TCGA-DX-A6YZ-01A | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
* LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3CDS | ENST00000262544 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-3CDS | ENST00000262544 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-3CDS | ENST00000262544 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-5UTR | ENST00000262544 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000336714 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000336714 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000336714 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-5UTR | ENST00000336714 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-3CDS | ENST00000377475 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-3CDS | ENST00000377475 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-3CDS | ENST00000377475 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
5UTR-5UTR | ENST00000377475 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000377465 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000377465 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000377465 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-5UTR | ENST00000377465 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000494645 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000494645 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-3CDS | ENST00000494645 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
intron-5UTR | ENST00000494645 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
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FusionProtFeatures for SEC23B_NAPB |
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Hgene | Tgene |
SEC23B | NAPB |
Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000250|UniProtKB:Q15436}. | Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus. {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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FusionGeneSequence for SEC23B_NAPB |
![]() (nt: nucleotides, aa: amino acids) |
* Fusion amino acid sequences. |
* Fusion transcript sequences (only coding sequence (CDS) region). |
* Fusion transcript sequences (Full-length transcript). |
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FusionGenePPI for SEC23B_NAPB |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
SEC23B | SEC24C, SEC24D, FYCO1, SIRT7, SYK, CUL3, CAND1, SEC24B, SRSF3, FN1, DAB2, TMED9, TMED10, TMED1, TMED2, KDELR1, UGT1A1, GALNT1, MAN2A1, SRPK2, SRPK1, PXN, ZYX, CSNK1A1, HOXA3, SEC23B, CPSF7, FATE1, DTX2, PRRC1, SYNE4, SLC25A35, KCNJ10, CPNE2, SEC13, DCUN1D1, SEC23A, SEC31A, SUMO2, SUMO3, SEC24A, NTRK1, STIL, TMEM17, TMEM216, CENPJ, XPO1, SEC16A, MCM2, NF2, SNW1, ATOH1, KIAA0226L, TRIM25, BRCA1 | NAPB | ELAVL1, TAF1B, STX1A, STX3, STX4, STX5, STX16, SNAP23, STX6, TFEC, ARL6IP1, STX12, HAX1, NUFIP1, DGUOK, DNAAF2, VAMP4 |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SEC23B_NAPB |
![]() (DrugBank Version 5.1.0 2018-04-02) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SEC23B_NAPB |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SEC23B | C1306589 | Congenital dyserythropoietic anemia, type II | 2 | ORPHANET;UNIPROT |
Hgene | SEC23B | C0002876 | Congenital dyserythropoietic anemia | 1 | CTD_human |
Hgene | SEC23B | C4225179 | COWDEN SYNDROME 7 | 1 | UNIPROT |