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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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Fusion gene ID: 32879

FusionGeneSummary for SCNN1G_COL27A1

check button Fusion gene summary
Fusion gene informationFusion gene name: SCNN1G_COL27A1
Fusion gene ID: 32879
HgeneTgene
Gene symbol

SCNN1G

COL27A1

Gene ID

6340

85301

Gene namesodium channel epithelial 1 gamma subunitcollagen type XXVII alpha 1 chain
SynonymsBESC3|ENaCg|ENaCgamma|PHA1|SCNEGSTLS
Cytomap

16p12.2

9q32

Type of geneprotein-codingprotein-coding
Descriptionamiloride-sensitive sodium channel subunit gammaENaC gamma subunitamiloride-sensitive epithelial sodium channel gamma subunitamiloride-sensitive sodium channel gamma-subunitepithelial Na(+) channel subunit gammagamma-ENaCgamma-NaCHnonvoltage-gated collagen alpha-1(XXVII) chaincollagen, type XXVII, alpha 1
Modification date2018052220180523
UniProtAcc

P51170

Q8IZC6

Ensembl transtripts involved in fusion geneENST00000300061, ENST00000356083, 
ENST00000477421, 
Fusion gene scores* DoF score1 X 2 X 1=25 X 5 X 5=125
# samples 15
** MAII scorelog2(1/2*10)=2.32192809488736log2(5/125*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SCNN1G [Title/Abstract] AND COL27A1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCNN1G

GO:0035725

sodium ion transmembrane transport

24124190

HgeneSCNN1G

GO:0050891

multicellular organismal water homeostasis

24124190

HgeneSCNN1G

GO:0055078

sodium ion homeostasis

24124190


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-A2-A04T-01ASCNN1Gchr16

23224484

+COL27A1chr9

116924995

+
TCGALDBRCATCGA-A2-A04T-01ASCNN1Gchr16

23208748

+COL27A1chr9

116924995

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000300061ENST00000356083SCNN1Gchr16

23224484

+COL27A1chr9

116924995

+
5CDS-intronENST00000300061ENST00000477421SCNN1Gchr16

23224484

+COL27A1chr9

116924995

+
Frame-shiftENST00000300061ENST00000356083SCNN1Gchr16

23208748

+COL27A1chr9

116924995

+
5CDS-intronENST00000300061ENST00000477421SCNN1Gchr16

23208748

+COL27A1chr9

116924995

+

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FusionProtFeatures for SCNN1G_COL27A1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCNN1G

P51170

COL27A1

Q8IZC6

Plays a role during the calcification of cartilage andthe transition of cartilage to bone.{ECO:0000269|PubMed:17693149}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
>>>>>>>>>>>>>>>>>>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCNN1Gchr16:23224484chr9:116924995ENST00000300061+11131_55497650Topological domainCytoplasmic
HgeneSCNN1Gchr16:23224484chr9:116924995ENST00000300061+111356_76497650TransmembraneHelical%3B Name%3D1
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061283_1621201861Compositional biasNote=Pro-rich
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611003_1062201861DomainNote=Collagen-like 7
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611066_1125201861DomainNote=Collagen-like 8
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611126_1185201861DomainNote=Collagen-like 9
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611192_1251201861DomainNote=Collagen-like 10
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611258_1317201861DomainNote=Collagen-like 11
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611318_1378201861DomainNote=Collagen-like 12
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611382_1441201861DomainNote=Collagen-like 13
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611442_1501201861DomainNote=Collagen-like 14
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611502_1561201861DomainNote=Collagen-like 15
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611562_1621201861DomainNote=Collagen-like 16
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+0611660_1860201861DomainFibrillar collagen NC1
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061625_679201861DomainNote=Collagen-like 1
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061688_747201861DomainNote=Collagen-like 2
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+06171_236201861DomainNote=Laminin G-like
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061748_807201861DomainNote=Collagen-like 3
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061808_867201861DomainNote=Collagen-like 4
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061871_930201861DomainNote=Collagen-like 5
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061931_990201861DomainNote=Collagen-like 6
TgeneCOL27A1chr16:23224484chr9:116924995ENST00000356083+061625_1618201861RegionNote=Triple-helical region

- In-frame and not-retained protein feature among the 13 regional features.
>>>
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneSCNN1Gchr16:23224484chr9:116924995ENST00000300061+1113563_649497650Topological domainCytoplasmic
HgeneSCNN1Gchr16:23224484chr9:116924995ENST00000300061+111377_541497650Topological domainExtracellular
HgeneSCNN1Gchr16:23224484chr9:116924995ENST00000300061+1113542_562497650TransmembraneHelical%3B Name%3D2


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FusionGeneSequence for SCNN1G_COL27A1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.
>In-frame_SCNN1G_ENST00000300061_chr16_23224484_+_COL27A1_ENST00000356083_chr9_116924995_+_2338aa
MAPGEKIKAKIKKNLPVTGPQAPTIKELMRWYCLNTNTHGCRRIVVSRGRLRRLLWIGFTLTAVALILWQCALLVFSFYTVSVSIKVHFR
KLDFPAVTICNINPYKYSTVRHLLADLEQETREALKSLYGFPESRKRREAESWNSVSEGKQPRFSHRIPLLIFDQDEKGKARDFFTGRKR
KVGGSIIHKASNVMHIESKQVVGFQLCSNDTSDCATYTFSSGINAIQEWYKLHYMNIMAQVPLEKKINMSYSAEELLVTCFFDGVSCDAR
NFTLFHHPMHGNCYTFNNRENETILSTSMGGSEYGLQVILYINEEEYNPFLVSSTGAKVIIHRQDEYPFVEDVGTEIETAMVTSIGMHLT
ESFKLSEPYSQCTEDGSDVPIRNIYNAAYSLQICLHSCFQTKMVEKCGCAQYSQPLPPAANYCNYQQHPNWMYCYYQLHRAFVQEELGCQ
SVCKEACSFKEWTLTTSLAQWPSVVSEKWLLPVLTWDQGRQVNKKLNKGFLFSWILVSFACHLASTQGAPEDVDILQRLGLSWTKAGSPA
PPGVIPFQSGFIFTQRARLQAPTGTVIPAALGTELALVLSLCSHRVNHAFLFAVRSQKRKLQLGLQFLPGKTVVHLGSRRSVAFDLDMHD
GRWHHLALELRGRTVTLVTACGQRRVPVLLPFHRDPALDPGGSFLFGKMNPHAVQFEGALCQFSIYPVTQVAHNYCTHLRKQCGQADTYQ
SPLGPLFSQDSGRPFTFQSDLALLGLENLTTATPALGSLPAGRGPRGTVAPATPTKPQRTSPTNPHQHMAVGGPAQTPLLPAKLSASNAL
DPMLPASVGGSTRTPRPAAAQPSQKITATKIPKSLPTKPSAPSTSIVPIKSPHPTQKTAPSSFTKSALPTQKQVPPTSRPVPARVSRPAE
KPIQRNPGMPRPPPPSTRPLPPTTSSSKKPIPTLARTEAKITSHASKPASARTSTHKPPPFTALSSSPAPTPGSTRSTRPPATMVPPTSG
TSTPRTAPAVPTPGSAPTGSKKPIGSEASKKAGPKSSPRKPVPLRPGKAARDVPLSDLTTRPSPRQPQPSQQTTPALVLAPAQFLSSSPR
PTSSGYSIFHLAGSTPFPLLMGPPGPKGDCGLPGPPGLPGLPGIPGARGPRGPPGPYGNPGLPGPPGAKGQKGDPGLSPGKAHDGAKGDM
GLPGLSGNPGPPGRKGHKGYPGPAGHPGEQGQPGPEGSPGAKGYPGRQGLPGPVGDPGPKGSRGYIGLPGLFGLPGSDGERGLPGVPGKR
GKMGMPGFPGVFGERGPPGLDGNPGELGLPGPPGVPGLIGDLGVLGPIGYPGPKGMKGLMGSVGEPGLKGDKGEQGVPGVSGDPGFQGDK
GSQGLPGFPGARGKPGPLGKVGDKGSIGFPGPPGPEGFPGDIGPPGDNGPEGMKGKPGARGLPGPRGQLGPEGDEGPMGPPGAPGLEGQP
GRKGFPGRPGLDGVKGEPGDPGRPGPVGEQGFMGFIGLVGEPGIVGEKGDRGMMGPPGVPGPKGSMGHPGMPGGMGTPGEPGPQGPPGSR
GPPGMRGAKGRRGPRGPDGPAGEQGSRGLKGPPGPQGRPGRPGQQGVAGERGHLGSRGFPGIPGPSGPPGTKGLPGEPGPQGPQGPIGPP
GEMGPKGPPGAVGEPGLPGEAGMKGDLGPLGTPGEQGLIGQRGEPGLEGDSGPMGPDGLKGDRGDPGPDGEHGEKGQEGLMGEDGPPGPP
GVTGVRGPEGKSGKQGEKGRTGAKGAKGYQGQLGEMGVPGDPGPPGTPGPKGSRGSLGPTGAPGRMGAQGEPGLAGYDGHKGIVGPLGPP
GPKGEKGEQGEDGKAEGPPGPPGDRGPVGDRGDRGEPGDPGYPGQEGVQGLRGKPGQQGQPGHPGPRGWPGPKGSKGAEGPKGKQGKAGA
PGRRGVQGLQGLPGPRGVVGRQGLEGIAGPDGLPGRDGQAGQQGEQGDDGDPGPMGPAGKRGNPGVAGLPGAQGPPGFKGESGLPGQLGP
PGKRGTEGRTGLPGNQGEPGSKGQPGDSGEMGFPGMAGLFGPKGPPGDIGFKGIQGPRGPPGLMGKEGIVGPLGILGPSGLPGPKGDKGS
RGDWGLQGPRGPPGPRGRPGPPGPPGGPIQLQQDDLGAAFQTWMDTSGALRPESYSYPDRLVLDQGGEIFKTLHYLSNLIQSIKTPLGTK
ENPARVCRDLMDCEQKMVDGTYWVDPNLGCSSDTIEVSCNFTHGGQTCLKPITASKVEFAISRVQMNFLHLLSSEVTQHITIHCLNMTVW


* Fusion transcript sequences (only coding sequence (CDS) region).
>In-frame_SCNN1G_ENST00000300061_chr16_23224484_+_COL27A1_ENST00000356083_chr9_116924995_+_7014nt
ATGGCACCCGGAGAGAAGATCAAAGCCAAAATCAAGAAGAATCTGCCCGTGACGGGCCCTCAGGCGCCGACCATTAAAGAGCTGATGCGG
TGGTACTGCCTCAACACCAACACCCATGGCTGTCGCCGCATCGTGGTGTCCCGCGGCCGTCTGCGCCGCCTCCTCTGGATCGGGTTCACA
CTGACTGCCGTGGCCCTCATCCTCTGGCAGTGCGCCCTCCTCGTCTTCTCCTTCTATACTGTCTCAGTTTCCATCAAAGTCCACTTCCGG
AAGCTGGATTTTCCTGCAGTCACCATCTGCAACATCAACCCCTACAAGTACAGCACCGTTCGCCACCTTCTAGCTGACTTGGAACAGGAG
ACCAGAGAGGCCCTGAAGTCCCTGTATGGCTTTCCAGAGTCCCGGAAGCGCCGAGAGGCGGAGTCCTGGAACTCCGTCTCAGAGGGAAAG
CAGCCTAGATTCTCCCACCGGATTCCGCTGCTGATCTTTGATCAGGATGAGAAGGGCAAGGCCAGGGACTTCTTCACAGGGAGGAAGCGG
AAAGTCGGCGGTAGCATCATTCACAAGGCTTCAAATGTCATGCACATCGAGTCCAAGCAAGTGGTGGGATTCCAACTGTGCTCAAATGAC
ACCTCCGACTGTGCCACCTACACCTTCAGCTCGGGAATCAATGCCATTCAGGAGTGGTATAAGCTACACTACATGAACATCATGGCACAG
GTGCCTCTGGAGAAGAAAATCAACATGAGCTATTCTGCTGAGGAGCTGCTGGTGACCTGCTTCTTTGATGGAGTGTCCTGTGATGCCAGG
AATTTCACGCTTTTCCACCACCCGATGCATGGGAATTGCTATACTTTCAACAACAGAGAAAATGAGACCATTCTCAGCACCTCCATGGGG
GGCAGCGAATATGGGCTGCAAGTCATTTTGTACATAAACGAAGAGGAATACAACCCATTCCTCGTGTCCTCCACTGGAGCTAAGGTGATC
ATCCATCGGCAGGATGAGTATCCCTTCGTCGAAGATGTGGGAACAGAGATTGAGACAGCAATGGTCACCTCTATAGGAATGCACCTGACA
GAGTCCTTCAAGCTGAGTGAGCCCTACAGTCAGTGCACGGAGGACGGGAGTGACGTGCCAATCAGGAACATCTACAACGCTGCCTACTCG
CTCCAGATCTGCCTTCATTCATGCTTCCAGACAAAGATGGTGGAGAAATGTGGGTGTGCCCAGTACAGCCAGCCTCTACCTCCTGCAGCC
AACTACTGCAACTACCAGCAGCACCCCAACTGGATGTATTGTTACTACCAACTGCATCGAGCCTTTGTCCAGGAAGAGCTGGGCTGCCAG
TCTGTGTGCAAGGAAGCCTGCAGCTTTAAAGAGTGGACACTAACCACAAGCCTGGCACAATGGCCATCTGTGGTTTCGGAGAAGTGGTTG
CTGCCTGTTCTCACTTGGGACCAAGGCCGGCAAGTAAACAAAAAGCTCAACAAGGGGTTTCTCTTCTCCTGGATCTTAGTCTCGTTTGCC
TGTCACCTGGCCTCCACCCAAGGAGCTCCTGAAGATGTGGACATCCTCCAGCGGCTGGGCCTCAGCTGGACGAAGGCCGGGAGCCCTGCA
CCCCCGGGAGTCATTCCTTTCCAGTCGGGCTTCATCTTTACGCAGCGGGCCCGGCTCCAGGCTCCCACGGGCACCGTCATTCCTGCCGCC
TTGGGCACAGAGCTGGCACTGGTGCTGAGCCTCTGCTCCCACCGGGTGAACCATGCCTTCCTCTTCGCTGTCCGCAGCCAGAAACGCAAG
CTGCAGCTGGGCCTGCAGTTCCTCCCCGGCAAGACGGTCGTCCACCTCGGGTCCCGGCGCTCAGTGGCCTTCGACCTCGACATGCACGAC
GGGCGCTGGCACCACCTGGCCCTCGAGCTCCGAGGCCGCACAGTCACTCTGGTGACTGCCTGCGGGCAGCGCCGGGTGCCTGTCCTGCTG
CCTTTCCACAGGGACCCTGCACTCGACCCTGGGGGCTCCTTCCTCTTTGGGAAGATGAACCCGCATGCAGTCCAGTTTGAAGGTGCTCTC
TGCCAGTTCAGTATCTACCCTGTGACGCAGGTCGCTCACAATTACTGTACCCACCTGAGGAAGCAGTGTGGACAGGCTGACACGTACCAG
TCCCCACTGGGACCTCTCTTCTCCCAAGACTCTGGCAGACCTTTTACCTTCCAGTCCGACCTCGCCCTGCTAGGCCTGGAGAACTTGACC
ACTGCCACACCAGCCCTGGGGTCACTGCCAGCAGGCAGGGGACCCAGGGGGACTGTGGCACCCGCCACGCCCACCAAGCCCCAAAGGACT
AGCCCCACAAACCCTCACCAGCATATGGCGGTGGGAGGCCCAGCCCAAACCCCGCTGCTACCTGCCAAGCTGTCAGCCAGTAACGCACTT
GATCCCATGCTCCCAGCCTCTGTTGGCGGCTCTACCAGAACGCCTCGCCCTGCGGCCGCTCAACCATCACAGAAGATCACAGCCACCAAA
ATCCCCAAAAGCCTCCCTACCAAGCCTTCGGCCCCTTCTACTTCAATTGTGCCCATCAAAAGCCCCCATCCTACCCAGAAAACAGCTCCA
TCTTCATTTACAAAGTCAGCCCTACCCACTCAGAAGCAAGTGCCACCTACTTCCCGTCCAGTTCCTGCCAGAGTCTCCCGTCCCGCAGAG
AAGCCCATCCAGAGGAACCCGGGAATGCCCAGGCCCCCACCGCCCAGCACCCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCC
ATTCCCACACTAGCTCGGACTGAGGCCAAGATAACCAGCCATGCCAGTAAGCCGGCCTCTGCCCGCACCAGCACCCACAAACCTCCCCCA
TTTACTGCTTTATCCTCATCTCCTGCCCCTACTCCTGGTTCTACCAGGAGTACTCGGCCACCAGCCACGATGGTACCTCCAACTTCGGGC
ACCAGCACTCCCAGAACAGCACCTGCCGTCCCCACTCCTGGCTCAGCTCCCACTGGAAGCAAGAAGCCCATTGGATCGGAAGCCTCAAAG
AAAGCCGGACCCAAGAGCAGCCCCCGGAAGCCTGTCCCCCTCAGACCTGGGAAGGCAGCCAGGGATGTCCCCTTGAGCGATCTGACAACC
AGGCCTAGCCCCAGACAGCCCCAGCCCAGTCAGCAGACCACCCCGGCCCTGGTATTGGCCCCGGCGCAATTCCTGTCCTCCAGCCCCCGG
CCCACGAGCAGTGGCTATTCGATCTTCCACCTGGCAGGATCTACGCCTTTCCCTCTGCTGATGGGGCCTCCGGGACCCAAGGGAGACTGT
GGCTTGCCGGGTCCCCCTGGGCTACCTGGGCTACCTGGAATCCCTGGTGCACGTGGGCCTCGGGGTCCTCCTGGGCCTTATGGAAATCCA
GGTCTCCCCGGCCCTCCTGGAGCCAAAGGACAGAAAGGGGACCCAGGGCTCTCACCAGGAAAGGCCCACGATGGGGCAAAGGGTGACATG
GGCTTGCCTGGGCTCTCCGGGAATCCAGGACCTCCGGGACGAAAGGGACACAAGGGCTATCCTGGACCGGCAGGGCACCCCGGAGAACAG
GGGCAGCCAGGACCTGAGGGCAGCCCAGGGGCCAAAGGTTACCCTGGCAGGCAGGGGTTACCTGGACCGGTAGGAGATCCCGGCCCCAAA
GGCAGCAGGGGCTACATTGGGCTCCCAGGGCTCTTCGGCCTGCCAGGGTCTGATGGAGAACGAGGCCTGCCTGGCGTTCCTGGCAAGAGG
GGCAAGATGGGTATGCCGGGGTTTCCTGGAGTCTTTGGGGAAAGAGGCCCTCCTGGACTGGATGGAAATCCTGGAGAACTGGGCCTGCCA
GGCCCCCCTGGAGTCCCCGGCCTCATTGGTGACTTAGGAGTGTTGGGTCCGATTGGCTACCCGGGACCCAAGGGCATGAAGGGACTGATG
GGCAGCGTGGGGGAGCCCGGACTGAAAGGTGATAAGGGTGAACAAGGGGTTCCAGGTGTGTCAGGAGATCCCGGATTCCAAGGAGACAAG
GGGAGCCAGGGGTTGCCAGGGTTCCCCGGTGCACGGGGGAAGCCAGGGCCTCTGGGCAAAGTCGGAGACAAAGGATCCATTGGGTTTCCC
GGGCCCCCTGGACCCGAGGGATTCCCAGGAGACATCGGCCCCCCTGGCGACAATGGCCCAGAAGGCATGAAGGGTAAGCCTGGAGCCCGA
GGCCTGCCGGGACCCCGTGGGCAGCTGGGGCCCGAGGGAGATGAGGGACCCATGGGGCCGCCAGGGGCCCCTGGCTTGGAGGGTCAGCCT
GGCAGGAAGGGGTTTCCTGGGAGGCCCGGCCTGGATGGCGTGAAGGGGGAACCAGGGGATCCTGGTCGGCCGGGGCCTGTGGGAGAGCAG
GGATTTATGGGATTCATTGGTCTGGTCGGGGAGCCAGGAATCGTGGGAGAAAAGGGTGATCGTGGCATGATGGGACCCCCAGGCGTGCCT
GGACCCAAGGGGTCGATGGGTCATCCTGGAATGCCAGGTGGTATGGGGACCCCTGGAGAGCCTGGACCCCAGGGTCCTCCAGGATCTCGA
GGCCCACCAGGCATGAGGGGAGCAAAGGGACGTCGGGGCCCCCGAGGACCGGACGGACCAGCTGGGGAGCAAGGGTCCAGGGGCCTGAAG
GGCCCTCCAGGACCCCAGGGCAGACCGGGCCGGCCTGGACAGCAGGGTGTGGCTGGTGAGCGAGGCCACTTGGGCTCGAGAGGCTTTCCT
GGCATCCCGGGTCCCTCAGGCCCCCCAGGCACCAAGGGCCTCCCAGGAGAACCGGGCCCTCAGGGACCCCAGGGGCCAATTGGGCCTCCA
GGAGAGATGGGACCCAAGGGGCCGCCTGGTGCAGTGGGAGAACCGGGCCTTCCTGGGGAAGCCGGGATGAAGGGTGACCTTGGACCCCTG
GGCACTCCTGGGGAGCAGGGCCTCATTGGGCAACGGGGAGAGCCAGGCCTTGAGGGTGACAGTGGCCCCATGGGACCTGATGGGCTGAAG
GGGGACAGGGGAGACCCAGGGCCTGATGGAGAACATGGCGAGAAAGGCCAGGAAGGGCTGATGGGTGAGGACGGGCCCCCCGGCCCCCCT
GGCGTCACTGGTGTCCGGGGTCCTGAAGGAAAATCAGGGAAGCAAGGCGAGAAGGGCCGCACTGGAGCCAAGGGTGCCAAGGGCTATCAA
GGACAGCTGGGTGAGATGGGCGTCCCTGGAGACCCTGGACCCCCTGGCACTCCAGGCCCTAAAGGGTCCCGGGGCAGCCTGGGACCAACG
GGTGCTCCGGGACGCATGGGGGCCCAAGGAGAACCGGGACTGGCTGGTTATGATGGACACAAAGGCATTGTGGGACCCCTTGGACCTCCT
GGACCAAAAGGCGAAAAGGGGGAGCAGGGCGAGGACGGCAAGGCTGAGGGGCCCCCTGGGCCACCTGGAGATCGGGGCCCTGTGGGTGAT
CGAGGAGACCGCGGGGAACCGGGAGACCCTGGGTACCCTGGACAGGAGGGTGTGCAAGGCCTCCGTGGAAAGCCAGGCCAGCAGGGCCAA
CCCGGGCATCCGGGACCCCGGGGGTGGCCGGGACCCAAAGGATCGAAAGGCGCAGAGGGACCAAAGGGAAAGCAAGGCAAGGCAGGGGCC
CCAGGCCGGAGGGGGGTCCAGGGCCTGCAGGGGCTGCCAGGGCCCCGGGGCGTGGTGGGGAGACAGGGCCTCGAGGGCATCGCTGGACCA
GATGGGCTTCCTGGCAGGGACGGGCAAGCAGGACAGCAGGGGGAGCAGGGAGACGATGGGGACCCTGGCCCCATGGGCCCTGCTGGGAAG
AGAGGAAATCCAGGTGTGGCCGGCTTACCTGGAGCACAGGGACCCCCAGGATTCAAGGGTGAGAGTGGGTTACCCGGACAGCTGGGTCCC
CCTGGCAAGCGAGGAACAGAGGGCAGAACGGGGCTCCCTGGAAACCAGGGGGAGCCTGGGTCCAAAGGCCAGCCGGGCGACTCTGGCGAG
ATGGGCTTCCCAGGAATGGCAGGTCTCTTCGGACCCAAGGGCCCGCCTGGAGACATTGGCTTCAAAGGCATCCAGGGCCCTCGGGGGCCA
CCTGGCTTGATGGGAAAGGAAGGCATCGTCGGGCCCCTCGGAATCCTGGGACCTTCGGGACTCCCGGGTCCGAAGGGTGACAAAGGCAGC
CGTGGGGACTGGGGATTGCAAGGTCCGAGGGGTCCTCCCGGCCCCAGAGGGCGGCCCGGCCCCCCGGGTCCTCCAGGGGGTCCTATCCAA
TTGCAACAAGATGATCTTGGGGCAGCTTTCCAGACGTGGATGGACACCAGTGGAGCACTCAGGCCAGAGAGTTACAGCTATCCAGACCGG
CTGGTGCTGGACCAGGGAGGAGAGATCTTTAAAACCTTACACTACCTCAGCAACCTCATCCAGAGCATTAAGACGCCCCTGGGCACCAAA
GAGAACCCCGCCCGGGTCTGCAGGGACCTCATGGACTGTGAGCAGAAGATGGTGGATGGTACCTACTGGGTGGATCCAAACCTTGGCTGC
TCCTCTGACACCATCGAGGTCTCCTGCAACTTCACTCATGGTGGACAGACGTGTCTCAAGCCCATCACGGCCTCCAAGGTCGAGTTTGCC
ATCAGCCGGGTCCAGATGAATTTCCTGCACCTGCTAAGCTCCGAGGTGACCCAGCACATCACCATCCACTGCCTTAACATGACCGTGTGG
CAGGAGGGCACTGGGCAGACCCCAGCCAAGCAGGCCGTACGCTTCCGGGCCTGGAATGGACAGATTTTTGAAGCTGGGGGTCAGTTCCGG
CCCGAGGTGTCCATGGATGGCTGCAAGGTCCAAGATGGCCGCTGGCATCAGACACTCTTCACCTTCCGGACCCAAGACCCCCAACAGCTG


* Fusion transcript sequences (Full-length transcript).
>In-frame_SCNN1G_ENST00000300061_chr16_23224484_+_COL27A1_ENST00000356083_chr9_116924995_+_8973nt
CCACAAGAGCCCGCGGTGGCGCTGCCAGGGGATGCTAGCCCGAGAGCGAGCAGAGGAGCAGCGCACCCGCACGAGCCTTGGACCCTTTGG
AACCGAAAGCACGCCCGTCCTCAGAGTCCCGTCCTCAAAGTCCCATCCTCGCCATGGCACCCGGAGAGAAGATCAAAGCCAAAATCAAGA
AGAATCTGCCCGTGACGGGCCCTCAGGCGCCGACCATTAAAGAGCTGATGCGGTGGTACTGCCTCAACACCAACACCCATGGCTGTCGCC
GCATCGTGGTGTCCCGCGGCCGTCTGCGCCGCCTCCTCTGGATCGGGTTCACACTGACTGCCGTGGCCCTCATCCTCTGGCAGTGCGCCC
TCCTCGTCTTCTCCTTCTATACTGTCTCAGTTTCCATCAAAGTCCACTTCCGGAAGCTGGATTTTCCTGCAGTCACCATCTGCAACATCA
ACCCCTACAAGTACAGCACCGTTCGCCACCTTCTAGCTGACTTGGAACAGGAGACCAGAGAGGCCCTGAAGTCCCTGTATGGCTTTCCAG
AGTCCCGGAAGCGCCGAGAGGCGGAGTCCTGGAACTCCGTCTCAGAGGGAAAGCAGCCTAGATTCTCCCACCGGATTCCGCTGCTGATCT
TTGATCAGGATGAGAAGGGCAAGGCCAGGGACTTCTTCACAGGGAGGAAGCGGAAAGTCGGCGGTAGCATCATTCACAAGGCTTCAAATG
TCATGCACATCGAGTCCAAGCAAGTGGTGGGATTCCAACTGTGCTCAAATGACACCTCCGACTGTGCCACCTACACCTTCAGCTCGGGAA
TCAATGCCATTCAGGAGTGGTATAAGCTACACTACATGAACATCATGGCACAGGTGCCTCTGGAGAAGAAAATCAACATGAGCTATTCTG
CTGAGGAGCTGCTGGTGACCTGCTTCTTTGATGGAGTGTCCTGTGATGCCAGGAATTTCACGCTTTTCCACCACCCGATGCATGGGAATT
GCTATACTTTCAACAACAGAGAAAATGAGACCATTCTCAGCACCTCCATGGGGGGCAGCGAATATGGGCTGCAAGTCATTTTGTACATAA
ACGAAGAGGAATACAACCCATTCCTCGTGTCCTCCACTGGAGCTAAGGTGATCATCCATCGGCAGGATGAGTATCCCTTCGTCGAAGATG
TGGGAACAGAGATTGAGACAGCAATGGTCACCTCTATAGGAATGCACCTGACAGAGTCCTTCAAGCTGAGTGAGCCCTACAGTCAGTGCA
CGGAGGACGGGAGTGACGTGCCAATCAGGAACATCTACAACGCTGCCTACTCGCTCCAGATCTGCCTTCATTCATGCTTCCAGACAAAGA
TGGTGGAGAAATGTGGGTGTGCCCAGTACAGCCAGCCTCTACCTCCTGCAGCCAACTACTGCAACTACCAGCAGCACCCCAACTGGATGT
ATTGTTACTACCAACTGCATCGAGCCTTTGTCCAGGAAGAGCTGGGCTGCCAGTCTGTGTGCAAGGAAGCCTGCAGCTTTAAAGAGTGGA
CACTAACCACAAGCCTGGCACAATGGCCATCTGTGGTTTCGGAGAAGTGGTTGCTGCCTGTTCTCACTTGGGACCAAGGCCGGCAAGTAA
ACAAAAAGCTCAACAAGGGGTTTCTCTTCTCCTGGATCTTAGTCTCGTTTGCCTGTCACCTGGCCTCCACCCAAGGAGCTCCTGAAGATG
TGGACATCCTCCAGCGGCTGGGCCTCAGCTGGACGAAGGCCGGGAGCCCTGCACCCCCGGGAGTCATTCCTTTCCAGTCGGGCTTCATCT
TTACGCAGCGGGCCCGGCTCCAGGCTCCCACGGGCACCGTCATTCCTGCCGCCTTGGGCACAGAGCTGGCACTGGTGCTGAGCCTCTGCT
CCCACCGGGTGAACCATGCCTTCCTCTTCGCTGTCCGCAGCCAGAAACGCAAGCTGCAGCTGGGCCTGCAGTTCCTCCCCGGCAAGACGG
TCGTCCACCTCGGGTCCCGGCGCTCAGTGGCCTTCGACCTCGACATGCACGACGGGCGCTGGCACCACCTGGCCCTCGAGCTCCGAGGCC
GCACAGTCACTCTGGTGACTGCCTGCGGGCAGCGCCGGGTGCCTGTCCTGCTGCCTTTCCACAGGGACCCTGCACTCGACCCTGGGGGCT
CCTTCCTCTTTGGGAAGATGAACCCGCATGCAGTCCAGTTTGAAGGTGCTCTCTGCCAGTTCAGTATCTACCCTGTGACGCAGGTCGCTC
ACAATTACTGTACCCACCTGAGGAAGCAGTGTGGACAGGCTGACACGTACCAGTCCCCACTGGGACCTCTCTTCTCCCAAGACTCTGGCA
GACCTTTTACCTTCCAGTCCGACCTCGCCCTGCTAGGCCTGGAGAACTTGACCACTGCCACACCAGCCCTGGGGTCACTGCCAGCAGGCA
GGGGACCCAGGGGGACTGTGGCACCCGCCACGCCCACCAAGCCCCAAAGGACTAGCCCCACAAACCCTCACCAGCATATGGCGGTGGGAG
GCCCAGCCCAAACCCCGCTGCTACCTGCCAAGCTGTCAGCCAGTAACGCACTTGATCCCATGCTCCCAGCCTCTGTTGGCGGCTCTACCA
GAACGCCTCGCCCTGCGGCCGCTCAACCATCACAGAAGATCACAGCCACCAAAATCCCCAAAAGCCTCCCTACCAAGCCTTCGGCCCCTT
CTACTTCAATTGTGCCCATCAAAAGCCCCCATCCTACCCAGAAAACAGCTCCATCTTCATTTACAAAGTCAGCCCTACCCACTCAGAAGC
AAGTGCCACCTACTTCCCGTCCAGTTCCTGCCAGAGTCTCCCGTCCCGCAGAGAAGCCCATCCAGAGGAACCCGGGAATGCCCAGGCCCC
CACCGCCCAGCACCCGGCCCCTACCTCCTACCACCAGCTCCTCTAAAAAACCCATTCCCACACTAGCTCGGACTGAGGCCAAGATAACCA
GCCATGCCAGTAAGCCGGCCTCTGCCCGCACCAGCACCCACAAACCTCCCCCATTTACTGCTTTATCCTCATCTCCTGCCCCTACTCCTG
GTTCTACCAGGAGTACTCGGCCACCAGCCACGATGGTACCTCCAACTTCGGGCACCAGCACTCCCAGAACAGCACCTGCCGTCCCCACTC
CTGGCTCAGCTCCCACTGGAAGCAAGAAGCCCATTGGATCGGAAGCCTCAAAGAAAGCCGGACCCAAGAGCAGCCCCCGGAAGCCTGTCC
CCCTCAGACCTGGGAAGGCAGCCAGGGATGTCCCCTTGAGCGATCTGACAACCAGGCCTAGCCCCAGACAGCCCCAGCCCAGTCAGCAGA
CCACCCCGGCCCTGGTATTGGCCCCGGCGCAATTCCTGTCCTCCAGCCCCCGGCCCACGAGCAGTGGCTATTCGATCTTCCACCTGGCAG
GATCTACGCCTTTCCCTCTGCTGATGGGGCCTCCGGGACCCAAGGGAGACTGTGGCTTGCCGGGTCCCCCTGGGCTACCTGGGCTACCTG
GAATCCCTGGTGCACGTGGGCCTCGGGGTCCTCCTGGGCCTTATGGAAATCCAGGTCTCCCCGGCCCTCCTGGAGCCAAAGGACAGAAAG
GGGACCCAGGGCTCTCACCAGGAAAGGCCCACGATGGGGCAAAGGGTGACATGGGCTTGCCTGGGCTCTCCGGGAATCCAGGACCTCCGG
GACGAAAGGGACACAAGGGCTATCCTGGACCGGCAGGGCACCCCGGAGAACAGGGGCAGCCAGGACCTGAGGGCAGCCCAGGGGCCAAAG
GTTACCCTGGCAGGCAGGGGTTACCTGGACCGGTAGGAGATCCCGGCCCCAAAGGCAGCAGGGGCTACATTGGGCTCCCAGGGCTCTTCG
GCCTGCCAGGGTCTGATGGAGAACGAGGCCTGCCTGGCGTTCCTGGCAAGAGGGGCAAGATGGGTATGCCGGGGTTTCCTGGAGTCTTTG
GGGAAAGAGGCCCTCCTGGACTGGATGGAAATCCTGGAGAACTGGGCCTGCCAGGCCCCCCTGGAGTCCCCGGCCTCATTGGTGACTTAG
GAGTGTTGGGTCCGATTGGCTACCCGGGACCCAAGGGCATGAAGGGACTGATGGGCAGCGTGGGGGAGCCCGGACTGAAAGGTGATAAGG
GTGAACAAGGGGTTCCAGGTGTGTCAGGAGATCCCGGATTCCAAGGAGACAAGGGGAGCCAGGGGTTGCCAGGGTTCCCCGGTGCACGGG
GGAAGCCAGGGCCTCTGGGCAAAGTCGGAGACAAAGGATCCATTGGGTTTCCCGGGCCCCCTGGACCCGAGGGATTCCCAGGAGACATCG
GCCCCCCTGGCGACAATGGCCCAGAAGGCATGAAGGGTAAGCCTGGAGCCCGAGGCCTGCCGGGACCCCGTGGGCAGCTGGGGCCCGAGG
GAGATGAGGGACCCATGGGGCCGCCAGGGGCCCCTGGCTTGGAGGGTCAGCCTGGCAGGAAGGGGTTTCCTGGGAGGCCCGGCCTGGATG
GCGTGAAGGGGGAACCAGGGGATCCTGGTCGGCCGGGGCCTGTGGGAGAGCAGGGATTTATGGGATTCATTGGTCTGGTCGGGGAGCCAG
GAATCGTGGGAGAAAAGGGTGATCGTGGCATGATGGGACCCCCAGGCGTGCCTGGACCCAAGGGGTCGATGGGTCATCCTGGAATGCCAG
GTGGTATGGGGACCCCTGGAGAGCCTGGACCCCAGGGTCCTCCAGGATCTCGAGGCCCACCAGGCATGAGGGGAGCAAAGGGACGTCGGG
GCCCCCGAGGACCGGACGGACCAGCTGGGGAGCAAGGGTCCAGGGGCCTGAAGGGCCCTCCAGGACCCCAGGGCAGACCGGGCCGGCCTG
GACAGCAGGGTGTGGCTGGTGAGCGAGGCCACTTGGGCTCGAGAGGCTTTCCTGGCATCCCGGGTCCCTCAGGCCCCCCAGGCACCAAGG
GCCTCCCAGGAGAACCGGGCCCTCAGGGACCCCAGGGGCCAATTGGGCCTCCAGGAGAGATGGGACCCAAGGGGCCGCCTGGTGCAGTGG
GAGAACCGGGCCTTCCTGGGGAAGCCGGGATGAAGGGTGACCTTGGACCCCTGGGCACTCCTGGGGAGCAGGGCCTCATTGGGCAACGGG
GAGAGCCAGGCCTTGAGGGTGACAGTGGCCCCATGGGACCTGATGGGCTGAAGGGGGACAGGGGAGACCCAGGGCCTGATGGAGAACATG
GCGAGAAAGGCCAGGAAGGGCTGATGGGTGAGGACGGGCCCCCCGGCCCCCCTGGCGTCACTGGTGTCCGGGGTCCTGAAGGAAAATCAG
GGAAGCAAGGCGAGAAGGGCCGCACTGGAGCCAAGGGTGCCAAGGGCTATCAAGGACAGCTGGGTGAGATGGGCGTCCCTGGAGACCCTG
GACCCCCTGGCACTCCAGGCCCTAAAGGGTCCCGGGGCAGCCTGGGACCAACGGGTGCTCCGGGACGCATGGGGGCCCAAGGAGAACCGG
GACTGGCTGGTTATGATGGACACAAAGGCATTGTGGGACCCCTTGGACCTCCTGGACCAAAAGGCGAAAAGGGGGAGCAGGGCGAGGACG
GCAAGGCTGAGGGGCCCCCTGGGCCACCTGGAGATCGGGGCCCTGTGGGTGATCGAGGAGACCGCGGGGAACCGGGAGACCCTGGGTACC
CTGGACAGGAGGGTGTGCAAGGCCTCCGTGGAAAGCCAGGCCAGCAGGGCCAACCCGGGCATCCGGGACCCCGGGGGTGGCCGGGACCCA
AAGGATCGAAAGGCGCAGAGGGACCAAAGGGAAAGCAAGGCAAGGCAGGGGCCCCAGGCCGGAGGGGGGTCCAGGGCCTGCAGGGGCTGC
CAGGGCCCCGGGGCGTGGTGGGGAGACAGGGCCTCGAGGGCATCGCTGGACCAGATGGGCTTCCTGGCAGGGACGGGCAAGCAGGACAGC
AGGGGGAGCAGGGAGACGATGGGGACCCTGGCCCCATGGGCCCTGCTGGGAAGAGAGGAAATCCAGGTGTGGCCGGCTTACCTGGAGCAC
AGGGACCCCCAGGATTCAAGGGTGAGAGTGGGTTACCCGGACAGCTGGGTCCCCCTGGCAAGCGAGGAACAGAGGGCAGAACGGGGCTCC
CTGGAAACCAGGGGGAGCCTGGGTCCAAAGGCCAGCCGGGCGACTCTGGCGAGATGGGCTTCCCAGGAATGGCAGGTCTCTTCGGACCCA
AGGGCCCGCCTGGAGACATTGGCTTCAAAGGCATCCAGGGCCCTCGGGGGCCACCTGGCTTGATGGGAAAGGAAGGCATCGTCGGGCCCC
TCGGAATCCTGGGACCTTCGGGACTCCCGGGTCCGAAGGGTGACAAAGGCAGCCGTGGGGACTGGGGATTGCAAGGTCCGAGGGGTCCTC
CCGGCCCCAGAGGGCGGCCCGGCCCCCCGGGTCCTCCAGGGGGTCCTATCCAATTGCAACAAGATGATCTTGGGGCAGCTTTCCAGACGT
GGATGGACACCAGTGGAGCACTCAGGCCAGAGAGTTACAGCTATCCAGACCGGCTGGTGCTGGACCAGGGAGGAGAGATCTTTAAAACCT
TACACTACCTCAGCAACCTCATCCAGAGCATTAAGACGCCCCTGGGCACCAAAGAGAACCCCGCCCGGGTCTGCAGGGACCTCATGGACT
GTGAGCAGAAGATGGTGGATGGTACCTACTGGGTGGATCCAAACCTTGGCTGCTCCTCTGACACCATCGAGGTCTCCTGCAACTTCACTC
ATGGTGGACAGACGTGTCTCAAGCCCATCACGGCCTCCAAGGTCGAGTTTGCCATCAGCCGGGTCCAGATGAATTTCCTGCACCTGCTAA
GCTCCGAGGTGACCCAGCACATCACCATCCACTGCCTTAACATGACCGTGTGGCAGGAGGGCACTGGGCAGACCCCAGCCAAGCAGGCCG
TACGCTTCCGGGCCTGGAATGGACAGATTTTTGAAGCTGGGGGTCAGTTCCGGCCCGAGGTGTCCATGGATGGCTGCAAGGTCCAAGATG
GCCGCTGGCATCAGACACTCTTCACCTTCCGGACCCAAGACCCCCAACAGCTGCCCATCATCAGTGTGGACAACCTCCCTCCTGCCTCAT
CAGGGAAGCAGTACCGCCTGGAAGTTGGACCTGCGTGCTTCCTCTGACCTCTGACCTCGTGGCCACTCTAGGCCTCACGGAGGAGGGAAG
AGGAAGAGGCAAGGGGAGGGTACTGAGGGGCAGATGGCTCCAGGAGAGGCAGCTCCCCTGCCCAAGGGTCCTTGGGCAGACCCCAGCTGT
TGTCTGCCCAGTAGAAGTGGGTGGGGGTAGGAGGGGATAGGGTGTCCTTGGGAACAATGGATCCCAGCTTAGCCCCAAAGACCAACCAAA
GAGCCAGCCAGAGTAAGCTGGACCTGCAACCTGCCTGAGCCCCGTGGCCTCTCAGCTCTGCGGCCACCCCGTTCCCTCCCCAGCTTCCTG
CCCAAAGAGCCCCACATTCAAGCCAACTTGAGGGAAGGGGGCGTCTCGTCAGCTGGTCCCTGCTAGGGAGCTATTGATGTGCAATATTAG
AAAGGAGACATGAAAAAAGGAGAAAAGGAAAGACAGAAGTGTATATATATATTATTTAAACAAACAAAAAGAAGGTGCGTTACTATTTTT
TTTTCACCCGGGAAAGAGGTGAGAGGATGGGAAGGAGCAGCCAGGCGTGGGAAGCGGCGAGATCCTCGGGCTGGGGGTGCCCACGTTTGC
TACCTCCCACTGTGAAATCGCTGGTGCTCACAATTGTCTCTCACAGTGTATGTGATTTTTTTAAGGAAAAAAAAAAATCCCTATTTAAGA
TTCTGAAGGTGCTACCATTATTTTGCCACAGACTTTGAAGAAACTTTTGGATGTGGGGCATCATCCGCATCTTTCTCTCTCCTCCAAATG
ACAAAGTTTGGGGAATTTTTGAATTTTCCTAGCATCGCCCTTGTGCTCATCAGGTAATCTGCTAAGGAGGAAAAAAGAAAAGAAAAAAGG
AAAAAAAAAAAAAAAAAGCAAAACAAAAACAAAAACAAAAACCCTACCAGAAACCAGAAGTAGAGAGATTTACCATATAACTTATGGACT
TTGAAATGTCTGTCCTTTTAAGGCAGCAGGGAGGCCTGGGTGCGAAGCATGTTGGCTTGGCCCTTCACGGTCCTGGAGGGAGGTGAGGCT
GGCCTTGGAAGGCGTGCCCTGGAGAGGTCTTGGGTGAAAACTTGACCTTGAAGAAACCAATCACAAAAGCGGCGTTGGGTCAGGGCTAGG
CTTAGAGGTGAAGCATCAACATGGAACCATCTCAGGAAGCCGCATCGCCTCTTCCGAGGTCCTCACTTCCAGGAGCCTGTCCTTGCAAGA
TGCAATCATCGTTCCTGCTTTTTCATTGTCATTAAATTCTGTAGAAACCCATTGTCATTAGCTCCAAGTGTAAATTTGGGTCAAGGAGAC
AGAATAATAATGGGAATCTCGGAGTTCGACACCATAGTGACGTTCAGCGTCCTCTGAATTGTGCTACATCAGCGAACAAGTCGGCGCTTG
AATTGGATTTTGAGGTTATTTTAACCATGGAATTATTTTTATAGAAGGGGAAAATGTATGTGAAAGTCTCTATTTGTGTATTTCTCTCCT
AAAGTTGTGTCTCTTTGGGAATTGGATTTGATTTTTATTATTTAATACCTCACTTTGGCCCGTCCCCCCTCCCAACACTTCTGTATCCTC
GCCCTGCCGCCCCAGCCTGGACGCTCTGCGTGGAAGTGCGTGTTTGTAGCAGCTCGGGCCTCATCTCAGCGCTCGGATCCCTCCTGCTGC
CAGAATCCACTGGCCTCTGTCTCATTCTTGGGTTTTCCTGCTGTCTTCGTTTACGTCTCTGTCCACATGTCAGTGTATTAAAACCCCAAT


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FusionGenePPI for SCNN1G_COL27A1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCNN1GSTX1A, NEDD4, WWP2, NEDD4L, AP1M2, EPN1, USP2, COMMD1, SCNN1B, SERP1, USP8, SOX4, CTSD, SCNN1ACOL27A1MCPH1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCNN1G_COL27A1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
HgeneSCNN1GP51170DB00384TriamtereneAmiloride-sensitive sodium channel subunit gammasmall moleculeapproved
HgeneSCNN1GP51170DB00594AmilorideAmiloride-sensitive sodium channel subunit gammasmall moleculeapproved

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RelatedDiseases for SCNN1G_COL27A1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneSCNN1GC0010674Cystic Fibrosis1CTD_human
HgeneSCNN1GC0020538Hypertensive disease1CTD_human;HPO
HgeneSCNN1GC0020649Hypotension1CTD_human;HPO
HgeneSCNN1GC0033805Pseudohypoaldosteronism1CTD_human;HPO
TgeneCOL27A1C3554594STEEL SYNDROME1ORPHANET;UNIPROT