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Fusion gene ID: 32940 |
FusionGeneSummary for SDC4_YWHAB |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: SDC4_YWHAB | Fusion gene ID: 32940 | Hgene | Tgene | Gene symbol | SDC4 | YWHAB | Gene ID | 6385 | 7529 |
| Gene name | syndecan 4 | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta | |
| Synonyms | SYND4 | GW128|HEL-S-1|HS1|KCIP-1|YWHAA | |
| Cytomap | 20q13.12 | 20q13.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | syndecan-4amphiglycanryudocan amphiglycanryudocan core proteinsyndecan 4 (amphiglycan, ryudocan)syndecan proteoglycan 4 | 14-3-3 protein beta/alpha14-3-3 alphabrain protein 14-3-3, beta isoformepididymis secretory protein Li 1protein 1054protein kinase C inhibitor protein-1tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptidetyrosin | |
| Modification date | 20180523 | 20180522 | |
| UniProtAcc | P31431 | P31946 | |
| Ensembl transtripts involved in fusion gene | ENST00000372733, ENST00000537976, | ENST00000353703, ENST00000479421, ENST00000372839, | |
| Fusion gene scores | * DoF score | 9 X 7 X 8=504 | 4 X 7 X 2=56 |
| # samples | 13 | 9 | |
| ** MAII score | log2(13/504*10)=-1.95491211047146 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(9/56*10)=0.684498174272071 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
| Context | PubMed: SDC4 [Title/Abstract] AND YWHAB [Title/Abstract] AND fusion [Title/Abstract] | ||
| Functional or gene categories assigned by FusionGDB annotation | |||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | YWHAB | GO:0035308 | negative regulation of protein dephosphorylation | 17255105 |
| Tgene | YWHAB | GO:0043085 | positive regulation of catalytic activity | 17255105 |
| Tgene | YWHAB | GO:0051220 | cytoplasmic sequestering of protein | 10869435 |
| Fusion gene information from three resources (ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018)) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Data type | Source | Cancer type | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| TCGA | RV | LUAD | TCGA-97-8177-01A | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| * LD: Li Ding group's fusion gene list RV: Roel Verhaak group's fusion gene list ChiTaRs fusion database |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| In-frame | ENST00000372733 | ENST00000353703 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| 5CDS-3UTR | ENST00000372733 | ENST00000479421 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| 5CDS-3UTR | ENST00000372733 | ENST00000372839 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| 5UTR-3CDS | ENST00000537976 | ENST00000353703 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| 5UTR-3UTR | ENST00000537976 | ENST00000479421 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
| 5UTR-3UTR | ENST00000537976 | ENST00000372839 | SDC4 | chr20 | 43976965 | - | YWHAB | chr20 | 43532634 | + |
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FusionProtFeatures for SDC4_YWHAB |
| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| SDC4 | YWHAB |
| Cell surface proteoglycan that bears heparan sulfate.Regulates exosome biogenesis in concert with SDCBP and PDCD6IP(PubMed:22660413). {ECO:0000269|PubMed:22660413}. | Adapter protein implicated in the regulation of a largespectrum of both general and specialized signaling pathways. Bindsto a large number of partners, usually by recognition of aphosphoserine or phosphothreonine motif. Binding generally resultsin the modulation of the activity of the binding partner. Negativeregulator of osteogenesis. Blocks the nuclear translocation of thephosphorylated form (by AKT1) of SRPK2 and antagonizes itsstimulatory effect on cyclin D1 expression resulting in blockageof neuronal apoptosis elicited by SRPK2. Negative regulator ofsignaling cascades that mediate activation of MAP kinases viaAKAP13. {ECO:0000269|PubMed:17717073, ECO:0000269|PubMed:19592491,ECO:0000269|PubMed:21224381}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at . * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | >SDC4 | chr20:43976965 | chr20:43532634 | ENST00000372733 | - | 1 | 5 | 171_198 | 20 | 199 | Topological domain | Cytoplasmic |
| Hgene | >SDC4 | chr20:43976965 | chr20:43532634 | ENST00000372733 | - | 1 | 5 | 19_145 | 20 | 199 | Topological domain | Extracellular |
| Hgene | >SDC4 | chr20:43976965 | chr20:43532634 | ENST00000372733 | - | 1 | 5 | 146_170 | 20 | 199 | Transmembrane | Helical |
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FusionGeneSequence for SDC4_YWHAB |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. (nt: nucleotides, aa: amino acids) |
| * Fusion amino acid sequences. |
| >In-frame_SDC4_ENST00000372733_chr20_43976965_-_YWHAB_ENST00000353703_chr20_43532634_+_167aa MAPARLFALLLFFVGGVAESELLDKYLIPNATQPESKVFYLKMKGDYFRYLSEVASGDNKQTTVSNSQQAYQEAFEISKKEMQPTHPIRL |
| * Fusion transcript sequences (only coding sequence (CDS) region). |
| >In-frame_SDC4_ENST00000372733_chr20_43976965_-_YWHAB_ENST00000353703_chr20_43532634_+_501nt ATGGCCCCCGCCCGTCTGTTCGCGCTGCTGCTGTTCTTCGTAGGCGGAGTCGCCGAGTCGGAGCTGTTGGACAAATATCTTATTCCCAAT GCTACACAACCAGAAAGTAAGGTGTTCTACTTGAAAATGAAAGGAGATTATTTTAGGTATCTTTCTGAAGTGGCATCTGGAGACAACAAA CAAACCACTGTGTCGAACTCCCAGCAGGCTTACCAGGAAGCATTTGAAATTAGTAAGAAAGAAATGCAGCCTACACACCCAATTCGTCTT GGTCTGGCACTAAATTTCTCAGTCTTTTACTATGAGATTCTAAACTCTCCTGAAAAGGCCTGTAGCCTGGCAAAAACGGCATTTGATGAA GCAATTGCTGAATTGGATACGCTGAATGAAGAGTCTTATAAAGACAGCACTCTGATCATGCAGTTACTTAGGGACAATCTCACTCTGTGG |
| * Fusion transcript sequences (Full-length transcript). |
| >In-frame_SDC4_ENST00000372733_chr20_43976965_-_YWHAB_ENST00000353703_chr20_43532634_+_2635nt ACTCGCCGCAGCCTGCGCGCCTTCTCCAGTCCGCGGTGCCATGGCCCCCGCCCGTCTGTTCGCGCTGCTGCTGTTCTTCGTAGGCGGAGT CGCCGAGTCGGAGCTGTTGGACAAATATCTTATTCCCAATGCTACACAACCAGAAAGTAAGGTGTTCTACTTGAAAATGAAAGGAGATTA TTTTAGGTATCTTTCTGAAGTGGCATCTGGAGACAACAAACAAACCACTGTGTCGAACTCCCAGCAGGCTTACCAGGAAGCATTTGAAAT TAGTAAGAAAGAAATGCAGCCTACACACCCAATTCGTCTTGGTCTGGCACTAAATTTCTCAGTCTTTTACTATGAGATTCTAAACTCTCC TGAAAAGGCCTGTAGCCTGGCAAAAACGGCATTTGATGAAGCAATTGCTGAATTGGATACGCTGAATGAAGAGTCTTATAAAGACAGCAC TCTGATCATGCAGTTACTTAGGGACAATCTCACTCTGTGGACATCGGAAAACCAGGGAGACGAAGGAGACGCTGGGGAGGGAGAGAACTA ATGTTTCTCGTGCTTTGTGATCTGTTCAGTGTCACTCTGTACCCTCAACATATATCCCTTGTGCGATAAAAAAAAAAAAAAAAAAAAAAA GAGAATCGTACGTCGACTTTCGATTTTTCACAGCCTCAGCCTAGGAAAAATGGTTCATGGGATAAACAGCTGGTATTTGTATCTAAAACT CAGATTGGTCACATAAATGCCACGGCATTCCGAAGTTTTGATTTTGATTAACATTGACAGGATTACTGTGTGTTTAATTTTTTAAAAACT GAACACTGTGATTATGGGGTTTTGTAATTTAGCAGAACTCTTACTGGTAGAAAAAATAGACCTGAATTATGTGTAACTTTTTGGAAGGTT TAATCTGATATCAAAATAATCATTGAAATACAATTCCATTGTAAAGTTGTACAGAAAGTTATAGAGATTATATTGTGATGCTGGAACTTG GAGTGAGACACACATCATTTGGCATTTGAGTTGAATGGTAATTCACAGTAATGCTGCCGTTGTTCGGGACTTAAAGACACTTGACCTGTT TGGGCTGTTGCCACTTAAAAGTTCATGACCACAAATGTCCACAGTGTCTTCCTCTGAGGAAACTCGAATCCTGAAATGGAAATTCTTTGT GGCAGATAACTGGCTTATGACACCTTGAAAAGTTCAAGTGCTCATATAACACACCACACTGAACCCCCTTTCCTACAGCAATATGTTCAC TATGTTACCAATTTGCAACTTGTGCTTCAATAGTGGAATCTACTTTCATTGTTAACACTGAGCTAAAGAAAAAAAGCCGTGTGTTTTATG AATGACCTTATCTGTTTCCTGGATAATACCTTTAAGAATAATGTCCTGAGTCAGGCGTGGTGGTGCGTGCATCTAGTCCCAACTATTTGG GAGGCTGAGGCAGGAGGATCGCTTGAGCCCAGGAGTTTAAAGCTGCAGTGCCCTGTGGTTGCACCTGTGAATAACTGCACTCCAGCCTGG GCAACATAGCGAGACCTCATCTCCAAAAAAGAAAACAAAAAACAAAAAAAGGAATGATGTTCTGTAGAGATGGCCTTTCACTTGAGGAGT ACTCAGTTTTCAGGTTCTTCCTAGCTCGGGGCTTTTAAATTTTGAAATCTAAACATTCTTTCCCACCATCCTTTTTGACTGTTGACCTTG GTTTTCTCTTCTAAGTTTCTGTCCCTCTGCTTCCTTACTTTTTTTCCTTTTTGAATTCTATCTTTATCTGTCTTTTGTTCACTTTTTAAT GCTATATATGGGCAGGGGTGAGAGACATTACTGAGCACCTTGGTGAGCAAGCCTGGCTTTAAAGATTGGAGAAGAGCTTCTGGCACCAGA ACCCTGTCTTCCTCCAGTTCTCAACACGGTGTTGCTCTTCAGTCATACCGGAATCTGAATCAAAAAAGTATTTTTAAATATCCATGATTT CTCCCTGTATTGAGGCTAGCCCTGATCATGCTTTTTGTGCCTGTCACCAGGTCTCCCAAGTGCACTCATCCAGGTCAGTGCTCAGATGTG TTTAAGGAGACCCTATATTCAGGGAAGTTGCGTGAACACTGCAGTGGGGAGAATTGAGAATAGTCAGGCCTATCAGTCTCACAGAATCAC CCCTCTACCTTTGATATTCCACTTAGCTGTAGAGTCCATCTGTTTGTCCATCTGCTGAAATGAGAAAAGAAAAATTTATGCACTGATTTA AAACAAACCAAAAAAAAAGAAAAAAACAAAAAAAAAAATCCCTCCTTTCTAGCTGAACAAAAATGTGCAGTTAATACTTGGCGCTTGAAA ATGCAGTAGTGAATGTGGAACCAAGCCTGTCTGTATATCTGGTAGCTCTTTTCTTGCTTTGTTTTTTCTTACCAGTATTCTGCCTAACGT TTGCTTCTGTGATGGTTATATTGCCTAGCAAGCACACCCGTGGTTGTGAAAATAGTATAGCAAAAAAGAAAAATCCCCGGTTATTGATGT ACTAGATTTGTGTATGTCTTTTAAACAGTTCTAGTTTCACCTTACACAGAATAATCAGGAAAAGTGTAAAAATTCAAAAGTGAAATAAAA |
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FusionGenePPI for SDC4_YWHAB |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in . |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| SDC4 | FGF2, CCL5, GIPC1, DVL1, ELAVL1, MYC, TGFB3, TANK, SGTA, FGF1, PTEN, DBN1, RARRES3, CYLD, GPR183, UBC | YWHAB | KIF5B, MPRIP, SRRM2, IRS2, RAI14, SAMD4B, BRAF, PI4KB, USP8, EPB41L3, PARD3, KLC1, MLLT4, RACGAP1, KIF23, EDC3, TJP2, FOXK1, DENND4A, FRYL, SLC4A7, MARK3, NCKAP1, AKAP13, OSBPL3, CGN, RMDN3, RABGEF1, LARP1, CSNK2A1, RASGRF1, MAPK7, RAF1, RPS6KA1, HDAC4, HDAC5, WEE1, BAD, PTPN3, ZFP36, IGF1R, RGS3, CBL, KCNK3, TESK1, TESK2, IRS1, PRKCZ, PRPF6, MLXIP, TNFAIP3, CDC25B, LYST, ITGB1, MAPT, CDC25A, UCP2, UCP3, USP43, USP32, WDR20, MDM4, FOXO3, CDC25C, TSC2, TSC1, YWHAE, ING1, CAMK2A, CAMK2B, EMD, SAMSN1, HDAC7, EXO1, CHAF1A, H2AFX, MYC, NEDD4L, YWHAQ, SKP2, ATP5A1, C1QBP, DHX15, HSPA1B, HSPA5, HSP90AB1, SRSF3, SON, UBC, DOCK4, PIK3R2, MAP3K2, SRSF10, RNPS1, STK38, TUBA3C, STK38L, MYCBP2, KIAA0930, GAPVD1, PIK3R4, LSR, RALGPS2, ALS2, WDR77, RIOK1, MICALL1, FRMD6, CRTC2, TUBB, MAP2K1, MAP2K2, RFWD2, OPTN, HES1, CDKN1B, HIST1H3A, ELAVL1, ARRB1, ARRB2, CUL3, DCUN1D1, ITGB2, PTPN14, MEX3B, MARK2, LRRK2, KIF13B, GRK5, APP, ACTA2, ATG4B, ECT2, HNF1A, VCP, FN1, VCAM1, ZFP36L1, ATF2, IQCB1, GRB2, TRIM32, ITGA4, CBX4, ABL1, PHB, BAX, MST1R, KCNK9, KCNJ11, GPR15, BAG3, BCL2L11, CDK11B, SRPK2, KLC2, RASSF2, YAP1, ABLIM1, AGAP3, AKT1S1, AMPD2, ANKS1A, ARAF, ARHGEF2, CEP131, BAIAP2, VIPAS39, CAMKK1, CCDC6, CDC42EP1, CDK16, CDK17, CDK18, CEP170, CLASP1, CLASP2, NELFB, CRTC3, CYFIP2, CYLD, DCAF7, DDX6, DENND1A, DENND4C, DOCK11, EIF4E2, DMTN, FAM83B, GBF1, GIGYF1, GIGYF2, GRIP1, HGS, INPP5F, IRS4, CEP170B, KIAA0355, KIAA1671, KIAA1804, KIF1B, KIF1C, KLC4, KSR1, LIMA1, LMO7, LUZP1, MARK1, MAST2, MTMR12, NADK, NAV1, NCKIPSD, NF1, PAK4, PARP8, PFKFB2, PHLDB2, PIK3C2A, PKP2, PLEKHA5, PLEKHA7, PPFIA1, PPFIBP1, PPM1H, PPP2R5D, PTPN13, PUM1, R3HDM1, R3HDM2, RAB11FIP1, RAB11FIP2, RAPGEF6, RASAL2, REEP4, RICTOR, RTKN, SAMD4A, SH3PXD2A, SH3RF1, SH3RF3, SHKBP1, SHROOM3, SIPA1L2, SIPA1L3, SKIV2L2, SORBS1, SORBS2, SRGAP2, STAM, STK3, TANC2, TBC1D1, TBC1D22A, TBC1D22B, TBC1D4, TBC1D5, TP53BP2, TPD52L1, TTC28, UHRF1BP1L, USP54, VPS33B, WDR62, NELFA, WNK1, YWHAG, YWHAH, YWHAZ, ZAK, ZCCHC8, ZFP36L2, CAPZA1, PAFAH1B2, PAK2, PGD, SLC9A3R1, SMS, BCCIP, DAK, G6PD, GSS, LDHB, RRAGB, SGTA, TUBB4B, SIK3, DDIT4, DTL, CUL7, RNF115, EGFR, MAST1, TNK1, BTRC, FBXW11, FRMD5, WWC1, HSPB1, UNK, NCAPD3, PITHD1, SLK, NTRK1, HIST1H2BG, LCA5, CHORDC1, CENPJ, PPARG, CRY1, MCM2, DACT1, NFATC2, ERRFI1, CDC73, CDH1, DUSP16, MTMR4, SMTNL2, SPATA13, PRICKLE3, TESPA1, SFN, FAM189A2, NKD2, STAC, TFEB, FAM163A, PTPDC1, PTPN4, SSH1, MTNR1A, MTNR1B, DLD, DNM1L, PARK7, SDHA, SOAT1, SOD1, FOXA1, TRIM25, G3BP1, URI1, BRD1, TP53 |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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RelatedDrugs for SDC4_YWHAB |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.0 2018-04-02) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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RelatedDiseases for SDC4_YWHAB |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Hgene | SDC4 | C0007131 | Non-Small Cell Lung Carcinoma | 1 | CTD_human |
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