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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32973

FusionGeneSummary for SDHAP1_CPNE4

check button Fusion gene summary
Fusion gene informationFusion gene name: SDHAP1_CPNE4
Fusion gene ID: 32973
HgeneTgene
Gene symbol

SDHAP1

CPNE4

Gene ID

255812

131034

Gene namesuccinate dehydrogenase complex flavoprotein subunit A pseudogene 1copine 4
SynonymsSDHAL1|SDHALP1COPN4|CPN4
Cytomap

3q29

3q22.1

Type of genepseudoprotein-coding
Descriptionsuccinate dehydrogenase complex, subunit A, flavoprotein pseudogene 1succinate dehydrogenase complex, subunit A, flavoprotein-like 1copine-4copine 8copine IV
Modification date2018051920180523
UniProtAcc

Q96A23

Ensembl transtripts involved in fusion geneENST00000427841, ENST00000512055, 
ENST00000429747, ENST00000512332, 
ENST00000511604, ENST00000502818, 
ENST00000503204, 
Fusion gene scores* DoF score1 X 1 X 1=110 X 7 X 5=350
# samples 110
** MAII scorelog2(1/1*10)=3.32192809488736log2(10/350*10)=-1.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDHAP1 [Title/Abstract] AND CPNE4 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDLGGTCGA-HT-A5RA-01ASDHAP1chr3

195698194

-CPNE4chr3

131404802

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000427841ENST00000512055SDHAP1chr3

195698194

-CPNE4chr3

131404802

-
5UTR-3CDSENST00000427841ENST00000429747SDHAP1chr3

195698194

-CPNE4chr3

131404802

-
5UTR-3CDSENST00000427841ENST00000512332SDHAP1chr3

195698194

-CPNE4chr3

131404802

-
5UTR-3CDSENST00000427841ENST00000511604SDHAP1chr3

195698194

-CPNE4chr3

131404802

-
5UTR-3CDSENST00000427841ENST00000502818SDHAP1chr3

195698194

-CPNE4chr3

131404802

-
5UTR-intronENST00000427841ENST00000503204SDHAP1chr3

195698194

-CPNE4chr3

131404802

-

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FusionProtFeatures for SDHAP1_CPNE4


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDHAP1

CPNE4

Q96A23

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Probable calcium-dependent phospholipid-binding proteinthat may play a role in calcium-mediated intracellular processes.{ECO:0000250|UniProtKB:Q99829}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDHAP1_CPNE4


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDHAP1_CPNE4


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDHAP1TRIM25CPNE4MCM2, HIST1H1A, EBF3, BAHCC1, CPNE6, RABEP2, RPS27A, RPL26L1, RGPD5, GTF3C2, UTRN, ANKRD49, WHSC1, SUPT5H, DHX30, PHOSPHO2, KIAA0020, RSL24D1, STAU1, NOP2, FTSJ3, RPL18A, RPL3


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDHAP1_CPNE4


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDHAP1_CPNE4


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource