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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33020

FusionGeneSummary for SEC16A_ZNF133

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC16A_ZNF133
Fusion gene ID: 33020
HgeneTgene
Gene symbol

SEC16A

ZNF133

Gene ID

9919

7692

Gene nameSEC16 homolog A, endoplasmic reticulum export factorzinc finger protein 133
SynonymsKIAA0310|SEC16L|p250ZNF150|pHZ-13|pHZ-66
Cytomap

9q34.3

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionprotein transport protein Sec16Aprotein SEC16 homolog Azinc finger protein 133zinc finger protein 133 (clone pHZ-13)zinc finger protein 150 (pHZ-66)
Modification date2018052320180523
UniProtAcc

O15027

P52736

Ensembl transtripts involved in fusion geneENST00000313050, ENST00000467838, 
ENST00000371706, ENST00000313084, 
ENST00000290037, ENST00000431893, 
ENST00000398335, 
ENST00000377671, 
ENST00000396026, ENST00000402618, 
ENST00000401790, ENST00000538547, 
ENST00000535822, ENST00000316358, 
ENST00000462170, 
Fusion gene scores* DoF score7 X 5 X 6=2102 X 2 X 2=8
# samples 82
** MAII scorelog2(8/210*10)=-1.39231742277876
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: SEC16A [Title/Abstract] AND ZNF133 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC16A

GO:0007029

endoplasmic reticulum organization

21768384


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUADTCGA-44-7671-01ASEC16Achr9

139334553

-ZNF133chr20

18278933

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000313050ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313050ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-5UTRENST00000467838ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000467838ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-5UTRENST00000371706ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000371706ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-5UTRENST00000313084ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
5CDS-intronENST00000313084ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-5UTRENST00000290037ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000290037ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-5UTRENST00000431893ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000431893ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-5UTRENST00000398335ENST00000377671SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000396026SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000402618SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000401790SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000538547SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000535822SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000316358SEC16Achr9

139334553

-ZNF133chr20

18278933

+
intron-intronENST00000398335ENST00000462170SEC16Achr9

139334553

-ZNF133chr20

18278933

+

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FusionProtFeatures for SEC16A_ZNF133


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC16A

O15027

ZNF133

P52736

Defines endoplasmic reticulum exit sites (ERES) and isrequired for secretory cargo traffic from the endoplasmicreticulum to the Golgi apparatus. SAR1A-GTP-dependent assembly ofSEC16A on the ER membrane forms an organized scaffold defining anERES. Required for normal transitional endoplasmic reticulum (tER)organization. {ECO:0000269|PubMed:17005010,ECO:0000269|PubMed:17192411}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC16A_ZNF133


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC16A_ZNF133


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC16ANFKB2, TERF1, TERF2, SIRT7, TSG101, CUL3, CAND1, SHC1, VCP, IQCB1, TRAF3, USO1, TRAF2, PAN2, SOX2, HDAC6, HDAC8, HDAC11, ANKRD28, LATS1, LATS2, SAV1, FKBP3, KRT18, CSNK1A1, CSNK1E, CEP250, EMD, CCDC8, RNF2, IRAK1, KLK15, AHNAK, HNRNPH3, NTRK1, MED23, CENPJ, XPO1, AP2A1, C4BPA, CAD, CLTA, CLTB, CLTC, DCTN1, DSP, ERF, GAK, GOLGA2, HNRNPA1, HNRNPK, IMPDH1, IMPDH2, HNRNPM, PFDN2, PIK3C2A, PKP2, PRKAR2A, RBM4, ATXN2, SEC13, TRPS1, VCL, ZKSCAN1, CLTCL1, TNK1, HDAC3, FUBP3, P4HA2, MAP7, BAG3, RBM39, NCOR2, SEC24C, CLINT1, PUM1, SMG7, CAPZA2, CDK2, DBN1, MYH9, PPP1CB, PRKAR2B, PICALM, IQGAP1, SYNPO, MAPRE1, TRIM29, LIMA1, GTSE1, MYO19, CDKN2AIPNL, ELMSAN1, ARX, FAM83H, MYO18A, HELZ, SEC24B, RBM14, SEC23B, SEC23A, SEC24A, PPP1R13L, PKP3, BTBD3, SPG20, FAM120A, KANK2, AKAP8L, PLEKHA5, ANKHD1, FAM120C, PIH1D1, WDR33, BMP2K, KIAA1217, EIF4ENIF1, CCAR2, P3H1, CPSF7, FIP1L1, FAM83D, CHD6, PRRC2B, FAM83A, WDR92, HNRNPUL2, FAM83B, CRY2, MCM2, RC3H1, MYO6, EGFR, EYA2, NEFL, XPNPEP3, AIPL1, PDHA1, BRCA1, YAP1, TESZNF133ILK, PDPK1, MAPK6, TRIM28, FOS, MDM2, KRTAP10-7, MRS2, RPS27A, SAV1, STK3, TRIM24, MRPS7, STK4, DAP3, CLPP, MRPS2, FTL, MRPS23, TPD52


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

RelatedDrugs for SEC16A_ZNF133


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC16A_ZNF133


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource