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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32912

FusionGeneSummary for SCYL2_PTPRG

check button Fusion gene summary
Fusion gene informationFusion gene name: SCYL2_PTPRG
Fusion gene ID: 32912
HgeneTgene
Gene symbol

SCYL2

PTPRG

Gene ID

55681

5793

Gene nameSCY1 like pseudokinase 2protein tyrosine phosphatase, receptor type G
SynonymsCVAK104HPTPG|PTPG|R-PTP-GAMMA|RPTPG
Cytomap

12q23.1

3p14.2

Type of geneprotein-codingprotein-coding
DescriptionSCY1-like protein 2SCY1-like 2SCY1-like, kinase-like 2coated vesicle-associated kinase of 104 kDareceptor-type tyrosine-protein phosphatase gammaH_RG317H01.1protein tyrosine phosphatase gammaprotein tyrosine phosphatase, receptor type, gamma polypeptidereceptor type protein tyrosine phosphatase gammareceptor tyrosine phosphatase gammareceptor-t
Modification date2018051920180527
UniProtAcc

Q6P3W7

P23470

Ensembl transtripts involved in fusion geneENST00000550067, ENST00000360820, 
ENST00000295874, ENST00000474889, 
ENST00000495879, 
Fusion gene scores* DoF score6 X 6 X 6=2168 X 6 X 5=240
# samples 68
** MAII scorelog2(6/216*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(8/240*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCYL2 [Title/Abstract] AND PTPRG [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCYL2

GO:0002092

positive regulation of receptor internalization

19643732

HgeneSCYL2

GO:0008333

endosome to lysosome transport

19643732

HgeneSCYL2

GO:0090090

negative regulation of canonical Wnt signaling pathway

19643732

HgeneSCYL2

GO:2000286

receptor internalization involved in canonical Wnt signaling pathway

19643732

HgeneSCYL2

GO:2000370

positive regulation of clathrin-dependent endocytosis

19643732


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1AK027551SCYL2chr12

100733190

+PTPRGchr3

61728149

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-intronENST00000550067ENST00000295874SCYL2chr12

100733190

+PTPRGchr3

61728149

-
intron-intronENST00000550067ENST00000474889SCYL2chr12

100733190

+PTPRGchr3

61728149

-
intron-intronENST00000550067ENST00000495879SCYL2chr12

100733190

+PTPRGchr3

61728149

-
3UTR-intronENST00000360820ENST00000295874SCYL2chr12

100733190

+PTPRGchr3

61728149

-
3UTR-intronENST00000360820ENST00000474889SCYL2chr12

100733190

+PTPRGchr3

61728149

-
3UTR-intronENST00000360820ENST00000495879SCYL2chr12

100733190

+PTPRGchr3

61728149

-

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FusionProtFeatures for SCYL2_PTPRG


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCYL2

Q6P3W7

PTPRG

P23470

Component of AP2-containing clathrin coated structuresat the plasma membrane or of endocytic coated vesicles. Accordingto PubMed:15809293, probable serine/threonine-protein kinase thatphosphorylates, in vitro, the beta2-subunit of the plasma membraneadapter complex AP2 and other proteins in presence of poly-L-lysine. According to PubMed:16914521, has no detectable kinaseactivity in vitro. May regulate clathrin-dependent traffickingbetween the TGN and/or the endosomal system.{ECO:0000269|PubMed:15809293, ECO:0000269|PubMed:16914521}. Possesses tyrosine phosphatase activity.{ECO:0000269|PubMed:19167335}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCYL2_PTPRG


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCYL2_PTPRG


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCYL2_PTPRG


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCYL2_PTPRG


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePTPRGC0038356Stomach Neoplasms1CTD_human