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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32751

FusionGeneSummary for SCAI_TOX3

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAI_TOX3
Fusion gene ID: 32751
HgeneTgene
Gene symbol

SCAI

TOX3

Gene ID

286205

27324

Gene namesuppressor of cancer cell invasionTOX high mobility group box family member 3
SynonymsC9orf126|NET40CAGF9|TNRC9
Cytomap

9q33.3

16q12.1

Type of geneprotein-codingprotein-coding
Descriptionprotein SCAIsuppressor of cancer cell invasion proteinTOX high mobility group box family member 3CAG trinucleotide repeat-containing gene F9 proteintrinucleotide repeat-containing gene 9 protein
Modification date2018052320180522
UniProtAcc

Q8N9R8

O15405

Ensembl transtripts involved in fusion geneENST00000336505, ENST00000373549, 
ENST00000487795, 
ENST00000407228, 
ENST00000219746, 
Fusion gene scores* DoF score2 X 1 X 1=22 X 2 X 2=8
# samples 22
** MAII scorelog2(2/2*10)=3.32192809488736log2(2/8*10)=1.32192809488736
Context

PubMed: SCAI [Title/Abstract] AND TOX3 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTOX3

GO:0042981

regulation of apoptotic process

21172805

TgeneTOX3

GO:0043524

negative regulation of neuron apoptotic process

21172805

TgeneTOX3

GO:0045893

positive regulation of transcription, DNA-templated

21172805


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
TCGARVBRCATCGA-E9-A3HO-01ASCAIchr9

127904912

-TOX3chr16

52484458

-
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
Frame-shiftENST00000336505ENST00000407228SCAIchr9

127904912

-TOX3chr16

52484458

-
Frame-shiftENST00000336505ENST00000219746SCAIchr9

127904912

-TOX3chr16

52484458

-
Frame-shiftENST00000373549ENST00000407228SCAIchr9

127904912

-TOX3chr16

52484458

-
Frame-shiftENST00000373549ENST00000219746SCAIchr9

127904912

-TOX3chr16

52484458

-
intron-3CDSENST00000487795ENST00000407228SCAIchr9

127904912

-TOX3chr16

52484458

-
intron-3CDSENST00000487795ENST00000219746SCAIchr9

127904912

-TOX3chr16

52484458

-

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FusionProtFeatures for SCAI_TOX3


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCAI

Q8N9R8

TOX3

O15405

Tumor suppressor which functions to suppress MKL1-induced SRF transcriptional activity. May function in the RHOA-DIAPH1 signal transduction pathway and regulate cell migrationthrough transcriptional regulation of ITGB1.{ECO:0000269|PubMed:19350017}. Transcriptional coactivator of the p300/CBP-mediatedtranscription complex. Activates transactivation through cAMPresponse element (CRE) sites. Protects against cell death byinducing antiapoptotic and repressing pro-apoptotic transcripts.Stimulates transcription from the estrogen-responsive or BCL-2promoters. Required for depolarization-induced transcriptionactivation of the C-FOS promoter in neurons. Associates withchromatin to the estrogen-responsive C3 promoter region.{ECO:0000269|PubMed:21172805}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCAI_TOX3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCAI_TOX3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors
SCAIRANBP17, CBX5, HNRNPA1, CDCA5, NFATC1, NFATC2, APBA3, TNFRSF1A, CACNG5TOX3ODF2, TMEM67


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCAI_TOX3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCAI_TOX3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneTOX3C0242788Breast Neoplasms, Male1CTD_human
TgeneTOX3C1458155Mammary Neoplasms1CTD_human