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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 3286

FusionGeneSummary for ATP13A3_DNAJC13

check button Fusion gene summary
Fusion gene informationFusion gene name: ATP13A3_DNAJC13
Fusion gene ID: 3286
HgeneTgene
Gene symbol

ATP13A3

DNAJC13

Gene ID

79572

23317

Gene nameATPase 13A3DnaJ heat shock protein family (Hsp40) member C13
SynonymsAFURS1PARK21|RME8
Cytomap

3q29

3q22.1

Type of geneprotein-codingprotein-coding
Descriptionprobable cation-transporting ATPase 13A3ATPase family homolog up-regulated in senescence cells 1ATPase type 13A3dnaJ homolog subfamily C member 13DnaJ (Hsp40) homolog, subfamily C, member 13DnaJ domain-containing protein RME-8required for receptor-mediated endocytosis 8
Modification date2018052320180523
UniProtAcc

Q9H7F0

O75165

Ensembl transtripts involved in fusion geneENST00000439040, ENST00000256031, 
ENST00000260818, ENST00000486798, 
Fusion gene scores* DoF score5 X 7 X 4=1402 X 2 X 2=8
# samples 82
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(2/8*10)=1.32192809488736
Context

PubMed: ATP13A3 [Title/Abstract] AND DNAJC13 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVCOADTCGA-D5-5540-01AATP13A3chr3

194206523

-DNAJC13chr3

132219638

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3CDSENST00000439040ENST00000260818ATP13A3chr3

194206523

-DNAJC13chr3

132219638

+
intron-intronENST00000439040ENST00000486798ATP13A3chr3

194206523

-DNAJC13chr3

132219638

+
intron-3CDSENST00000256031ENST00000260818ATP13A3chr3

194206523

-DNAJC13chr3

132219638

+
intron-intronENST00000256031ENST00000486798ATP13A3chr3

194206523

-DNAJC13chr3

132219638

+

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FusionProtFeatures for ATP13A3_DNAJC13


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ATP13A3

Q9H7F0

DNAJC13

O75165


check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for ATP13A3_DNAJC13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for ATP13A3_DNAJC13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
ATP13A3LGALS3, LGALS8, LGALS9, P2RY8, ISLR, YIPF3, C5AR2, GPR114, TPRA1, TMCO3, MAS1DNAJC13STUB1, CALM1, GSK3B, DNAJB11, RPS6KA6, GADD45A, CUL3, SNX1, ATP6V1B1, NPM1, LGR4, OGN, FCN1, BSCL2, BAG5, AP1G1, ATP6V1A, HSPA8, PRMT7, NTRK1, CLK1, LRIF1, NOP9, SNW1, EGFR, PTPRR, ACP1, KLHL2, LIPG, TMEM9B, SCAMP1, LGALS3BP, HSPA9, PIP4K2A, BAG4, SLC39A9, MUSK, HSPBP1, MANSC1, JPH4, OCLN, SERPINB2, TBCE, MLF1, EDRF1, C1orf168, IRF2BP1, NMT1, CYLD


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for ATP13A3_DNAJC13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for ATP13A3_DNAJC13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource