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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32933

FusionGeneSummary for SDC4_BIN1

check button Fusion gene summary
Fusion gene informationFusion gene name: SDC4_BIN1
Fusion gene ID: 32933
HgeneTgene
Gene symbol

SDC4

BIN1

Gene ID

6385

274

Gene namesyndecan 4bridging integrator 1
SynonymsSYND4AMPH2|AMPHL|CNM2|SH3P9
Cytomap

20q13.12

2q14.3

Type of geneprotein-codingprotein-coding
Descriptionsyndecan-4amphiglycanryudocan amphiglycanryudocan core proteinsyndecan 4 (amphiglycan, ryudocan)syndecan proteoglycan 4myc box-dependent-interacting protein 1amphiphysin IIamphiphysin-like proteinbox dependant MYC interacting protein 1box-dependent myc-interacting protein 1
Modification date2018052320180522
UniProtAcc

P31431

O00499

Ensembl transtripts involved in fusion geneENST00000372733, ENST00000537976, 
ENST00000376113, ENST00000346226, 
ENST00000352848, ENST00000393041, 
ENST00000348750, ENST00000357970, 
ENST00000259238, ENST00000393040, 
ENST00000351659, ENST00000316724, 
ENST00000409400, ENST00000466111, 
Fusion gene scores* DoF score9 X 7 X 8=5045 X 5 X 3=75
# samples 136
** MAII scorelog2(13/504*10)=-1.95491211047146
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/75*10)=-0.321928094887362
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SDC4 [Title/Abstract] AND BIN1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBIN1

GO:0043065

positive regulation of apoptotic process

16530520

TgeneBIN1

GO:0071156

regulation of cell cycle arrest

10412034


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1CB136042SDC4chr20

43954796

-BIN1chr2

127805682

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000372733ENST00000376113SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000346226SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000352848SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000393041SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000348750SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000357970SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000259238SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000393040SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000351659SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000316724SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000372733ENST00000409400SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-intronENST00000372733ENST00000466111SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000376113SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000346226SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000352848SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000393041SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000348750SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000357970SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000259238SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000393040SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000351659SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000316724SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-3UTRENST00000537976ENST00000409400SDC4chr20

43954796

-BIN1chr2

127805682

-
intron-intronENST00000537976ENST00000466111SDC4chr20

43954796

-BIN1chr2

127805682

-

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FusionProtFeatures for SDC4_BIN1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SDC4

P31431

BIN1

O00499

Cell surface proteoglycan that bears heparan sulfate.Regulates exosome biogenesis in concert with SDCBP and PDCD6IP(PubMed:22660413). {ECO:0000269|PubMed:22660413}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SDC4_BIN1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SDC4_BIN1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SDC4_BIN1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SDC4_BIN1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSDC4C0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneBIN1C0002395Alzheimer's Disease1CTD_human
TgeneBIN1C0410204Myopathy, Centronuclear, Autosomal Recessive1CTD_human;ORPHANET;UNIPROT
TgeneBIN1C0752282Congenital Structural Myopathy1CTD_human