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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32946

FusionGeneSummary for SDCBP_SDCBP

check button Fusion gene summary
Fusion gene informationFusion gene name: SDCBP_SDCBP
Fusion gene ID: 32946
HgeneTgene
Gene symbol

SDCBP

SDCBP

Gene ID

6386

6386

Gene namesyndecan binding proteinsyndecan binding protein
SynonymsMDA-9|MDA9|ST1|SYCL|TACIP18MDA-9|MDA9|ST1|SYCL|TACIP18
Cytomap

8q12.1

8q12.1

Type of geneprotein-codingprotein-coding
Descriptionsyntenin-1melanoma differentiation associated protein-9pro-TGF-alpha cytoplasmic domain-interacting protein 18scaffold protein Pbp1syndecan binding protein (syntenin)syndecan-binding protein 1syntenin-1melanoma differentiation associated protein-9pro-TGF-alpha cytoplasmic domain-interacting protein 18scaffold protein Pbp1syndecan binding protein (syntenin)syndecan-binding protein 1
Modification date2018052320180523
UniProtAcc

O00560

O00560

Ensembl transtripts involved in fusion geneENST00000522243, ENST00000422546, 
ENST00000260130, ENST00000447182, 
ENST00000413219, ENST00000424270, 
ENST00000523483, ENST00000520168, 
ENST00000447267, 		ENST00000522243, 
ENST00000422546, ENST00000260130, 
ENST00000447182, ENST00000413219, 
ENST00000424270, ENST00000523483, 
ENST00000520168, ENST00000447267, 
Fusion gene scores* DoF score4 X 3 X 2=243 X 3 X 2=18
# samples 43
** MAII scorelog2(4/24*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SDCBP [Title/Abstract] AND SDCBP [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSDCBP

GO:0042327

positive regulation of phosphorylation

18256285

TgeneSDCBP

GO:0042327

positive regulation of phosphorylation

18256285


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CN277922SDCBPchr8

59495283

-SDCBPchr8

59495338

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000522243ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000522243ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000522243ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000522243ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000522243ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000522243ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000522243ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000522243ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000522243ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000422546ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000422546ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000422546ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000422546ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000422546ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000422546ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000422546ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000422546ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000422546ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000260130ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000260130ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000260130ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000260130ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000260130ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000260130ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000260130ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000260130ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000260130ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000447182ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000447182ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000447182ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000447182ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000447182ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000447182ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000447182ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000447182ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000447182ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000413219ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000413219ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000413219ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000413219ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000413219ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000413219ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000413219ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000413219ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000413219ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000424270ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000424270ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000424270ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000424270ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000424270ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000424270ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000424270ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000424270ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000424270ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000523483ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000523483ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000523483ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000523483ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000523483ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000523483ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-3UTRENST00000523483ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000523483ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
3UTR-intronENST00000523483ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000520168ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000520168ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000520168ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000520168ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000520168ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000520168ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000520168ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000520168ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000520168ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000447267ENST00000522243SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000447267ENST00000422546SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000447267ENST00000260130SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000447267ENST00000447182SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000447267ENST00000413219SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000447267ENST00000424270SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-3UTRENST00000447267ENST00000523483SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000447267ENST00000520168SDCBPchr8

59495283

-SDCBPchr8

59495338

+
intron-intronENST00000447267ENST00000447267SDCBPchr8

59495283

-SDCBPchr8

59495338

+

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FusionProtFeatures for SDCBP_SDCBP


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDCBP

O00560

SDCBP

O00560

Multifunctional adapter protein involved in diversearray of functions including trafficking of transmembraneproteins, neuro and immunomodulation, exosome biogenesis, andtumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various celltypes. May increase TGFB1 signaling by enhancing cell-surfaceexpression of TGFR1 by preventing the interaction between TGFR1and CAV1 and subsequent CAV1-dependent internalization anddegradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 andPDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulatesmigration, growth, proliferation, and cell cycle progression in avariety of cancer types (PubMed:26539120). In adherens junctionsmay function to couple syndecans to cytoskeletal proteins orsignaling components. Seems to couple transcription factor SOX4 tothe IL-5 receptor (IL5RA) (PubMed:11498591). May also play a rolein vesicular trafficking (PubMed:11179419). Seems to be requiredfor the targeting of TGFA to the cell surface in the earlysecretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395,ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591,ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292,ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}. Multifunctional adapter protein involved in diversearray of functions including trafficking of transmembraneproteins, neuro and immunomodulation, exosome biogenesis, andtumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various celltypes. May increase TGFB1 signaling by enhancing cell-surfaceexpression of TGFR1 by preventing the interaction between TGFR1and CAV1 and subsequent CAV1-dependent internalization anddegradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 andPDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulatesmigration, growth, proliferation, and cell cycle progression in avariety of cancer types (PubMed:26539120). In adherens junctionsmay function to couple syndecans to cytoskeletal proteins orsignaling components. Seems to couple transcription factor SOX4 tothe IL-5 receptor (IL5RA) (PubMed:11498591). May also play a rolein vesicular trafficking (PubMed:11179419). Seems to be requiredfor the targeting of TGFA to the cell surface in the earlysecretory pathway (PubMed:10230395). {ECO:0000269|PubMed:10230395,ECO:0000269|PubMed:11179419, ECO:0000269|PubMed:11498591,ECO:0000269|PubMed:22660413, ECO:0000269|PubMed:25893292,ECO:0000269|PubMed:26539120, ECO:0000303|PubMed:26291527}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDCBP_SDCBP


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDCBP_SDCBP


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDCBP_SDCBP


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDCBP_SDCBP


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDCBPC0029408Degenerative polyarthritis1CTD_human
TgeneSDCBPC0029408Degenerative polyarthritis1CTD_human