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Center for Computational Systems Medicine
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FusionGeneSummary

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FusionProtFeature

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FusionGeneSequence

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FusionGenePPI

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RelatedDrugs

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RelatedDiseases

Fusion gene ID: 32736

FusionGeneSummary for SCAF11_ZMIZ1

check button Fusion gene summary
Fusion gene informationFusion gene name: SCAF11_ZMIZ1
Fusion gene ID: 32736
HgeneTgene
Gene symbol

SCAF11

ZMIZ1

Gene ID

9169

57178

Gene nameSR-related CTD associated factor 11zinc finger MIZ-type containing 1
SynonymsCASP11|SFRS2IP|SIP1|SRRP129|SRSF2IPMIZ|RAI17|TRAFIP10|ZIMP10
Cytomap

12q12

10q22.3

Type of geneprotein-codingprotein-coding
Descriptionprotein SCAF11CTD-associated SR protein 11SC35-interacting protein 1SFRS2-interacting proteinSR-related and CTD-associated factor 11SRSF2-interacting proteinrenal carcinoma antigen NY-REN-40serine/arginine-rich splicing factor 2-interacting proteinzinc finger MIZ domain-containing protein 1retinoic acid induced 17zinc finger-containing, Miz1, PIAS-like protein on chromosome 10
Modification date2018051920180519
UniProtAcc

Q99590

Q9ULJ6

Ensembl transtripts involved in fusion geneENST00000550629, ENST00000465950, 
ENST00000369367, ENST00000549162, 
ENST00000419565, ENST00000395454, 
ENST00000395453, 
ENST00000334512, 
ENST00000478357, ENST00000446377, 
Fusion gene scores* DoF score4 X 4 X 1=165 X 6 X 2=60
# samples 46
** MAII scorelog2(4/16*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
log2(6/60*10)=0
Context

PubMed: SCAF11 [Title/Abstract] AND ZMIZ1 [Title/Abstract] AND fusion [Title/Abstract]

Functional or gene categories assigned by FusionGDB annotation
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneSCAF11

GO:0000245

spliceosomal complex assembly

9447963

HgeneSCAF11

GO:0000375

RNA splicing, via transesterification reactions

9447963

HgeneSCAF11

GO:0008380

RNA splicing

9447963

TgeneZMIZ1

GO:0045944

positive regulation of transcription by RNA polymerase II

26522984


check button Fusion gene information from three resources
(ChiTars (NAR, 2018), tumorfusions (NAR, 2018), Gao et al. (Cell, 2018))
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
Data typeSourceCancer typeSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS3.1BE840759SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
* LD: Li Ding group's fusion gene list
  RV: Roel Verhaak group's fusion gene list
  ChiTaRs fusion database

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
intron-3UTRENST00000550629ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000550629ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000550629ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000465950ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000465950ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000465950ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000369367ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000369367ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000369367ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000549162ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000549162ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000549162ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000419565ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000419565ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000419565ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000395454ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000395454ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000395454ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-3UTRENST00000395453ENST00000334512SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000395453ENST00000478357SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+
intron-intronENST00000395453ENST00000446377SCAF11chr12

46347699

+ZMIZ1chr10

81075850

+

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FusionProtFeatures for SCAF11_ZMIZ1


check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
SCAF11

Q99590

ZMIZ1

Q9ULJ6

Plays a role in pre-mRNA alternative splicing byregulating spliceosome assembly. {ECO:0000269|PubMed:9447963}. Acts as transcriptional coactivator. Increases ligand-dependent transcriptional activity of AR and promotes ARsumoylation. The stimulation of AR activity is dependent uponsumoylation (PubMed:14609956, PubMed:26522984). Involved intranscriptional activation of a subset of NOTCH1 target genesincluding MYC. Involved in thymocyte and T cell development (Bysimilarity). {ECO:0000250|UniProtKB:Q6P1E1,ECO:0000269|PubMed:14609956, ECO:0000269|PubMed:26522984}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

.

* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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FusionGeneSequence for SCAF11_ZMIZ1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences.
(nt: nucleotides, aa: amino acids)

* Fusion amino acid sequences.

* Fusion transcript sequences (only coding sequence (CDS) region).

* Fusion transcript sequences (Full-length transcript).

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FusionGenePPI for SCAF11_ZMIZ1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page

.

check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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RelatedDrugs for SCAF11_ZMIZ1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.0 2018-04-02)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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RelatedDiseases for SCAF11_ZMIZ1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneZMIZ1C0007570Celiac Disease1CTD_human
TgeneZMIZ1C0009404Colorectal Neoplasms1CTD_human