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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32997

FusionGeneSummary for SDS_GNA14

check button Fusion gene summary
Fusion gene informationFusion gene name: SDS_GNA14
Fusion gene ID: 32997
HgeneTgene
Gene symbol

SDS

GNA14

Gene ID

51119

9630

Gene nameSBDS, ribosome maturation factorG protein subunit alpha 14
SynonymsCGI-97|SDS|SWDS-
Cytomap

7q11.21

9q21.2

Type of geneprotein-codingprotein-coding
Descriptionribosome maturation protein SBDSSBDS, ribosome assembly guanine nucleotide exchange factorguanine nucleotide-binding protein subunit alpha-14g alpha-14guanine nucleotide binding protein (G protein), alpha 14guanine nucleotide-binding protein 14
Modification date2018051920180523
UniProtAcc

P20132

O95837

Ensembl transtripts involved in fusion geneENST00000257549, ENST00000341700, 
ENST00000464095, 
Fusion gene scores* DoF score1 X 1 X 1=15 X 3 X 4=60
# samples 15
** MAII scorelog2(1/1*10)=3.32192809488736log2(5/60*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDS [Title/Abstract] AND GNA14 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSDS

GO:0007052

mitotic spindle organization

18324336

HgeneSDS

GO:0030595

leukocyte chemotaxis

14743349

HgeneSDS

GO:0042256

mature ribosome assembly

21536732


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AV645432SDSchr12

113830890

+GNA14chr9

80136692

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000257549ENST00000341700SDSchr12

113830890

+GNA14chr9

80136692

-
intron-intronENST00000257549ENST00000464095SDSchr12

113830890

+GNA14chr9

80136692

-

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FusionProtFeatures for SDS_GNA14


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDS

P20132

GNA14

O95837

Guanine nucleotide-binding proteins (G proteins) areinvolved as modulators or transducers in various transmembranesignaling systems.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDS_GNA14


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDS_GNA14


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDS_GNA14


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSDSP20132DB00114Pyridoxal PhosphateL-serine dehydratase/L-threonine deaminasesmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SDS_GNA14


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDSC0023893Liver Cirrhosis, Experimental1CTD_human
TgeneGNA14C0023893Liver Cirrhosis, Experimental1CTD_human