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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32757

FusionGeneSummary for SCAMP2_PLAUR

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAMP2_PLAUR
Fusion gene ID: 32757
HgeneTgene
Gene symbol

SCAMP2

PLAUR

Gene ID

10066

5329

Gene namesecretory carrier membrane protein 2plasminogen activator, urokinase receptor
Synonyms-CD87|U-PAR|UPAR|URKR
Cytomap

15q24.1

19q13.31

Type of geneprotein-codingprotein-coding
Descriptionsecretory carrier-associated membrane protein 2testis secretory sperm-binding protein Li 219purokinase plasminogen activator surface receptormonocyte activation antigen Mo3u-plasminogen activator receptor form 2urokinase-type plasminogen activator (uPA) receptor
Modification date2018052320180523
UniProtAcc

O15127

Q03405

Ensembl transtripts involved in fusion geneENST00000268099, ENST00000339082, 
ENST00000601723, ENST00000340093, 
ENST00000221264, 
Fusion gene scores* DoF score7 X 4 X 5=1404 X 2 X 4=32
# samples 84
** MAII scorelog2(8/140*10)=-0.807354922057604
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(4/32*10)=0.321928094887362
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: SCAMP2 [Title/Abstract] AND PLAUR [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAMP2

GO:0015031

protein transport

15840657

TgenePLAUR

GO:0043388

positive regulation of DNA binding

22984561


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVSKCMTCGA-ER-A3ET-06ASCAMP2chr15

75165540

-PLAURchr19

44160792

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shitENST00000268099ENST00000339082SCAMP2chr15

75165540

-PLAURchr19

44160792

-
Frame-shitENST00000268099ENST00000601723SCAMP2chr15

75165540

-PLAURchr19

44160792

-
Frame-shitENST00000268099ENST00000340093SCAMP2chr15

75165540

-PLAURchr19

44160792

-
Frame-shitENST00000268099ENST00000221264SCAMP2chr15

75165540

-PLAURchr19

44160792

-

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FusionProtFeatures for SCAMP2_PLAUR


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCAMP2

O15127

PLAUR

Q03405

Functions in post-Golgi recycling pathways. Acts as arecycling carrier to the cell surface.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCAMP2_PLAUR


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCAMP2_PLAUR


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCAMP2ST3GAL3, ARIH2, SNAP23, SCAMP1, ATP4A, TSPAN5, GPM6A, ASGR2, DLK1, ART3, RTN4, BSCL2, LPAR1, BCAP31, JAGN1, PHB, RPN1, ATP5L, TCTN3, TMEM17, REEP5, NCAPHPLAURITGB2, KNG1, EEF1A1, PFN2, FAP, ITGAM, PLAU, IGF2R, LRP1, JAK1, TYK2, PSAP, OXCT1, CTSA, CTTN, SELENBP1, SCAF4, VMA21, HDLBP, SDHAF2, UBQLN2, WDHD1, NOTCH2, TXNDC17, TBCA, ELAVL1, LYN, TEX101, TUBB3, GYLTL1B, LARGE, PKN1, PXDN, ZNF146, MBTPS1, DNA2, TAZ, LAMB2, POGLUT1, POMGNT2, ARSA, GALNS, EXT1, CHSY1, CHSY3, DDX11, DDX11L8, TUBA1A, LOXL2, ADCK1, MAN2A1, SPCS2, EOGT, NAGLU, DNAJB9, NDST2, NDST1, SGSH, ARSK, FUT11, DARS2, CNTNAP3B, MAN1A1, MGAT4B, PI4K2B, PCYOX1, FASTKD3, PCSK5, CDYL, MGAT5, LEPREL2, RPUSD3, GCLM, GALNT18, ARSB, HUS1, MELK, EMILIN3, TATDN2, CERCAM, DHFRL1, TRMT11, KIAA0391, HOXD13, DHRS4, MANEA, CCRN4L, PLTP, NR2F2, ST3GAL4, UBE3A, PPOX, MAN2A2, NEK4, EGFL7, PCYOX1L, XRCC3, MCM9, TOP2B, GLB1, TUBA4A, BMP8B, TXNDC16


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCAMP2_PLAUR


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status
TgenePLAURQ03405DB00009AlteplaseUrokinase plasminogen activator surface receptorbiotechapproved
TgenePLAURQ03405DB00029AnistreplaseUrokinase plasminogen activator surface receptorbiotechapproved
TgenePLAURQ03405DB00031TenecteplaseUrokinase plasminogen activator surface receptorbiotechapproved
TgenePLAURQ03405DB00015ReteplaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational
TgenePLAURQ03405DB00013UrokinaseUrokinase plasminogen activator surface receptorbiotechapproved|investigational|withdrawn

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RelatedDiseases for SCAMP2_PLAUR


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgenePLAURC0004352Autistic Disorder2CTD_human
TgenePLAURC0021368Inflammation1CTD_human
TgenePLAURC0027626Neoplasm Invasiveness1CTD_human
TgenePLAURC0027627Neoplasm Metastasis1CTD_human
TgenePLAURC0033578Prostatic Neoplasms1CTD_human
TgenePLAURC3495559Juvenile arthritis1CTD_human