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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33012

FusionGeneSummary for SEC14L5_MBP

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC14L5_MBP
Fusion gene ID: 33012
HgeneTgene
Gene symbol

SEC14L5

MBP

Gene ID

9717

5553

Gene nameSEC14 like lipid binding 5proteoglycan 2, pro eosinophil major basic protein
SynonymsPRELID4BBMPG|MBP|MBP1|proMBP
Cytomap

16p13.3

11q12.1

Type of geneprotein-codingprotein-coding
DescriptionSEC14-like protein 5SEC14-like 5bone marrow proteoglycaneosinophil granule major basic proteineosinophil major basic proteinnatural killer cell activatorproteoglycan 2 preproproteinproteoglycan 2, bone marrow (natural killer cell activator, eosinophil granule major basic protein)
Modification date2018051920180519
UniProtAcc

O43304

P02686

Ensembl transtripts involved in fusion geneENST00000251170, ENST00000382582, 
ENST00000355994, ENST00000397875, 
ENST00000397866, ENST00000397865, 
ENST00000527041, ENST00000359645, 
ENST00000528160, ENST00000397869, 
ENST00000354542, ENST00000526111, 
ENST00000580402, ENST00000579129, 
ENST00000578193, ENST00000397863, 
ENST00000397860, ENST00000487778, 
Fusion gene scores* DoF score1 X 1 X 1=126 X 20 X 3=1560
# samples 127
** MAII scorelog2(1/1*10)=3.32192809488736log2(27/1560*10)=-2.53051471669878
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC14L5 [Title/Abstract] AND MBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BF933809SEC14L5chr16

5061729

-MBPchr18

74702956

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000251170ENST00000382582SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000355994SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397875SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397866SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397865SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000527041SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000359645SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000528160SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397869SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000354542SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000526111SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000580402SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000579129SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000578193SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397863SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000397860SEC14L5chr16

5061729

-MBPchr18

74702956

-
intron-intronENST00000251170ENST00000487778SEC14L5chr16

5061729

-MBPchr18

74702956

-

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FusionProtFeatures for SEC14L5_MBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC14L5

O43304

MBP

P02686


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC14L5_MBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC14L5_MBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC14L5_MBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC14L5_MBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMBPC0036341Schizophrenia4PSYGENET
TgeneMBPC0014072Experimental Autoimmune Encephalomyelitis3CTD_human
TgeneMBPC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneMBPC0011303Demyelinating Diseases1CTD_human
TgeneMBPC0027873Neuromyelitis Optica1CTD_human