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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 33006

FusionGeneSummary for SEC14L1_SPOP

check button Fusion gene summary
Fusion gene informationFusion gene name: SEC14L1_SPOP
Fusion gene ID: 33006
HgeneTgene
Gene symbol

SEC14L1

SPOP

Gene ID

6397

8405

Gene nameSEC14 like lipid binding 1speckle type BTB/POZ protein
SynonymsPRELID4A|SEC14LBTBD32|TEF2
Cytomap

17q25.2-q25.3

17q21.33

Type of geneprotein-codingprotein-coding
DescriptionSEC14-like protein 1speckle-type POZ proteinHIB homolog 1roadkill homolog 1
Modification date2018051920180523
UniProtAcc

Q92503

O43791

Ensembl transtripts involved in fusion geneENST00000392476, ENST00000430767, 
ENST00000564509, ENST00000585618, 
ENST00000413679, ENST00000436233, 
ENST00000443798, ENST00000591437, 
ENST00000431431, 		ENST00000393328, 
ENST00000393331, ENST00000347630, 
ENST00000504102, ENST00000503676, 
ENST00000513080, 
Fusion gene scores* DoF score5 X 3 X 5=759 X 4 X 5=180
# samples 58
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(8/180*10)=-1.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SEC14L1 [Title/Abstract] AND SPOP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSEC14L1

GO:0015871

choline transport

17092608


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2783-01ASEC14L1chr17

75089429

+SPOPchr17

47700238

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-5UTRENST00000392476ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000392476ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000392476ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000392476ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000392476ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000392476ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
5UTR-5UTRENST00000430767ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
3UTR-5UTRENST00000564509ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000585618ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000413679ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000436233ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000443798ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000591437ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000393328SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000393331SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000347630SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000504102SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000503676SEC14L1chr17

75089429

+SPOPchr17

47700238

-
intron-5UTRENST00000431431ENST00000513080SEC14L1chr17

75089429

+SPOPchr17

47700238

-

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FusionProtFeatures for SEC14L1_SPOP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SEC14L1

Q92503

SPOP

O43791

May play a role in innate immunity by inhibiting theantiviral RIG-I signaling pathway. In this pathway, functions as anegative regulator of DDX58/RIG-I, the cytoplasmic sensor of viralnucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1,an important step in signal propagation (PubMed:23843640). Mayalso regulate the SLC18A3 and SLC5A7 cholinergic transporters(PubMed:17092608). {ECO:0000269|PubMed:17092608,ECO:0000269|PubMed:23843640}. Component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3ubiquitin-protein ligase complex that mediates the ubiquitinationof target proteins, leading most often to their proteasomaldegradation. In complex with CUL3, involved in ubiquitination andproteasomal degradation of BRMS1, DAXX, PDX1/IPF1, GLI2 and GLI3.In complex with CUL3, involved in ubiquitination of H2AFY andBMI1; this does not lead to their proteasomal degradation.Inhibits transcriptional activation of PDX1/IPF1 targets, such asinsulin, by promoting PDX1/IPF1 degradation. The cullin-RING-basedBCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex containinghomodimeric SPOP has higher ubiquitin ligase activity than thecomplex that contains the heterodimer formed by SPOP and SPOPL.{ECO:0000269|PubMed:14528312, ECO:0000269|PubMed:15897469,ECO:0000269|PubMed:16524876, ECO:0000269|PubMed:19818708,ECO:0000269|PubMed:22085717, ECO:0000269|PubMed:22632832}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SEC14L1_SPOP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SEC14L1_SPOP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SEC14L1KPTN, C2CD2, CCNDBP1, CDH13, NCR3LG1, CD70, LAMP3SPOPZBTB16, DPPA2, RXRB, DDIT3, RTN3, MYD88, SIRT2, DOK2, KPNA6, GDI1, PIP5K1B, TRAF1, TRAF6, AR, BMI1, NCOA3, CUL3, ESR1, DAXX, SPOP, PIP4K2B, UBE2E3, FADD, PIAS1, GIT2, SRRM1, ATM, GLI2, DEK, BRMS1, NUP50, RTN4, GCC1, ERG, ERF, PGR, GLI3, UBE2D1, UBE2D2, NANOG, PTEN, DUSP7, EGLN2, RFWD2, SOST, ARIH1, MSRB3, BRD4, BRD3, BRD2


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SEC14L1_SPOP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SEC14L1_SPOP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneSPOPC0014170Endometrial Neoplasms1CTD_human
TgeneSPOPC0033578Prostatic Neoplasms1CTD_human