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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32949

FusionGeneSummary for SDCCAG8_CEP170

check button Fusion gene summary
Fusion gene informationFusion gene name: SDCCAG8_CEP170
Fusion gene ID: 32949
HgeneTgene
Gene symbol

SDCCAG8

CEP170

Gene ID

10806

9859

Gene nameserologically defined colon cancer antigen 8centrosomal protein 170
SynonymsBBS16|CCCAP|CCCAP SLSN7|HSPC085|NPHP10|NY-CO-8|SLSN7|hCCCAPFAM68A|KAB|KIAA0470
Cytomap

1q43-q44

1q43

Type of geneprotein-codingprotein-coding
Descriptionserologically defined colon cancer antigen 8Bardet-Biedl syndrome 16antigen NY-CO-8centrosomal colon cancer autoantigen proteinnephrocystin 10centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa
Modification date2018052320180522
UniProtAcc

Q86SQ7

Q5SW79

Ensembl transtripts involved in fusion geneENST00000355875, ENST00000366541, 
ENST00000343783, ENST00000391846, 
ENST00000496361, 		ENST00000366542, 
ENST00000366543, ENST00000366544, 
ENST00000468254, ENST00000481987, 
ENST00000490813, 
Fusion gene scores* DoF score6 X 6 X 5=1801 X 1 X 1=1
# samples 61
** MAII scorelog2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(1/1*10)=3.32192809488736
Context

PubMed: SDCCAG8 [Title/Abstract] AND CEP170 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVHNSCTCGA-BA-4074-01ASDCCAG8chr1

243419542

+CEP170chr1

243336148

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000355875ENST00000366542SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000355875ENST00000366543SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000355875ENST00000366544SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000355875ENST00000468254SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000355875ENST00000481987SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000355875ENST00000490813SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000366541ENST00000366542SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000366541ENST00000366543SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000366541ENST00000366544SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000366541ENST00000468254SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000366541ENST00000481987SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000366541ENST00000490813SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-3CDSENST00000343783ENST00000366542SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-3CDSENST00000343783ENST00000366543SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-3CDSENST00000343783ENST00000366544SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-intronENST00000343783ENST00000468254SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-intronENST00000343783ENST00000481987SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5UTR-intronENST00000343783ENST00000490813SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000391846ENST00000366542SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000391846ENST00000366543SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
Frame-shiftENST00000391846ENST00000366544SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000391846ENST00000468254SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000391846ENST00000481987SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
5CDS-intronENST00000391846ENST00000490813SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-3CDSENST00000496361ENST00000366542SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-3CDSENST00000496361ENST00000366543SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-3CDSENST00000496361ENST00000366544SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-intronENST00000496361ENST00000468254SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-intronENST00000496361ENST00000481987SDCCAG8chr1

243419542

+CEP170chr1

243336148

-
intron-intronENST00000496361ENST00000490813SDCCAG8chr1

243419542

+CEP170chr1

243336148

-

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FusionProtFeatures for SDCCAG8_CEP170


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDCCAG8

Q86SQ7

CEP170

Q5SW79

Plays a role in the establishment of cell polarity andepithelial lumen formation (By similarity). May play a role inciliogenesis. {ECO:0000250|UniProtKB:Q80UF4}. Plays a role in microtubule organization(PubMed:15616186). Required for centriole subdistal appendageassembly (PubMed:28422092). {ECO:0000269|PubMed:15616186,ECO:0000269|PubMed:28422092}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDCCAG8_CEP170


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDCCAG8_CEP170


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SDCCAG8CEP192, SCARA3, KRAS, TENC1, OFD1, IKBKG, CCDC120, LARS, KARS, UBE2NCEP170DISC1, NDEL1, PPP1CA, VAV2, SIRT7, HERC2, NEURL4, YWHAQ, CFTR, PAN2, YWHAB, AGO2, AURKB, CEP57, HAUS2, TUBGCP3, CCDC8, CCAR2, OIP5, PCYT1A, SYNE2, AKAP9, KIFC3, PSPC1, PKD2, ASB7, NIN, RUFY2, CEP170P1, CEP170B, DSTYK, NHSL2, DAPK3, CEP250, SPAG5, PDE4DIP, KNSTRN, STX8, CORO1B, BEGAIN, RFWD3, CCDC6, TNKS, MIS18A, VTI1B, SNAPIN, VAMP8, CCDC68, TEKT2, NTRK1, IFI16, MED4, SRPK2, CEP162, CEP290, RPGRIP1L, LCA5, PCM1, OFD1, AGFG1, ARHGEF2, ASCC3, CEP131, CAMSAP1, CBL, CC2D1A, CCNB1, CKAP2, CRKL, CSNK1A1, DCLK1, DCTN1, FAM83D, HAUS3, HAUS8, HSPA1B, IFT74, KIF2A, KIF2C, KLHL9, NCK1, SHC1, TRIP6, TTK, UNC45A, WDR62, YWHAH, ACTR2, ARRB2, CAMK2D, CCDC138, CCDC77, CSNK2A2, DRG2, GOPC, GPX4, GRB2, GTSE1, HAUS6, HMMR, HS1BP3, LASP1, LIMD1, ERVK3-1, LUZP1, MAP7D1, MAP7D3, MAPRE1, MB21D2, MTAP, MTMR6, MTPN, NARS, NCK2, NEBL, NECAP2, NEDD1, NME7, OCRL, PEA15, PPP1R21, RRM2, SDCBP, SETD7, SKA1, SKA3, SLAIN2, SMAP2, SNX17, SUGT1, TCHP, TMSB10, TXNDC9, UPF1, WRAP73, XIAP, ZC2HC1A, KIAA0753, CEP104, CEP120, CEP128, CEP135, CEP44, CEP89, CNTRL, FBF1, NINL, NPHP1, ODF2, SCLT1, SASS6, CENPJ, C1orf86, XPO1, PRKAR2B, SMC3, FGFR1OP, EGFR, KIF2B, CCDC120, PPP2R3A, C1orf106, EMILIN1, CPN1, VPS53, CCDC151, CBY1, CSNK2A1, CSNK2B, YWHAE, KIFAP3, DCAF7, INPP5E, RAB3IP, KIF3A, NCL


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDCCAG8_CEP170


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDCCAG8_CEP170


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDCCAG8C0035309Retinal Diseases1CTD_human
HgeneSDCCAG8C0036341Schizophrenia1PSYGENET
HgeneSDCCAG8C1691228Cystic Kidney Diseases1CTD_human