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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32962

FusionGeneSummary for SDF4_PPP1R2

check button Fusion gene summary
Fusion gene informationFusion gene name: SDF4_PPP1R2
Fusion gene ID: 32962
HgeneTgene
Gene symbol

SDF4

PPP1R2

Gene ID

51150

5504

Gene namestromal cell derived factor 4protein phosphatase 1 regulatory inhibitor subunit 2
SynonymsCab45|SDF-4IPP-2|IPP2|PPP1R2A
Cytomap

1p36.33

3q29

Type of geneprotein-codingprotein-coding
Description45 kDa calcium-binding proteinprotein phosphatase inhibitor 2phosphoprotein phosphatase
Modification date2018052320180523
UniProtAcc

Q9BRK5

P41236

Ensembl transtripts involved in fusion geneENST00000360001, ENST00000263741, 
ENST00000545427, ENST00000459994, 
ENST00000328432, 
Fusion gene scores* DoF score5 X 5 X 3=751 X 1 X 1=1
# samples 51
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: SDF4 [Title/Abstract] AND PPP1R2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDUCECTCGA-EY-A3QX-01ASDF4chr1

1153838

-PPP1R2chr3

195256702

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000360001ENST00000328432SDF4chr1

1153838

-PPP1R2chr3

195256702

-
Frame-shitENST00000263741ENST00000328432SDF4chr1

1153838

-PPP1R2chr3

195256702

-
intron-3CDSENST00000545427ENST00000328432SDF4chr1

1153838

-PPP1R2chr3

195256702

-
intron-3CDSENST00000459994ENST00000328432SDF4chr1

1153838

-PPP1R2chr3

195256702

-

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FusionProtFeatures for SDF4_PPP1R2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDF4

Q9BRK5

PPP1R2

P41236

Inhibitor of protein-phosphatase 1.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDF4_PPP1R2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDF4_PPP1R2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDF4USP12, MME, RAP1B, SNCA, TK1, CDKN1A, SMN1, RCC1, TTR, ANXA7, CUL3, APP, ZNF512B, RPA2, NR1I2, MOK, HSPA5, ILK, ARAF, ABCE1, IFT122, ACAD11, IQGAP2, MYO9B, GPRIN1, ABCB7, SMC1A, SMC3, RICTOR, GTPBP6, LRFN1, RGPD5, CHSY1, KIAA1671, ARFGEF2, SERAC1, BRCA2, PLD2, ATP2B2, STARD3, KSR1, SIMC1, ARL8B, NCAPD3, NCAPH2, CHST12, GALNT11, NDST2, FOXF2, FOXF1, MTO1, SLC25A16, ZMYM2, FHL2, TTC28, CLU, MADD, SPG7, SLC25A30, SMG8, ERF, NEK4, FAM83H, CHST11, PPOX, KIRREL, MTFR1L, MYC, TUBG1, YWHAZ, PLK4, KIF2C, ITGB3BP, CCDC132, THOC2, ARMC6, POU5F1, PPEF2, PTPN18, ACP5, DUSP21, MAPRE2, PTPN22, PTPRO, TESPPP1R2PPP1CB, PPP1R9B, LMTK2, NEK2, PPP1CA, ELAVL1, TERF2IP, TINF2, PPP1CC, CIAPIN1, GSK3A, GSK3B, GINS4, ISOC1, DCPS, G6PD, MSN, NAE1, NCDN, NSFL1C, PDHA1, PDIA4, PRCP, PROSC, RAP1GDS1, TATDN1, TNFAIP8, TUFM, VCL, YWHAE, ZNF622, TP53BP2, PPP1R3A, PPP1R11, KDM2A, PDIA5, POLR2G, PPP1R7, SFN, SLK, SULT1C3, HIST1H2BG, EWSR1, THOC7, GTF2H5


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDF4_PPP1R2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDF4_PPP1R2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDF4C0036341Schizophrenia1CTD_human