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Fusion gene ID: 32884

FusionGeneSummary for SCP2_NCAM1

Fusion gene summary

Fusion gene information	Fusion gene name: SCP2_NCAM1
	Fusion gene ID: 32884
		Hgene	Tgene
	Gene symbol	SCP2	NCAM1
	Gene ID	10388	4684
	Gene name	synaptonemal complex protein 2	neural cell adhesion molecule 1
	Synonyms	SCP-2\|SCP2	CD56\|MSK39\|NCAM
	Cytomap	20q13.33	11q23.2
	Type of gene	protein-coding	protein-coding
	Description	synaptonemal complex protein 2synaptonemal complex lateral element protein	neural cell adhesion molecule 1antigen recognized by monoclonal antibody 5.1H11neural cell adhesion molecule, NCAM
	Modification date	20180519	20180523
	UniProtAcc	P22307	P13591
	Ensembl transtripts involved in fusion gene	ENST00000371514, ENST00000528311, ENST00000371509, ENST00000407246, ENST00000371513, ENST00000473584, ENST00000430330, ENST00000408941, ENST00000435345, ENST00000488965,	ENST00000533760, ENST00000397957, ENST00000316851, ENST00000401611,
Fusion gene scores	* DoF score	6 X 5 X 4=120	8 X 9 X 4=288
	# samples	6	10
	** MAII score	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context	PubMed: SCP2 [Title/Abstract] AND NCAM1 [Title/Abstract] AND fusion [Title/Abstract]
Functional or gene categories assigned by FusionGDB annotation

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Data type	Source	Cancer type	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
TCGA	RV	PRAD	TCGA-V1-A9ZG-01A	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
TCGA	LD	PRAD	TCGA-V1-A9ZG-01A	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+

* LD: Li Ding group's fusion gene list
RV: Roel Verhaak group's fusion gene list
ChiTaRs fusion database

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
Frame-shift	ENST00000371514	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371514	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371514	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371514	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3CDS	ENST00000528311	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3UTR	ENST00000528311	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-3UTR	ENST00000528311	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5UTR-intron	ENST00000528311	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371509	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371509	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371509	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371509	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000407246	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000407246	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000407246	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000407246	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371513	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371513	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-3UTR	ENST00000371513	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
5CDS-intron	ENST00000371513	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000473584	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000473584	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000473584	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000473584	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000430330	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000430330	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000430330	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000430330	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000408941	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000408941	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000408941	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000408941	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000435345	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000435345	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000435345	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000435345	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3CDS	ENST00000488965	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000488965	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-3UTR	ENST00000488965	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
intron-intron	ENST00000488965	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126599	+
Frame-shift	ENST00000371514	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371514	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371514	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371514	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3CDS	ENST00000528311	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3UTR	ENST00000528311	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-3UTR	ENST00000528311	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5UTR-intron	ENST00000528311	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000371509	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371509	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371509	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371509	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000407246	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000407246	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000407246	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000407246	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
Frame-shift	ENST00000371513	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371513	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-3UTR	ENST00000371513	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
5CDS-intron	ENST00000371513	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000473584	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000473584	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000473584	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000473584	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000430330	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000430330	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000430330	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000430330	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000408941	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000408941	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000408941	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000408941	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000435345	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000435345	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000435345	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000435345	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3CDS	ENST00000488965	ENST00000533760	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000488965	ENST00000397957	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-3UTR	ENST00000488965	ENST00000316851	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+
intron-intron	ENST00000488965	ENST00000401611	SCP2	chr1	53393137	+	NCAM1	chr11	113126596	+

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FusionProtFeatures for SCP2_NCAM1

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
SCP2 P22307	NCAM1 P13591

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
.

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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FusionGeneSequence for SCP2_NCAM1

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCP2_NCAM1

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page
.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene	Hgene's interactors	Tgene	Tgene's interactors
SCP2	CAV1, PITPNA, CACNA1A, ELAVL1, HSD17B4, MRPS28, TIMM44, RAB8A, ACAA1, UBL4A, RRBP1, STX7, VDAC2, RBMS1, VDAC3, TBL2, SCO2, SUGP1, ECI2, RAB31, NDUFA7, IDH3G, SRRM2, AGPS, SEPT9, MRRF, MPLKIP, PEX5, TRIP13, MYO5A, MYO5C, POLR1A, URI1, PDRG1, UXT, HMGCS1, MED20, CREB3, PDHA1	NCAM1	PRKCB, FGFR1, MDK, EGFR, PLCG1, SPTB, TUBB, PPP1CA, UCHL1, ATXN1, RHEB, ARMC1, HAX1, NUFIP1, DGUOK, DNAAF2, TMEM185A, SLC30A4, SIGLEC9, FAM134C, NTRK1, REEP5, CYP2S1, REEP1, TARDBP, ISG20, OPCML, BRF2, SDC1, NCSTN

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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RelatedDrugs for SCP2_NCAM1

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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RelatedDiseases for SCP2_NCAM1

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	SCP2	C0013421	Dystonia	1	CTD_human
Hgene	SCP2	C0152025	Polyneuropathy	1	CTD_human
Hgene	SCP2	C0270612	Leukoencephalopathies	1	CTD_human;HPO
Tgene	NCAM1	C0005586	Bipolar Disorder	5	PSYGENET
Tgene	NCAM1	C0001973	Alcoholic Intoxication, Chronic	4	PSYGENET
Tgene	NCAM1	C0011570	Mental Depression	4	PSYGENET
Tgene	NCAM1	C0011581	Depressive disorder	4	PSYGENET
Tgene	NCAM1	C0036341	Schizophrenia	3	PSYGENET
Tgene	NCAM1	C0525045	Mood Disorders	2	PSYGENET
Tgene	NCAM1	C0000786	Spontaneous abortion	1	CTD_human
Tgene	NCAM1	C0005587	Depression, Bipolar	1	PSYGENET
Tgene	NCAM1	C0024809	Marijuana Abuse	1	PSYGENET
Tgene	NCAM1	C0027626	Neoplasm Invasiveness	1	CTD_human
Tgene	NCAM1	C0041696	Unipolar Depression	1	PSYGENET
Tgene	NCAM1	C1269683	Major Depressive Disorder	1	PSYGENET

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Fusion gene ID: 32884

FusionGeneSummary for SCP2_NCAM1

FusionProtFeatures for SCP2_NCAM1

FusionGeneSequence for SCP2_NCAM1

FusionGenePPI for SCP2_NCAM1

RelatedDrugs for SCP2_NCAM1

RelatedDiseases for SCP2_NCAM1