|
||||||
|
 | |
| |
| |
| |
| |
|
Fusion gene ID: 33040 |
FusionGeneSummary for SEC23B_NAPB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SEC23B_NAPB | Fusion gene ID: 33040 | Hgene | Tgene | Gene symbol | SEC23B | NAPB | Gene ID | 10483 | 63908 |
| Gene name | Sec23 homolog B, coat complex II component | NSF attachment protein beta | |
| Synonyms | CDA-II|CDAII|CDAN2|CWS7|HEMPAS|hSec23B | SNAP-BETA|SNAPB | |
| Cytomap | 20p11.23 | 20p11.21 | |
| Type of gene | protein-coding | protein-coding | |
| Description | protein transport protein Sec23BSEC23-like protein BSEC23-related protein BSec23 homolog B, COPII coat complex componenttransport protein SEC23B | beta-soluble NSF attachment proteinN-ethylmaleimide-sensitive factor attachment protein, beta | |
| Modification date | 20180523 | 20180523 | |
| UniProtAcc | Q15437 | Q9H115 | |
| Ensembl transtripts involved in fusion gene | ENST00000262544, ENST00000336714, ENST00000377475, ENST00000377465, ENST00000494645, | ENST00000377026, ENST00000398425, ENST00000432543, ENST00000472855, | |
| Fusion gene scores | * DoF score | 8 X 7 X 8=448 | 2 X 1 X 2=4 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/448*10)=-2.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/4*10)=2.32192809488736 | |
| Context | PubMed: SEC23B [Title/Abstract] AND NAPB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | SARC | TCGA-DX-A6YZ-01A | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 5UTR-3CDS | ENST00000262544 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-3CDS | ENST00000262544 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-3CDS | ENST00000262544 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-5UTR | ENST00000262544 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000336714 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000336714 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000336714 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-5UTR | ENST00000336714 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-3CDS | ENST00000377475 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-3CDS | ENST00000377475 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-3CDS | ENST00000377475 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| 5UTR-5UTR | ENST00000377475 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000377465 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000377465 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000377465 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-5UTR | ENST00000377465 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000494645 | ENST00000377026 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000494645 | ENST00000398425 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-3CDS | ENST00000494645 | ENST00000432543 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
| intron-5UTR | ENST00000494645 | ENST00000472855 | SEC23B | chr20 | 18488634 | + | NAPB | chr20 | 23361954 | - |
Top |
FusionProtFeatures for SEC23B_NAPB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SEC23B | NAPB |
| Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000250|UniProtKB:Q15436}. | Required for vesicular transport between the endoplasmicreticulum and the Golgi apparatus. {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Top |
FusionGeneSequence for SEC23B_NAPB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| * Fusion transcript sequences (Full-length transcript). |
Top |
FusionGenePPI for SEC23B_NAPB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SEC23B | SEC24C, SEC24D, FYCO1, SIRT7, SYK, CUL3, CAND1, SEC24B, SRSF3, FN1, DAB2, TMED9, TMED10, TMED1, TMED2, KDELR1, UGT1A1, GALNT1, MAN2A1, SRPK2, SRPK1, PXN, ZYX, CSNK1A1, HOXA3, SEC23B, CPSF7, FATE1, DTX2, PRRC1, SYNE4, SLC25A35, KCNJ10, CPNE2, SEC13, DCUN1D1, SEC23A, SEC31A, SUMO2, SUMO3, SEC24A, NTRK1, STIL, TMEM17, TMEM216, CENPJ, XPO1, SEC16A, MCM2, NF2, SNW1, ATOH1, KIAA0226L, TRIM25, BRCA1 | NAPB | ELAVL1, TAF1B, STX1A, STX3, STX4, STX5, STX16, SNAP23, STX6, TFEC, ARL6IP1, STX12, HAX1, NUFIP1, DGUOK, DNAAF2, VAMP4 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
RelatedDrugs for SEC23B_NAPB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Top |
RelatedDiseases for SEC23B_NAPB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SEC23B | C1306589 | Congenital dyserythropoietic anemia, type II | 2 | ORPHANET;UNIPROT |
| Hgene | SEC23B | C0002876 | Congenital dyserythropoietic anemia | 1 | CTD_human |
| Hgene | SEC23B | C4225179 | COWDEN SYNDROME 7 | 1 | UNIPROT |
Copyright 2018-Present -The University of Texas Health Science Center at Houston (UTHealth)
|