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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32978

FusionGeneSummary for SDHA_PLEKHG4B

check button Fusion gene summary
Fusion gene informationFusion gene name: SDHA_PLEKHG4B
Fusion gene ID: 32978
HgeneTgene
Gene symbol

SDHA

PLEKHG4B

Gene ID

6389

153478

Gene namesuccinate dehydrogenase complex flavoprotein subunit Apleckstrin homology and RhoGEF domain containing G4B
SynonymsCMD1GG|FP|PGL5|SDH1|SDH2|SDHF-
Cytomap

5p15.33

5p15.33

Type of geneprotein-codingprotein-coding
Descriptionsuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialflavoprotein subunit of complex IIsuccinate dehydrogenase complex, subunit A, flavoprotein (Fp)pleckstrin homology domain-containing family G member 4BPH domain-containing family G member 4Bpleckstrin homology domain containing, family G (with RhoGef domain) member 4B
Modification date2018052320180403
UniProtAcc

P31040

Q96PX9

Ensembl transtripts involved in fusion geneENST00000264932, ENST00000504309, 
ENST00000510361, ENST00000507522, 
ENST00000283426, 
Fusion gene scores* DoF score5 X 5 X 4=1007 X 4 X 6=168
# samples 57
** MAII scorelog2(5/100*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(7/168*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDHA [Title/Abstract] AND PLEKHG4B [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSDHA

GO:0006105

succinate metabolic process

7550341

HgeneSDHA

GO:0022904

respiratory electron transport chain

7550341

HgeneSDHA

GO:0055114

oxidation-reduction process

7550341


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDESCATCGA-LN-A5U6-01ASDHAchr5

233760

+PLEKHG4Bchr5

139598

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000264932ENST00000283426SDHAchr5

233760

+PLEKHG4Bchr5

139598

+
5CDS-intronENST00000504309ENST00000283426SDHAchr5

233760

+PLEKHG4Bchr5

139598

+
5CDS-intronENST00000510361ENST00000283426SDHAchr5

233760

+PLEKHG4Bchr5

139598

+
intron-intronENST00000507522ENST00000283426SDHAchr5

233760

+PLEKHG4Bchr5

139598

+

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FusionProtFeatures for SDHA_PLEKHG4B


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDHA

P31040

PLEKHG4B

Q96PX9

Flavoprotein (FP) subunit of succinate dehydrogenase(SDH) that is involved in complex II of the mitochondrial electrontransport chain and is responsible for transferring electrons fromsuccinate to ubiquinone (coenzyme Q) (PubMed:24781757). Can act asa tumor suppressor (PubMed:20484225).{ECO:0000269|PubMed:20484225, ECO:0000305|PubMed:24781757}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDHA_PLEKHG4B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDHA_PLEKHG4B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDHAUBC, ICT1, CSNK2B, ARRB2, SIRT7, CUL3, CUL4A, CUL5, CUL2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, SDHB, SUCLA2, SUCLG1, SUCLG2, UQCRFS1, UQCRB, SYNE2, MTERF3, RAVER1, TIMM50, LRRC8A, MDH1, SAMM50, DHODH, TOMM70A, TAP1, TMEM14B, HIGD1A, NDUFS2, OXCT1, MRPL1, MRPS9, ZC3H4, NDUFS3, CYB5R3, NDUFS6, NDUFS8, NDUFV2, EIF4A1, XRCC6, MARC1, IMPAD1, ACAT1, GCN1L1, PSMD1, PROCR, SLC2A14, SLC27A2, SQSTM1, PDHA1, ATP5F1, NDUFV1, FN1, ITGA4, FBXO6, NXF1, APOA1BP, ATP1B1, CPNE1, CPNE3, CYC1, DLD, DNAJA3, HSPA9, HSPB1, MDH2, MTCH1, NDUFA2, PPIB, RAB14, ACLY, CS, GLOD4, SDHC, UQCRQ, NTRK1, HSPB2, CEP128, RPGRIP1L, TMEM67, SDHAF2, CRY1, CRY2, UBXN10, OTUB1, NFATC2, DUSP4, DUSP9, C6orf57, PDZRN3, PDSS2, PDSS1, PDP1, ACN9, SIRT3, ACAD9, WBP2, SEC22B, YWHAB, PPIA, MYL12A, HSD17B10, BANF1, CKB, ANXA5, SFXN1, LDHA, RPL30, HNRNPH3, EEF2, ATP1A1, HIST1H2AD, CCT2, EIF4A3, CCT8, RPL26, EEF1G, CDK1, SLC25A5, CHCHD2, RPN2, ATP5H, PPIAL4B, RPL12, LDHAL6A, LDHB, PDIA3, SLC25A3, ARL6IP5, PMVK, HMGB3, RAB10, CKAP4, HSP90B1, MAP4K1, SERPINH1, PSMC2, TMED10, PDIA6, RAB21, EEF1B2, CHCHD3, RUVBL2, TMED9, GANAB, UQCRC1, TMEM109, YWHAQ, YWHAZ, TFAM, YWHAG, SHMT2, PGAM1, YWHAE, PRDX3, MCM3, CCT7, TPI1, PPP2R1A, CANX, EMC2, LMNB2, EIF2S1, APEX1, ELAVL1, LMNA, NDFIP2, ATP6V0D1, DNAJB11, HLA-B, HLA-A, IDH3A, HNRNPA1, JUP, MAT2A, PSMC5, SERBP1, PSMC1, UQCRC2, PRPH, NAMPT, DARS, FARSA, ASNS, LMNB1, RPN1, TKT, SSRP1, DSP, MCM5, HSD17B4, DDX1, PCSK1, CPT1A, DGKG, MCM6, HSPA4, KPNB1, PSMD2, AARS2, TPR, SMC3, COPA, FASN, HDLBP, EPRS, HIST1H2AE, HIST1H2AB, HIST1H2BD, HIST1H2BG, HIST1H2BF, HIST1H2BE, HIST1H2BI, HIST1H2BCPLEKHG4B


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDHA_PLEKHG4B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSDHAP31040DB09270UbidecarenoneSuccinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrialsmall moleculeapproved|investigational|nutraceutical

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RelatedDiseases for SDHA_PLEKHG4B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDHAC0023264Leigh Disease3CTD_human;ORPHANET;UNIPROT
HgeneSDHAC1855008Mitochondrial Complex II Deficiency2CTD_human;ORPHANET;UNIPROT
HgeneSDHAC0029408Degenerative polyarthritis1CTD_human
HgeneSDHAC0036341Schizophrenia1PSYGENET
HgeneSDHAC3279992PARAGANGLIOMAS 51UNIPROT