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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32768

FusionGeneSummary for SCAND2P_SEC11A

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAND2P_SEC11A
Fusion gene ID: 32768
HgeneTgene
Gene symbol

SCAND2P

SEC11A

Gene ID

54581

23478

Gene nameSCAN domain containing 2 pseudogeneSEC11 homolog A, signal peptidase complex subunit
SynonymsSCAND21810012E07Rik|SEC11L1|SPC18|SPCS4A|sid2895
Cytomap

15q25.2

15q25.2-q25.3

Type of genepseudoprotein-coding
DescriptionSCAN domain-containing 2egl nine homolog 1 pseudogenesignal peptidase complex catalytic subunit SEC11ASEC11-like protein 1SPase 18 kDa subunitendopeptidase SP18microsomal signal peptidase 18 kDa subunitsignal peptidase complex (18kD)signal peptidase complex 18
Modification date2018051920180523
UniProtAcc

P67812

Ensembl transtripts involved in fusion geneENST00000348993, ENST00000558134, 
ENST00000560266, ENST00000268220, 
ENST00000455959, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCAND2P [Title/Abstract] AND SEC11A [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGALDBRCATCGA-AN-A0AM-01ASCAND2Pchr15

85175529

+SEC11Achr15

85213300

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000348993ENST00000558134SCAND2Pchr15

85175529

+SEC11Achr15

85213300

-
3UTR-3UTRENST00000348993ENST00000560266SCAND2Pchr15

85175529

+SEC11Achr15

85213300

-
3UTR-3UTRENST00000348993ENST00000268220SCAND2Pchr15

85175529

+SEC11Achr15

85213300

-
3UTR-3UTRENST00000348993ENST00000455959SCAND2Pchr15

85175529

+SEC11Achr15

85213300

-

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FusionProtFeatures for SCAND2P_SEC11A


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCAND2P

SEC11A

P67812

Lectin that binds to various sugars: galactose > mannose= fucose > N-acetylglucosamine > N-acetylgalactosamine(PubMed:10224141). Acts as a chemoattractant, probably involved inthe regulation of cell migration (PubMed:28301481).{ECO:0000269|PubMed:10224141, ECO:0000269|PubMed:28301481}. Component of the microsomal signal peptidase complexwhich removes signal peptides from nascent proteins as they aretranslocated into the lumen of the endoplasmic reticulum.{ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCAND2P_SEC11A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCAND2P_SEC11A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCAND2PAPPSEC11ATNFRSF14, SLC35F6, CSNK2B, FBXO6, NUPR1, RNF2, GABRE, TCTN2, TCTN3, EVC2, TCTN1, TMEM17, TMEM216, TMEM67, MCM2, GPC1


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCAND2P_SEC11A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCAND2P_SEC11A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource