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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33024

FusionGeneSummary for SEC22B_ACOT11

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC22B_ACOT11
Fusion gene ID: 33024
HgeneTgene
Gene symbol

SEC22B

ACOT11

Gene ID

9554

26027

Gene nameSEC22 homolog B, vesicle trafficking protein (gene/pseudogene)acyl-CoA thioesterase 11
SynonymsERS-24|SEC22L1BFIT|STARD14|THEA|THEM1
Cytomap

1p12

1p32.3

Type of geneprotein-codingprotein-coding
Descriptionvesicle-trafficking protein SEC22bER-Golgi SNARE of 24 kDaSEC22 vesicle trafficking protein homolog BSEC22 vesicle trafficking protein-like 1acyl-coenzyme A thioesterase 11START domain containing 14StAR-related lipid transfer (START) domain containing 14acyl-CoA thioester hydrolase 11adipose-associated thioesterasebrown fat-inducible thioesterasethioesterase superfamily member 1thioeste
Modification date2018052320180523
UniProtAcc

Q8WXI4

Ensembl transtripts involved in fusion geneENST00000453618, ENST00000481208, 
ENST00000343744, ENST00000371316, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 2=18
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SEC22B [Title/Abstract] AND ACOT11 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-E9-A1R7-01ASEC22Bchr1

145104017

-ACOT11chr1

55062932

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3UTRENST00000453618ENST00000481208SEC22Bchr1

145104017

-ACOT11chr1

55062932

+
3UTR-3UTRENST00000453618ENST00000343744SEC22Bchr1

145104017

-ACOT11chr1

55062932

+
3UTR-3UTRENST00000453618ENST00000371316SEC22Bchr1

145104017

-ACOT11chr1

55062932

+

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FusionProtFeatures for SEC22B_ACOT11


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC22B

ACOT11

Q8WXI4

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Has acyl-CoA thioesterase activity towards medium (C12)and long-chain (C18) fatty acyl-CoA substrates.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC22B_ACOT11


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC22B_ACOT11


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC22BSTX18, STX5, GOSR1, ELAVL1, S100A16, TMED10, SEPT11, TST, TCOF1, UBE2M, STIM1, TMED9, SUCLA2, ZYX, SMARCA2, SEPT9, VAMP2, SART1, UBXN1, MPST, SERPINH1, CPS1, TMEM189, XRCC1, VAPB, TMEM9, SUCLG2, SIN3A, TACO1, VPS29, TIMM9, VCP, FN1, UBL4A, ADRB2, ATP4A, B3GAT3, RPA1, RPA2, RPA3, CUL7, OBSL1, CCDC8, RNF2, DERL1, UBAC2, STX1A, TCTN2, TCTN3, TMEM17, TMEM216, CREB3, ATP6AP2, ATL3, GOLT1B, CENPO, MCM2, USE1, SCFD2, NBAS, RINT1, BNIP1, BET1, GOSR2, KIAA1033, STX8, NAPA, UGT8, SNAP47, VTI1B, NAPG, C19orf25, ZW10, STX7, STX6, KIAA1467, SCFD1, STX10, STX12, SLC39A3, PDHA1, SDHA, TRIM25, LMNAACOT11ACOT11, THUMPD3, TEKT2, ACOT12


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC22B_ACOT11


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC22B_ACOT11


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource