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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3290

FusionGeneSummary for ATP13A4_NAALADL2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP13A4_NAALADL2
Fusion gene ID: 3290
HgeneTgene
Gene symbol

ATP13A4

NAALADL2

Gene ID

84239

254827

Gene nameATPase 13A4N-acetylated alpha-linked acidic dipeptidase like 2
Synonyms--
Cytomap

3q29

3q26.31

Type of geneprotein-codingprotein-coding
Descriptionprobable cation-transporting ATPase 13A4ATPase type 13A4P5-ATPasecation-transporting P5-ATPaseinactive N-acetylated-alpha-linked acidic dipeptidase-like protein 2N-acetylated alpha-linked acidic dipeptidase 2NAALADase L2glutamate carboxypeptidase II-type non-peptidase homologue
Modification date2018052320180519
UniProtAcc

Q4VNC1

Q58DX5

Ensembl transtripts involved in fusion geneENST00000392443, ENST00000342695, 
ENST00000295548, ENST00000400270, 
ENST00000482964, 
ENST00000454872, 
ENST00000473253, 
Fusion gene scores* DoF score1 X 1 X 1=115 X 8 X 7=840
# samples 115
** MAII scorelog2(1/1*10)=3.32192809488736log2(15/840*10)=-2.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ATP13A4 [Title/Abstract] AND NAALADL2 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-60-2711-01AATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000392443ENST00000454872ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
5CDS-3UTRENST00000392443ENST00000473253ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
Frame-shitENST00000342695ENST00000454872ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
5CDS-3UTRENST00000342695ENST00000473253ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
Frame-shitENST00000295548ENST00000454872ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
5CDS-3UTRENST00000295548ENST00000473253ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
intron-3CDSENST00000400270ENST00000454872ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
intron-3UTRENST00000400270ENST00000473253ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
intron-3CDSENST00000482964ENST00000454872ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+
intron-3UTRENST00000482964ENST00000473253ATP13A4chr3

193272529

-NAALADL2chr3

174814580

+

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FusionProtFeatures for ATP13A4_NAALADL2


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP13A4

Q4VNC1

NAALADL2

Q58DX5

May be catalytically inactive.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP13A4_NAALADL2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP13A4_NAALADL2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP13A4NAALADL2CUL3, APP, GPR25, GRM2, SLC30A3, ITM2B, LAPTM4B, SCAP, KLC2, NAALAD2, KCTD17, IGSF3, ERBB2, KCNJ8, CELSR2, SCARB2, HLA-DRB1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP13A4_NAALADL2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP13A4_NAALADL2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource