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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32893

FusionGeneSummary for SCRN1_WDR53

check button Fusion gene summary
Fusion gene informationFusion gene name: SCRN1_WDR53
Fusion gene ID: 32893
HgeneTgene
Gene symbol

SCRN1

WDR53

Gene ID

9805

348793

Gene namesecernin 1WD repeat domain 53
SynonymsSES1-
Cytomap

7p14.3

3q29

Type of geneprotein-codingprotein-coding
Descriptionsecernin-1WD repeat-containing protein 53WD domain, G-beta repeat-containing protein
Modification date2018052320180519
UniProtAcc

Q12765

Q7Z5U6

Ensembl transtripts involved in fusion geneENST00000242059, ENST00000426154, 
ENST00000425819, ENST00000434476, 
ENST00000494620, ENST00000409570, 
ENST00000409497, ENST00000416113, 
ENST00000332629, ENST00000429115, 
ENST00000433160, 
Fusion gene scores* DoF score2 X 1 X 1=23 X 1 X 2=6
# samples 23
** MAII scorelog2(2/2*10)=3.32192809488736log2(3/6*10)=2.32192809488736
Context

PubMed: SCRN1 [Title/Abstract] AND WDR53 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVLUSCTCGA-66-2769-01ASCRN1chr7

30029258

-WDR53chr3

196281678

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000242059ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000242059ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000242059ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-3CDSENST00000426154ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000426154ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000426154ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-3CDSENST00000425819ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000425819ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000425819ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-3CDSENST00000434476ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000434476ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000434476ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-3CDSENST00000494620ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000494620ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000494620ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-3CDSENST00000409570ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000409570ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
5UTR-5UTRENST00000409570ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-3CDSENST00000409497ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000409497ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000409497ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-3CDSENST00000416113ENST00000332629SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000416113ENST00000429115SCRN1chr7

30029258

-WDR53chr3

196281678

-
intron-5UTRENST00000416113ENST00000433160SCRN1chr7

30029258

-WDR53chr3

196281678

-

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FusionProtFeatures for SCRN1_WDR53


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCRN1

Q12765

WDR53

Q7Z5U6

Regulates exocytosis in mast cells. Increases both theextent of secretion and the sensitivity of mast cells tostimulation with calcium (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCRN1_WDR53


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCRN1_WDR53


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCRN1HGS, NAGK, GDI1, GNAI2, HMGB3, C11orf58, GORASP1, TAB2, TAB1, CD3EAP, MAP3K7, CCDC85C, DENND4A, CTU1, POPDC3, CCDC121, VAPA, FGBWDR53WDR5, BBS1, RSAD1, EEF1A2, NACAD, BLVRA, MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCRN1_WDR53


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCRN1_WDR53


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSCRN1C0029408Degenerative polyarthritis1CTD_human
HgeneSCRN1C0038356Stomach Neoplasms1CTD_human