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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33030

FusionGeneSummary for SEC23A_NUP107

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC23A_NUP107
Fusion gene ID: 33030
HgeneTgene
Gene symbol

SEC23A

NUP107

Gene ID

10484

57122

Gene nameSec23 homolog A, coat complex II componentnucleoporin 107
SynonymsCLSD|hSec23ANPHS11|NUP84
Cytomap

14q21.1

12q15

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec23ASEC23-related protein ASec23 homolog A, COPII coat complex componentnuclear pore complex protein Nup107nucleoporin 107kDa
Modification date2018052320180523
UniProtAcc

Q15436

P57740

Ensembl transtripts involved in fusion geneENST00000537403, ENST00000307712, 
ENST00000536508, ENST00000545328, 
ENST00000553925, ENST00000548032, 
ENST00000557280, ENST00000553970, 
ENST00000229179, ENST00000378905, 
ENST00000539906, ENST00000401003, 
Fusion gene scores* DoF score8 X 9 X 3=21623 X 12 X 9=2484
# samples 926
** MAII scorelog2(9/216*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(26/2484*10)=-3.25608164519203
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC23A [Title/Abstract] AND NUP107 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC23A

GO:0090110

cargo loading into COPII-coated vesicle

17499046|18843296

TgeneNUP107

GO:0006406

mRNA export from nucleus

11684705


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AI445956SEC23Achr14

39560265

-NUP107chr12

69083966

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000537403ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000537403ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000537403ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000537403ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000307712ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000307712ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000307712ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000307712ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000536508ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000536508ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000536508ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000536508ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000545328ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000545328ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000545328ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000545328ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553925ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553925ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553925ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553925ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000548032ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000548032ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000548032ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000548032ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000557280ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000557280ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000557280ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000557280ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553970ENST00000229179SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553970ENST00000378905SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553970ENST00000539906SEC23Achr14

39560265

-NUP107chr12

69083966

-
intron-intronENST00000553970ENST00000401003SEC23Achr14

39560265

-NUP107chr12

69083966

-

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FusionProtFeatures for SEC23A_NUP107


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC23A

Q15436

NUP107

P57740

Component of the coat protein complex II (COPII) whichpromotes the formation of transport vesicles from the endoplasmicreticulum (ER). The coat has two main functions, the physicaldeformation of the endoplasmic reticulum membrane into vesiclesand the selection of cargo molecules for their transport to theGolgi complex. {ECO:0000269|PubMed:16980979,ECO:0000269|PubMed:17499046, ECO:0000269|PubMed:18843296,ECO:0000269|PubMed:27551091, ECO:0000269|PubMed:8898360}. Plays a role in the nuclear pore complex (NPC) assemblyand/or maintenance (PubMed:12552102, PubMed:15229283). Requiredfor the assembly of peripheral proteins into the NPC(PubMed:15229283, PubMed:12552102). May anchor NUP62 to the NPC(PubMed:15229283). {ECO:0000269|PubMed:12552102,ECO:0000269|PubMed:15229283}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC23A_NUP107


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC23A_NUP107


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC23A_NUP107


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC23A_NUP107


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSEC23AC0029408Degenerative polyarthritis1CTD_human
HgeneSEC23AC1843042Craniolenticulosutural Dysplasia1CTD_human;ORPHANET;UNIPROT
TgeneNUP107C4225228NEPHROTIC SYNDROME, TYPE 111UNIPROT